DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and Scel

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_075024.2	Gene:	Scel / 64929	MGIID:	1891228	Length:	652	Species:	Mus musculus

Alignment Length:	593	Identity:	116/593 - (19%)
Similarity:	198/593 - (33%)	Gaps:	158/593 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1003 HYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAA 1067
            |..:.|.....:..|..|||||.|.            |.:|:..||.:|      .....:|||.
Mouse   146 HNASPSTAASRRDPALHPPLPPKPC------------SPIASPKPLGRT------NRQIHAATAG 192

  Fly  1068 AAATQSLSEATATANAKMQSIEDKIREQGEMLRVER-----ELLHFSQEELKRQRENLVLRENIA 1127
            |...   :|..|..|.:.:.::|.||....:.:.::     .|:..::...:.|..:.:.|.|:.
Mouse   193 ACGE---TERHAERNIRTEDLDDIIRVAAALQKTDKGEELDNLIRMNKSLNRNQGLDGLFRANLK 254

  Fly  1128 RRELQHGAKMLMS---NNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHPQQIYANVPQQ- 1188
            .::|...|:.|.|   .|.::.:|     |.||   .||...:....:..|....|...:|.:.
Mouse   255 AQQLDKRAQSLESLIYMNTQTDRD-----GKGN---QAFGSLKKINQRADPDRRSQDLRSVIRTH 311

  Fly  1189 -------QQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEP-DY 1245
                   :::..|....:::.|..|:|.......|.:.:.|       ...:.|..|..|:. ..
Mouse   312 ATAERIGRRKQDLDGLIKVNPDTNKNMKRGKSLDNLIKVTP-------EVNRSNKGGPSLDNFTK 369

  Fly  1246 AVSTRQRQPPAPYG-GSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALS 1309
            .|..|.|....... .||:|:                 .|:|......|...|.|.|..|   :.
Mouse   370 GVPARSRANQRDQDLDSLIKV-----------------TPSANRSSQHSLDELINTSPQT---IK 414

  Fly  1310 ATPKPKYADGWVQV--------QQRKSYDSQQTSDAAWLAAQQQKR-----KSMPDYGGALYNNN 1361
            .|.:.:..|.:::|        |:....||....:......:|.:.     |..|   .||.|.|
Mouse   415 TTARHQDLDKFIKVNPDVLTNNQRNHDVDSTIRGNPTGTRCEQSEELDNLIKVKP---SALRNTN 476

  Fly  1362 ------------------------------HWLLQEAEQRRI---EQLNRRSIPASKSMGKPLPD 1393
                                          :.|.:|:.:..:   |..|..|..:....|.| .|
Mouse   477 GGQDLESLTEVNSHVAEKNGRIDGQANGLTNSLFKESTRASVYSYEARNSLSSNSGNKNGGP-KD 540

  Fly  1394 SIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSV 1458
            :::.|.|....||...|..:.:.:|.|.|    .:|....:                      ||
Mouse   541 TVVYTRTYVENSKSPKDGYQENISGKYIQ----TVYSTSDR----------------------SV 579

  Fly  1459 SGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHK 1523
            ..:..|::|...||.        ...||::.|.:..|..||||.:|...|.:...|..:.:....
Mouse   580 IERDMCTYCRKPLGV--------ETKMILDELQICCHSTCFKCEICKRPLENLQAGDSIWIYRQT 636

  Fly  1524 LHCQNCYS 1531
            :||:.|||
Mouse   637 IHCEPCYS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
Scel	NP_075024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..180		12/45 (27%)
		15 X approximate tandem repeats	207..496		56/326 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..385		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..455		3/18 (17%)
		LIM	584..642	CDD:214528	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900