DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and lpp

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_957492.1	Gene:	lpp / 573024	ZFINID:	ZDB-GENE-040426-918	Length:	556	Species:	Danio rerio

Alignment Length:	811	Identity:	143/811 - (17%)
Similarity:	207/811 - (25%)	Gaps:	386/811 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 NENNQSTNQTSNSRNQKESSTAATSAANP------VPPTTPGEQAEPYYQVPKAT-EPYYDAPKH 811
            |:.:|..:.::.........|.:.|.:..      .|...|..:..||.|...|| |..|..|
Zfish     6 NDGDQQGHVSARMETSLPMGTTSISISQQQAPKKFAPVVAPKPKFNPYKQPGDATHEGDYPPP-- 68

  Fly   812 LRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLG 876
              |.||.:                  |.||..|....|||       |:||          .|||
Zfish    69 --PPPVVD------------------PSGLPSPSSFPPPP-------PMDE----------TSLG 96

  Fly   877 HNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDL 941
            .                    .::| ||                  |.|..:|||.     |.::
Zfish    97 F--------------------QIKG-PE------------------KTLEERRSSL-----DAEI 117

  Fly   942 DDMETYLELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTN 1006
            |.:.:.|          |.|                                     :||..|..
Zfish   118 DSLTSIL----------ADL-------------------------------------ESSSPYKP 135

  Fly  1007 SSEENDTQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAA-- 1069
            .:::|...          |.:|.....|......::..|.||..|.|........::.|..|:
Zfish   136 RTQQNSAS----------PAATGSTAPVTGYRRMVIPTQPPLTATKKSTPKPQAPQNVTPPASSS 190

  Fly  1070 -------ATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQRENLVLRENIA 1127
                   |.|.:..:..||:
Zfish   191 PRPQYQPAPQPVPASYTTAS--------------------------------------------- 210

  Fly  1128 RRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQM 1192
                                             :..||..:.||:...|.|||.....|.|.|.|
Zfish   211 ---------------------------------TPSQPTFNVQVRAAQPAPQQQPVRGPGQVQYM 242

  Fly  1193 VLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQP--- 1254
                                            |.:| ||           |::|..  ..||
Zfish   243 --------------------------------PAQP-RA-----------PEFAYG--PPQPGFC 261

  Fly  1255 PAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADG 1319
            |||.||...:..|.     .||.|........|::|                     |.|..:.|
Zfish   262 PAPSGGYQDQHYGG-----APGYGGQNTWRAEPSHH---------------------PAPTPSQG 300

  Fly  1320 WVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSI--- 1381
            :.....:|:|.:...:..|..|.    ..|.|..|             ..:..:::|.::.:
Zfish   301 YQPAPPKKTYITDPPASLAPFAG----GSSAPHKG-------------RPEEELDRLTKKMLYDM 348

  Fly  1382 ---PASKSMGKPLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNV----- 1438
               |:.:..|:      ..:..|.|..:|.|                   .....|..:|
Zfish   349 DNPPSEEYFGR------CSSCGENVVGEGTG-------------------CTAMDQVFHVDCFIC 388

  Fly  1439 -TNGSSINGNSSQGQEKVLSVSGKKKCSHC---GDELGKLCYYVGCRGAAMIIESLL----LFYH 1495
             |.||.:.|......||      |..|..|   ..|...:||       ..|:|.:|    ..||
Zfish   389 MTCGSKLRGKPFYAVEK------KAYCEPCYINTLETCNICY-------KPIMERILRATGKAYH 440

  Fly  1496 INCFKCCVCHVQLGDGLNGTDVRVRNHKLHC 1526
            ..||.|.|||..| ||:..| |...|| :||
Zfish   441 PQCFTCVVCHRSL-DGIPFT-VDASNH-IHC 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	17/33 (52%)
lpp	NP_957492.1	DUF2413	123..>201	CDD:287302	18/134 (13%)
		LIM1_TRIP6	360..413	CDD:188736	14/77 (18%)
		LIM	420..479	CDD:295319	22/59 (37%)
		LIM3_TRIP6	480..545	CDD:188820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900