DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and ajuba

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_701366.4	Gene:	ajuba / 572549	ZFINID:	ZDB-GENE-030131-9341	Length:	688	Species:	Danio rerio

Alignment Length:	878	Identity:	156/878 - (17%)
Similarity:	239/878 - (27%)	Gaps:	364/878 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 QATRISHRRSIPSQQTSNSNENNQSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYYQVP 799
            |..::|...|:...:..|...|..:.:.|:|:.|
Zfish    10 QKLKLSDSGSVKFSKKKNDLVNTNNNSNTNNANN------------------------------- 43

  Fly   800 KATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGH 864
             ...|..:||.:....|:..:|       |....|.|.| |.:...:...||..|..|:..|
Zfish    44 -GIVPQINAPANTSQFPLSTSV-------EACGQSAGRP-GKVGSSQRIAPPNNTAVPVAED--- 96

  Fly   865 DDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELRNK- 928
                  .|..:.|:..|.:                           |::|.:..:|....|.:.
Zfish    97 ------CGPGIEHHPSTLA---------------------------PLRRRSPQQRASCYLPDTL 128

  Fly   929 --RSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSG 991
              |.:...:...|:.|....|      .|...|.|.|....||.|..::
Zfish   129 EGRGTCDQMRRGGEGDPQGAY------SPNSRAALKQRRYSLELQQLVR---------------- 171

  Fly   992 VSENHSRQSSEHYTNSSEENDTQSEATPPPLP--PPPSTAQVGEVIYQNESLLAAQTPLLQTVKG 1054
                  ||              |..|.||||.  |||..
Zfish   172 ------RQ--------------QLLAQPPPLSSVPPPYP-------------------------- 190

  Fly  1055 NSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQREN 1119
                  |.|:.|..:|                              ||...||    |::|.: .
Zfish   191 ------THSSAARLSA------------------------------VEPSFLH----EMERHK-R 214

  Fly  1120 LVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHPQQIYAN 1184
            |.|:|.:..:.|..|.:...|....||.                             ||.|
Zfish   215 LSLQEALFYKRLSSGGEPWDSGRPASLS-----------------------------HPPQ---- 246

  Fly  1185 VPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANG-HGLEPDYAVS 1248
                                |...|.:..|    ..|..|...|..:..|..:. ......:|.|
Zfish   247 --------------------RTHDSSVGGF----FFPSAPALSPCSSFSLQESVLASPRSSFASS 287

  Fly  1249 TRQRQPPAPYGGSLVKIAGAPMPPRLPGQ-------GYPIQAPTAPAYHHQSAQNLSNMSRNTLL 1306
            |      |..||.   ..|:||..|....       ||..:....||   |..|..|.....|.|
Zfish   288 T------ASGGGG---GGGSPMGSRCSSNRTSGISLGYDNRHTPGPA---QQLQLSSTQLSGTTL 340

  Fly  1307 ALSATPKPKYA-----DGWVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMPDYG------------ 1354
            . .|.|.|...     :.|....:..|.||:.:...|.........::.||:|
Zfish   341 G-QAHPAPGKTGAPPIEVWRDCLEGVSGDSRHSYPPALSTHTVTFHRAEPDWGPIDQRGSRGDGV 404

  Fly  1355 ----------GALYNN--NHWLLQEAEQR----------RIEQLNRRSIPASKSM-------GKP 1390
                      |..|..  ...||::|...          :.:.::...:|:|.|.       |||
Zfish   405 GERARHSDLLGTRYQQELTRLLLRDAALEGEALLGGLTLKEQPVSATILPSSTSTPAPTAAPGKP 469

  Fly  1391 LPDSIIQTLTERVQSKGIGDRKRFDS-----NGNYSQVNG----NNIYQQQ-----QQQKNVTNG 1441
             |:.         .:.|:..::.|.:     .|.|...|.    :::|..:     ...:.:.|.
Zfish   470 -PEE---------PAAGVDRQEYFGTCVKCGKGVYGADNACQALDSLYHTRCFTCVSCGRTLRNK 524

  Fly  1442 SSINGNSSQGQEKVLSVSG----KKKCSHCGDELGKLCYYVGCRGAAMIIESLLL----FYHINC 1498
            ...|.|.|...::....||    .:|||.||.               :|:|.:|.    .||..|
Zfish   525 DFYNVNGSVYCKEDYMFSGFQEAAEKCSVCGH---------------LILEQILQALGNSYHPGC 574

  Fly  1499 FKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCYS 1531
            |:|.||...| ||:..|...:.|  ::|.:.|:
Zfish   575 FRCTVCSKAL-DGVPFTVDYLNN--VYCVSDYN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	13/35 (37%)
ajuba	XP_701366.4	LIM1_Ajuba_like	486..539	CDD:188738	8/52 (15%)
		LIM2_Ajuba_like	551..603	CDD:188741	20/69 (29%)
		LIM3_Ajuba_like	611..672	CDD:188822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900