DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and zyx

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_005157983.1	Gene:	zyx / 564246	ZFINID:	ZDB-GENE-070928-18	Length:	608	Species:	Danio rerio

Alignment Length:	450	Identity:	92/450 - (20%)
Similarity:	142/450 - (31%)	Gaps:	155/450 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1165 PPQHHQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPL 1229
            ||....:.:||| |::: .:||                            |.|  .||.||..|
Zfish   112 PPVAEDLHLPPP-PEEL-TSVP----------------------------SAC--FPPPPPPPP- 143

  Fly  1230 RAMQLNANGHGLEPDYAVSTRQRQPPAPYG---GSLVKI-----AGAPMPPRLPGQ--------- 1277
               .:..||.|:.     |.|..:....:.   |||..:     ...|..|:||.|
Zfish   144 ---PVPENGAGIN-----SQRLFEKQTSFDKQLGSLTDMLSEMETSGPFNPKLPSQFSSAPAPKP 200

  Fly  1278 --GYPIQAPTAP-----------AYHHQS----AQNLSNMSRNTLLALSATPKP--KYADGWVQV 1323
              |.|   ||||           ...|.|    |:.|...:|...|:.::.|.|  ..|.|....
Zfish   201 APGPP---PTAPKPALSFLPPPELQDHPSPAPWAEELRARTRPANLSTASVPAPVQSVAKGPAVA 262

  Fly  1324 QQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMG 1388
            .:.....||..|:.|      .|..|....||| ...|| .::...|.....    ..||:....
Zfish   263 PKTNFPPSQLNSNLA------SKTVSPAPSGGA-RGFNH-TVKSPPQSTFPP----PPPAAPPAP 315

  Fly  1389 KPLPDSIIQTLTERVQSKGIGDRKRF----------DSNGNYSQVNGNNIYQQQQQQKNVTNGSS 1443
            .|.|.:|.:......::..||..:.|          .....:::..|||:            .|.
Zfish   316 IPPPANIPKPAFNHSETSPIGSHQSFAPPSPAAPKTSPVSTFNRPAGNNV------------PSK 368

  Fly  1444 INGNSS-------------------------QGQEK---VLSVSGKKKCSHCGDELGKLCYYVGC 1480
            ::|:.:                         |..:|   |::....:.|..||:.|.:      .
Zfish   369 VSGSGTGSGPGGAPLTMREVEELEKMTKDFIQHMDKHPPVITSPATEVCGKCGETLSR------S 427

  Fly  1481 RGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCYSSDDGIKFSC 1540
            :.|...::.|   :|.:||.|..|...| .|:...|   |:....|:.||.|...:...|
Zfish   428 QPAVRAMDKL---FHSHCFCCVSCQRPL-QGMQFYD---RDGTPQCEECYMSSLSVCSRC 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
zyx	XP_005157983.1	LIM	383..470	CDD:295319	19/99 (19%)
		LIM	477..535	CDD:295319	0/3 (0%)
		LIM3_Zyxin	537..603	CDD:188819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900