Protein Alignment smash and lmo7b

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_001038909.3
• Gene: lmo7b / 558333
• ZFINID: ZDB-GENE-060825-242
• Length: 1384
• Species: Danio rerio
• Alignment Length: 1490
• Identity: 287/1490 - (19%)
• Similarity: 498/1490 - (33%)
• Gaps: 467/1490 - (31%)

  Fly   267 GRQYISSPGYDTSSSNAQASSPDLCEYTYEG--------AIQDYKQRVQRASSNGNGNANGKLIG 323
            ||:..|.|.|         :.|.|....:||        |:::..|  .|.|...:|.:.|....
Zfish   125 GRKAQSDPFY---------TGPQLNLKAFEGLLGIALSKALEESAQ--SRLSVRDSGYSEGWFSD 178

  Fly   324 EHIAYPTRRGS-KIEDRLSGFE--------VTSPSDTQEGVE----------------------- 356
            ....|..::.| :.||.:...:        |.|....:.|.|
Zfish   179 REELYSVKQPSYRREDSVESLDSVESRTLSVASDLTLRAGSEGCCSDAEAEHFFRMAESSKSGAP 243

  Fly   357 -KQKVDVPKVDISKRKEIFEQAKAE-----VSNGG-------APAAPKLVFRDGL-TNGNSATTA 407
             ::|..||.| :.|:::.::|....     .|..|       .||:..|.:.... ::.:|.:..
Zfish   244 IREKAHVPAV-LRKKRQDYQQGSRSYAGHLTSESGHGLCHDLPPASAFLQWASSYQSDSDSDSDR 307

  Fly   408 PKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQ--------------------- 451
            |:::..:  .|::|.|.|         :.:|:..|:..:|...|
Zfish   308 PEADPEQ--DDLASRRFR---------SVTSAAPVNFAIPSKPQGPRVTAYVTPNAGKSWLTLSD 361

  Fly   452 --RLNSLQQSVAKEEQKKPPLVALIDARQLEIMRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPA 514
              |.|....|:..|..:...     |:..|     |||.:::
Zfish   362 ATRSNQSLSSIPSENGRTDS-----DSANL-----EEEFLQR----------------------- 393

  Fly   515 LIIEEPPVADTNDDSGIQEDTADELQQQQQLNAAIAALALEERQLEEAANAVNQIEAEFDELTDL 579
              :.....:|:::|.|..:...|:|..::.|        :.|.|....||:...:...:....||
Zfish   394 --VLSNGTSDSDEDRGYADPVLDDLYARRVL--------VSEHQTSINANSDKFLPKFWTPEEDL 448

  Fly   580 HPSPL----PPSPALPAVQ----QSLQQPTVAQVPAQAVNQAAAPPL--------RDMEFSINEA 628
            |...:    ...|....:|    :|:...|:..:|.::.|.::...|        .|.|.|::.:
Zfish   449 HVRKIRLGSQRRPWYKKMQGLRSKSMGDITLEPIPQESDNSSSFDSLGPLHVHQRSDEELSLDPS 513

  Fly   629 LELALQAIDREATTKPMDKAQHPQKREQKEELGGKPEEKEPICEEQHDEESNEQGETHNEGGEMP 693
               |||.:..|       :.||.::|.::.|            .:.|::.|..:....:...::.
Zfish   514 ---ALQRVQYE-------QLQHIRQRMKENE------------AKWHEDLSRWKSRRRSANSDLH 556

  Fly   694 NKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATRISHRRSIPSQQTSNSNENNQ 758
            .|.:                       :.|||..:|........|.:|...:|.:.:|.....:.
Zfish   557 KKLE-----------------------EREQIELITTAGGASGIRTAHLTGVPEESSSMPGPMSD 598

  Fly   759 STNQTSNSRNQKESSTAATSAAN---------PVPPTTPGEQ-------AEPYYQVPKATE---- 803
            :.:..|:|    ..||:|...||         .|..|:...|       :.|...|.:.|.
Zfish   599 AGSSVSSS----GWSTSALGLANGATSALTRGTVVETSDSAQKCTGVLSSHPSAVVSEQTSQSSL 659

  Fly   804 PYYDAPKHLRPVPVY----ENVEIFYS-----------GLEISQGSVGAPVGLMEPP-KEKPPPP 852
            ...||....:..|.:    ..:|.||:           |...|:|......|:...| ..||...
Zfish   660 TAVDAESDEQQGPDFSLRSSLLESFYAGGARMSATLPRGFRRSEGCSRLSTGVTPRPFGAKPSKM 724

  Fly   853 PT--------ESPIPLDEGHDDE------LDGLGN-----SLGHN--------------TDTWSS 884
            ||        :|...|..||.|.      |.|.|.     ..||:              .|..||
Zfish   725 PTLPKVYSVDDSHKSLISGHRDHSAVPSFLGGQGKVTASAGKGHSRSSTHPINPKEEETRDGRSS 789

  Fly   885 D---NTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELR----NKRSSFLGIENDGDLD 942
            .   |:|.|....|...:|..|      |.|..:...|..:.|:|    .|.:|..........|
Zfish   790 APPMNSYATKVTMTTSIIQTSP------PAISEIRDVKVGQSEMRVCLNQKPNSGRDFGFKAHWD 848

  Fly   943 DMETYLE-LTVAPPPDMAQLLQEE-------RRLEKQLY--IKAGLCDSSDTG----ESRDSGVS 993
            .:..|:: :....|.::..||..:       ||:::..|  .|:.:..:...|    :.|..|.:
Zfish   849 SVGAYVKSVQAGSPAELYGLLMGDEIVALGGRRVDEMNYEQFKSSMETAQRNGTLLMDIRRHGQN 913

  Fly   994 ENHSRQSSEHYTNSSEENDTQSEAT----PPPLPP-----PPSTAQVGEVIYQNESLLAAQTPLL 1049
            :..|.|.|..|.:....|.|.:.:|    |....|     ..|...||:.....:......:.::
Zfish   914 DWGSGQPSLPYQSHKIINLTSATSTLIGRPEHFVPINTSSNSSVETVGKTQVNGQPANGVLSKMM 978

  Fly  1050 Q-TVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEEL 1113
            . :::.|:|....:..:.:..:...:...:.|:::.....|::.|.| |..::|:|.|  .||:.
Zfish   979 NGSIQDNAAAVRNKGGSESDISDLQVPSISTTSSSWSWDHEEERRRQ-EKWQMEQERL--LQEKY 1040

  Fly  1114 KRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHP 1178
            :|.:|.|......|::|: :|.:......:::|..|.:|           .|..|:.    ||..
Zfish  1041 RRDQEKLEEEWRRAQQEV-YGEEYCGLEEQKTLDVLSNG-----------NPAPHNS----PPFY 1089

  Fly  1179 QQIYA--------NVPQQQQQMV---LHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAM 1232
            .|..|        ||...|.:..   ..|.||          .:.....|     ..|||.|
Zfish  1090 NQSSATFSVTFNENVAAAQNRQACVQTAAGHQ----------SIKAEDKC-----DSPTKTL--- 1136

  Fly  1233 QLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNL 1297
             .:...:|. ....||.|.:..                           ..|...|.|.|.|:
Zfish  1137 -CSEESYGF-AKLTVSDRTKSK---------------------------STPALEALHKQDAK-- 1170

  Fly  1298 SNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNH 1362
                                :|   ..::|...||...:.  |....:.||..|     |:.::.
Zfish  1171 --------------------EG---CSKKKGQLSQAEKER--LQILDEMRKKTP-----LHTDSS 1205

  Fly  1363 WLLQEAEQRRIEQLNRRSIPASKSMGK-PLPDSIIQTLTERVQS--KGIGDR--KRFDSNGNY-- 1420
            |:.|     |...:|:.:|....|:.: ...|::..|.:...||  .|:..|  ....|:|:|
Zfish  1206 WIRQ-----RNASINKETITVGTSIRRYESMDNLHTTNSWSRQSYTSGLSSRPHSALGSSGSYRS 1265

  Fly  1421 ---SQVNGNNIYQQQQQQKNVTNGSSINGNSS-----------QGQEKVLSVSGKKKCSHCGDEL 1471
               |...|:.|:         :.|..:|.|::           ..|::...|||::.||.|...|
Zfish  1266 GRSSLGPGSAIF---------STGVKLNSNTTTPEPTGLESRPNSQQQGRLVSGRRMCSRCEQPL 1321

  Fly  1472 GKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDG-LNGTDVRVRNHKLHCQNCY 1530
            ||        ||||:|:||.|.:||.||||..|..:||.| .:|..||||:.:|.|..||
Zfish  1322 GK--------GAAMVIDSLELCFHIGCFKCVSCRTELGRGPESGAQVRVRHRQLFCNTCY 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950
		PAT1	<1159..>1335	CDD:401645	30/186 (16%)
		LIM	<1494..1530	CDD:395333	17/36 (47%)
lmo7b	NP_001038909.3	None