back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and limch1b

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_021336807.1	Gene:	limch1b / 557200	ZFINID:	ZDB-GENE-030131-9210	Length:	1210	Species:	Danio rerio

Alignment Length:	1375	Identity:	273/1375 - (19%)
Similarity:	455/1375 - (33%)	Gaps:	451/1375 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 SSSNAQASSPDLCEYTYEGAIQDYKQRVQRASSNGNGNANGKLI-------GEHIAYPTRRGSKI 336
            ::|:|..:.|.|..:.:||.:...::..:...|......:...|       .:.::.|.......
Zfish   152 ANSSATYNGPTLDLHEFEGLLSQMRKEAEEWDSPKRSIRDSGYIDCWESERSDSLSPPRHARDDS 216

  Fly   337 EDRLSGF-----EVTSP-------------SDTQEGVEKQKV-DVPKVDISKRKEIFEQAKAEVS 382
            .|.|...     :..||             ||::....::|: ||.|.|:..|:....:.:..|.
Zfish   217 FDSLDSIGSRSHQTPSPDGLLARGYSDGRGSDSECDTPQRKIPDVRKDDMLVRRTSCSEPRTAVP 281

  Fly   383 NGGAPAAPKLVFRDGLTN-GNSATTAPKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPV 446
                       |...|.| .|..:..| ..|||...|    ||      :.||::|::.|
Zfish   282 -----------FNQYLPNKANQGSYVP-PPVRRPRAD----RD------ESRKSWSNATS----- 319

  Fly   447 PPLKQRLNSLQQSVAKEEQKKPPLVALIDARQLEIMRGEEERMRQQQQKEKHSPSQTTLCAPKPA 511
            |...:|..|..::::.|      |.|::..|.:..:  :.:::....:..:.||...:    .|.
Zfish   320 PVGGERPFSESETLSLE------LSAVVTGRDVHCV--DSQQIDPDSKYSRASPQNES----PPK 372

  Fly   512 PPALIIEEPPVADTNDDSGIQEDT---ADELQQQQQLNAAIAALALEERQLEEAANAVNQIEAEF 573
            .|  |...|.::|....|.:.:||   :.:.|.|:|.::       ::.::||.       |.:.
Zfish   373 DP--IFLNPQLSDPQIRSPLPKDTLHPSVQPQPQEQSHS-------DQEKMEEE-------EKDR 421

  Fly   574 DELTDLHPSPLPPSPALPAVQQSLQ---QPTVAQVPAQAVNQAAAPPLRDMEFSINEAL-----E 630
            |.......|  ||:| |..:|..||   .||..               .|..||.:.::     .
Zfish   422 DGWATFCQS--PPNP-LDTLQSDLQMSHNPTAG---------------NDTRFSRSSSVFDDPES 468

  Fly   631 LALQAIDREATTKPMDKAQHPQKREQKEELGGKPEEKEPICEEQH-------------------- 675
            :::..:..|....|..:.:|.....|..:|      ||   ||.|
Zfish   469 VSMIDMRSEEDLSPHSQVRHELMHNQYNKL------KE---EEDHWQDDLAKWKSRRRSVSQDLI 524

  Fly   676 -DEESNEQGE--THNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQAT 737
             .||..:..|  ...:||....|:.|..   ||.:.|.......:|:      |.....|..:|.
Zfish   525 KKEEERKMMERLLSGDGGSQRRKSIKTY---REIVEEKERREQELHD------AYRKARTPEEAA 580

  Fly   738 RISHRRSIPSQQTSNSN------------ENNQSTNQTSNSRNQKESSTAATSAANPVPPTTPGE 790
            .:.||.   :|:.:.|.            |.:.|.:.|.:|........:::.:|:|
Zfish   581 AVLHRY---AQRFTISEAVLERLKLPKLLERSVSADPTRHSSLPISQDISSSFSASP-------- 634

  Fly   791 QAEPYYQVPKATEPYYDAPKHLR----PVPVYEN-VEIFYSGLEISQGSVGAPVGLMEPPKEKPP 850
                            :..::||    |...:.: ||...:|....:|.||....:.:|.:...|
Zfish   635 ----------------NVLQYLRQQSLPAAKFTSMVEARVTGYSPEKGIVGDAECVSDPSRSHGP 683

  Fly   851 ---PPPTES---------PIPLDE----GHDDELDGLG-NSLG-HNTDTWSSDNTYETISNGTRR 897
               |.|...         .:.|||    ..:.|.|||| ...| ........|:::....:.:.:
Zfish   684 SLGPKPYRQSRAATAGMRTVKLDERVRVNGEREDDGLGIEKTGPQRNKAEEEDSSHLQFFSSSCQ 748

  Fly   898 HLQGQPEPAQPS---PPIKRMNSTKRIKKELRNKRSSFL---GIENDGDLDDMETYLELTVAPPP 956
            |.......::.|   |.:..::||:..:...:::.::.:   .:...||:.:....||:.    |
Zfish   749 HTDSDMTDSEVSVVQPTVHMLSSTRTAESPEKHRDTTEIEGRTVPQVGDVPEFPKVLEIN----P 809

  Fly   957 DMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPP 1021
            |.....||:             .|.....:|....:....|.|.||......:::..:||::.|
Zfish   810 DETVTDQEK-------------TDERGMSDSLHDVIQMEISAQVSELTAEIPQKSTNESESSRP- 860

  Fly  1022 LPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESW-TESATAAAAATQSLSEATATANAKM 1085
                                                ||: |::..|.:|...|||     :|.|:
Zfish   861 ------------------------------------ESYRTKAELAVSAQLTSLS-----SNPKL 884

  Fly  1086 Q-------SIEDKIREQ--GEMLRVERELLHFS---QEELKRQRENLVLRENIARRELQHGAKML 1138
            :       .:.:|..|.  ..:|.:.....|||   :||..||           .|..:...:||
Zfish   885 RRDFFAQSDMAEKAHENVPPSVLNLVNRGEHFSWDPEEERNRQ-----------ERWQKEQERML 938

  Fly  1139 MSNNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTD 1203
            ....||..:.|..               :..|.|......::.|    .:::|.:|
Zfish   939 QEKYRREQEKLKQ---------------EWEQAQKEVEEEERRY----HEEEQKIL--------- 975

  Fly  1204 YRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGA 1268
             .::::.|...|     |..||..|                ...||...||...|
Zfish   976 -EETVTPLTPHS-----PIAPPVLP----------------KTQSTLHSQPDREY---------- 1008

  Fly  1269 PMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSAT-PKPKYADGWV--QVQQRKSYD 1330
                   .|| |::...:.....|....:|..::....:|..| ..|..:.|.|  :.|:.:|.|
Zfish  1009 -------KQG-PVEKQPSSENCRQRENGISEAAQRKTESLQMTVSSPLQSCGSVGQRGQEDQSQD 1065

  Fly  1331 SQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPA-----SKSMGKP 1390
            .|.|         .|..:.||                        |..|.||.     .|:...|
Zfish  1066 KQPT---------LQSSQDMP------------------------LGNRQIPQQNETWKKNTTPP 1097

  Fly  1391 LPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKV 1455
            .|                |.|||.||..|..              .|.:...|.....:.....
Zfish  1098 KP----------------GGRKRSDSIENIG--------------PNPSTSPSFTDTQAPPSPN- 1131

  Fly  1456 LSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVR 1520
            .||||||.||.||..|||        |||||||:|.|::||.||||.:|..||||...|||||:|
Zfish  1132 RSVSGKKLCSSCGHPLGK--------GAAMIIETLSLYFHIQCFKCGICKGQLGDTSTGTDVRIR 1188

  Fly  1521 NHKLHCQNCY 1530
            |..|:|..||
Zfish  1189 NGLLNCHQCY 1198

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.