DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and lmo7a

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_021334325.1	Gene:	lmo7a / 553341	ZFINID:	ZDB-GENE-030219-74	Length:	1893	Species:	Danio rerio

Alignment Length:	1541	Identity:	296/1541 - (19%)
Similarity:	482/1541 - (31%)	Gaps:	569/1541 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KAEEVKKLKEVKKEEPEEWQNNLDNWKSSRRKRVEHIIDRAVETKKLELEEHDRL----RRKSKT 146
            :.||::|::...||..::||::|..|||.||.     ::..:..||.|.|:.:::    .|||||
Zfish   815 RLEELQKMRNRLKESEDKWQDDLSRWKSKRRS-----VNSDIVKKKEEREQIEQITSVGTRKSKT 874

  Fly   147 FTEMMEERAERGGPRGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSSLSGDYDNNSVMSDHAA 211
            |.||.:||..|                                  |:|:|...:  ||::.|
Zfish   875 FKEMQDERESR----------------------------------GQSNLRDSF--NSIVDD--- 900

  Fly   212 ELDKAIGAASSVAAGVTAQNVDEQLNHINRNGSNGNHGNGAAVGQTGPSNSSKSAGRQYISSPGY 276
                                                      |.:.....|.....|.|.....|
Zfish   901 ------------------------------------------VFEDPVPRSRTLPPRSYTIDTPY 923

  Fly   277 DTSSSNAQASSPDLCEYTYEGAIQDYKQRVQRASSNGNGNANGKLIGEHIAYPTRRGSKIEDRLS 341
            ..:......|.|.|.|          |:.|....::...:.:.|        |.|....|.|:::
Zfish   924 TATDKPFVPSIPSLRE----------KEPVAGTLASDQTDLSTK--------PARASPDIPDKIN 970

  Fly   342 GFEVTSPSDTQEGVEKQKVDVPKVDISKRKEIFEQAKAEVSNGGAPAAPKLVFRDGLTNGNSATT 406
            .....|.:.||     ..:|.|                      .||         .:|.:::..
Zfish   971 NSNQMSQTTTQ-----SLLDDP----------------------VPA---------FSNSSTSLI 999

  Fly   407 APKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPLV 471
            .|.|..:..|....:|   .:.:...:.|.|||.::.....|     ||:        ..||..:
Zfish  1000 KPASATKPTSSTKPNI---SEFISNTKPAESSSDAISSLYKP-----NSM--------DTKPSGL 1048

  Fly   472 ALIDARQLEI-MRGEEERMRQQQQKEKHSPSQTTLCAPKP----------APPALIIEEPPVADT 525
            ..:.|...:| .|.:..|:             |::..|:|          .|.|..::: .|..|
Zfish  1049 DQVSASLPKIYQRSDSARL-------------TSVVMPRPFGTQSNRIASLPRAFTMDD-SVKRT 1099

  Fly   526 NDDSGIQEDTADELQQQQQLNAAIAALALEERQLEEAANAVNQIEAEFDELTDLHPSPLPP---- 586
            |.:|...:.||.:.:..|.:..       |::..:...::..:.|.|..:      ||:||
Zfish  1100 NGESNSLKKTAVQNRYAQYMTD-------EDKSQQTPDHSSEEEEVERTQ------SPVPPVNRV 1151

  Fly   587 SPALPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSINE----ALELALQAIDREAT------ 641
            || ||.....|..|          |:..   ..:|..|:|:    :.:...|. |.::|
Zfish  1152 SP-LPKSTSPLNPP----------NEVG---YNEMRISLNQKPNSSRDFGFQH-DWDSTGVRVKS 1201

  Fly   642 TKPMDKAQHPQKREQKEEL---GGKPEEKEPICEEQHDEESNEQGETHNEGGEMPNKTDKQMQG- 702
            ..|...|:..|.:...|.|   |.:      :.:..:.|..|...|...:|..:   .|.:.||
Zfish  1202 VAPGSPAEFGQVQAGDEILTVNGHR------VADMSYSEWKNSMEEALQQGSLL---MDIRRQGK 1257

  Fly   703 ---GRE----PIYENVSSTISMHEVD----NEQIATMTI--TTQTQATRISHRRSIPSQQTSN-- 752
               ||:    | |:: ..||::..:|    :|...|.::  |:|.....:....::.||...|
Zfish  1258 NNWGRDLPSLP-YKS-HKTINLTSLDPLGPSEPYHTTSLDFTSQQSKDAVVKSVNVSSQPAYNHG 1320

  Fly   753 SNENNQSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPV 817
            ||..|.:..:.|.|.|.|||.:.                                  |:|:
Zfish  1321 SNGINGAFREDSESVNNKESISL----------------------------------KNLK---- 1347

  Fly   818 YENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDTW 882
             ...|.|      .|||.|..|..:.........|....|:|              |:..:|..|
Zfish  1348 -RRSEFF------EQGSAGLTVSSLVYLCGGSETPILNVPVP--------------SITASTTRW 1391

  Fly   883 SSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETY 947
            |.|...|     .:|..:.|.|             ..|:.||...|
Zfish  1392 SWDPEEE-----RKRQEKWQKE-------------QDRLLKEKYKK------------------- 1419

  Fly   948 LELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEEND 1012
                     |..:|.:|.::.:::|                           :.|::.|..|.|
Zfish  1420 ---------DQEKLDEEWKKAQQEL---------------------------NKENFKNDEELN- 1447

  Fly  1013 TQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAA-------- 1069
                                     ..||...:.|.:         ||.|...:..|
Zfish  1448 -------------------------RHSLSTIRQPTV---------SWEEQNASKLAQIEEDKKK 1478

  Fly  1070 ---ATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQ-RENLVLRENIARRE 1130
               ..|.|.|.......:|..::::.|:|.|..|:|.|.....:||.|:| .|...|.|...|||
Zfish  1479 RQEEMQRLEEERRKREEEMLRLQEERRKQEEQQRLEEEKRKKEEEERKKQIEEKQRLEEERRRRE 1543

  Fly  1131 LQHGAKML---MSNNRRSLQDLHHGLGIGNGMLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQM 1192
            .|...:.|   ....:|.||:.....          :..:..:.|.........|.||
Zfish  1544 EQQRLEELRRKREEEQRLLQEKERNR----------REEEKKRFQEQDKVDSFCYTNV------- 1591

  Fly  1193 VLHAYHQMDTDYR---KSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQP 1254
                |.::...:|   ||..:|:|.:...|       |.:........|..||.:    .|:::.
Zfish  1592 ----YPELSYSHRSISKSTPELDEVAKTDI-------KGVYGRHRGLAGWLLEEE----LRRKKN 1641

  Fly  1255 PAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADG 1319
            |                               .....|:|..| .:.|.::|.......|:.|.|
Zfish  1642 P-------------------------------QMQRKQAASEL-ELERRSILNAMKYRNPERASG 1674

  Fly  1320 WVQVQQRKSYDSQQTSDAAWLAAQ--QQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIP 1382
            .:. :..:.|..:..:.:.....|  |:.||..     :|..:|.|:.|...          |:|
Zfish  1675 GLS-EVNRDYQKEPLTQSELERQQILQEMRKKT-----SLNTDNSWIRQSTS----------SVP 1723

  Fly  1383 ASKSMGKPLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVN----------------------- 1424
            |.:.:..|:         .|.:|....|..|.....::|..|
Zfish  1724 AKEPIDLPI---------RRGESLDNLDEPRSSWRSSWSTSNSTSSIPDYSRPHSALSGSTLQPA 1779

  Fly  1425 ---GNNIYQQQQQQKNVTNGSSINGN--SSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAA 1484
               |:...|..|...::...:|...|  ..:..::..||||:|.||.|...|||        |||
Zfish  1780 GRPGSATMQASQSMSSLRQSTSTPANPPEPRAPQRNRSVSGRKICSFCDTPLGK--------GAA 1836

  Fly  1485 MIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
            ||||||.|.||:.||||..|...||....|.:||:||.:|:|..||
Zfish  1837 MIIESLGLCYHLTCFKCSDCRSDLGGSQAGAEVRIRNQQLYCNVCY 1882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571	25/69 (36%)
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	16/35 (46%)
lmo7a	XP_021334325.1	CH	17..128	CDD:237981
		DUF4757	239..>311	CDD:318215
		DUF4757	733..881	CDD:318215	25/70 (36%)
		TOP2c	<809..1096	CDD:330395	80/450 (18%)
		PDZ	1184..1245	CDD:238080	12/67 (18%)
		Neuromodulin_N	<1396..1506	CDD:331332	27/217 (12%)
		LIM	1824..1882	CDD:259829	32/65 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4167
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930