DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and FBLIM1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001019386.1	Gene:	FBLIM1 / 54751	HGNCID:	24686	Length:	374	Species:	Homo sapiens

Alignment Length:	346	Identity:	66/346 - (19%)
Similarity:	104/346 - (30%)	Gaps:	144/346 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 PKVDISKRKEIFEQAKAEVSNG---GAPAAPKLVFRDGL--------TNGNSATTAPKSEVRRLS 416
            |:.|::..:|: .||..|...|   .|| ||......||        |.|.:|.|.|.:.::..:
Human    20 PRRDVAVAEEV-RQAVCEARRGRPWEAP-APMKTPEAGLAGRPSPWTTPGRAAATVPAAPMQLFN 82

  Fly   417 GDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPLVALIDARQLEI 481
            |                         ..|.||                               .:
Human    83 G-------------------------GCPPPP-------------------------------PV 91

  Fly   482 MRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPALIIEEPPVADTNDDSGIQEDTADELQQQQQLN 546
            :.||:.           .|....|..|.|.||.|:..|
Human    92 LDGEDV-----------LPDLDLLPPPPPPPPVLLPSE--------------------------- 118

  Fly   547 AAIAALALEERQLEEAANAVNQIEAEFDELTDLHPSPLPPSPALPAVQQSLQ----QPTVAQV-- 605
                    ||......|:.:..:|       .||.||.||.|..||...|:|    :|...::
Human   119 --------EEAPAPMGASLIADLE-------QLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPP 168

  Fly   606 -PAQAVNQAAAPPLRDMEFSINEALELALQAIDREATTKPMDKAQHPQ---KREQKEELGGK--- 663
             ||:.|.:.|:..:...........|||::|:.|:         .|.|   .|..:.:|.|:
Human   169 PPAEPVEKGASTDICAFCHKTVSPRELAVEAMKRQ---------YHAQCFTCRTCRRQLAGQSFY 224

  Fly   664 PEEKEPICEEQHDEESNEQGE 684
            .::..|:||..:.:.....|:
Human   225 QKDGRPLCEPCYQDTLERCGK 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
FBLIM1	NP_001019386.1	Filamin-binding	1..70		15/51 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..119		25/180 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..176		15/40 (38%)
		LIM	183..236	CDD:259829	13/61 (21%)
		LIM2_FBLP-1	243..295	CDD:188758	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900