Protein Alignment smash and esn

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 152/791 - (19%)
• Similarity: 252/791 - (31%)
• Gaps: 291/791 - (36%)

  Fly   878 NTDTWSSDNTYETISNGT-RRH-------LQGQPEPAQPSPPIKRMNSTKRIKKEL----RNKRS 930
            ||.|..||::..|.|:|: .||       ...|.|..:..|  :.|.|.:|.::..    |.:.:
  Fly    39 NTATTISDSSTTTASSGSPTRHRSCDSLSKSSQAEAGKLFP--RNMPSIRRSRRRAVSAERERLA 101

  Fly   931 SFLGIENDGDLDDMETYLELTVAPPPDMAQL-LQEERRLEKQLYIKAGLCDSSDTGESRDSGVSE 994
            |...:|..              ..||.|.|: ..::.||       :.:...:...:|..|..|:
  Fly   102 SRERLEEQ--------------VQPPKMPQIGAGQQSRL-------STVTKLTPRKQSSKSTCSK 145

  Fly   995 NHSRQSSEHYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNES-------LLAAQTPLLQT- 1051
            :.....::....|:....|:.:||...|.|.....::     .|||       .:|..:..:|.
  Fly   146 HRGNAPAKCIIKSAVRTKTKPKATTITLAPYEIALEL-----PNESPAPTLAMAVAQSSGCVQRK 205

  Fly  1052 --------VKGNSAESWTESATAAAAATQSLSEATATANAKMQSIE----------DKIREQGEM 1098
                    ..|.|....|:.....|..|.||   |.:..|::|..:          ::.|.:..:
  Fly   206 LSSEDQFHSSGISCNGETDDDVEVAMLTGSL---TPSQIARIQGQQILRYDDLRNLNRCRNRNAV 267

  Fly  1099 LRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAF 1163
            ....::.....:.:..|::.|....:.|| .::|             |.|:...|...:|
  Fly   268 WLNPKDTEQLLEVDKSRRKANCYFNQAIA-DDIQ-------------LSDIEEQLARFDG----- 313

  Fly  1164 QPPQHHQVQMPPP--------HPQQI---------------YANVPQQQQQMVLHAYHQMDTDYR 1205
                 |..:.|||        .|.|:               ....|||||    |.:....:.|.
  Fly   314 -----HSKRPPPPAATAPKITQPSQVIEKFKPTPAPRSSGNMQQAPQQQQ----HPHPPSSSYYT 369

  Fly  1206 KSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGL-------EPDYAV----STRQRQPPAP-- 1257
            ::.|:|                    :|:.|.|.||       .|:.|:    ||.....|:.
  Fly   370 QTESEL--------------------LQIEAGGTGLTFASHSQRPESAISQVASTAHLDVPSAAS 414

  Fly  1258 --YGGSLVK--IAGAP---------------MPPRLPGQGYPIQAPTAP---------------A 1288
              .|||.|.  ..|||               .||    ...|:.:..:|               .
  Fly   415 SGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQPP----SHLPLNSVASPLRTASYKSAAAVAGHG 475

  Fly  1289 YHHQSAQNLSNMSRNTL------LALSATPKPKYADGWV----QVQQRKSYDSQQTSDAAWLAAQ 1343
            :||...|.| :..||:.      .||.     :|.  ||    :..|.:.|.||...|
  Fly   476 FHHSHHQQL-DFQRNSQSDDDSGCALE-----EYT--WVPPGLRPDQVRLYFSQLPDD------- 525

  Fly  1344 QQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQTLTERVQSKGI 1408
                 .:|      |.|:     ..|:.|::||..:..|....:      ....:|::.
  Fly   526 -----KVP------YVNS-----PGEKYRVKQLLHQLPPQDNEV------RYCHSLSDE------ 562

  Fly  1409 GDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSGKKKCSHCGDEL-- 1471
             :||..            .|:..|::::.:..|:            |..:|.::.|..|.:.|
  Fly   563 -ERKEL------------RIFSAQRKREALGRGA------------VRLLSDERPCKGCEEPLSG 602

  Fly  1472 GKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGL----NGTDVRVRNH----KLHCQN 1528
            |.:..:....||.       |.:|..||.|.||...|.|.:    :|.....|:|    |..|..
  Fly   603 GDIVVFAQRLGAQ-------LCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSA 660

  Fly  1529 CYSSDDGIKFS 1539
            |    |.|.||
  Fly   661 C----DEIIFS 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950
		PAT1	<1159..>1335	CDD:401645	51/255 (20%)
		LIM	<1494..1530	CDD:395333	13/43 (30%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	25/162 (15%)
		LIM1_Prickle	593..651	CDD:188799	17/64 (27%)
		LIM2_Prickle	656..711	CDD:188802	6/16 (38%)
		LIM3_Prickle	716..774	CDD:188804