DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and pk

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster

Alignment Length:	1511	Identity:	266/1511 - (17%)
Similarity:	467/1511 - (30%)	Gaps:	505/1511 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 GNGAAVGQTGPSN----SSKSAGRQYISSPGYDTSSSNAQASSPDLCE------YTYEGAIQDYK 303
            |.||.....||..    ::.:||:..:::.|....:...:.::...|:      :.|....:.|:
  Fly     7 GGGAGGSSGGPGGADAAAAPAAGQATVTATGNMEPAMVPRTANLLACKQWWRVCFLYGDQQKYYR 71

  Fly   304 QRVQRASSNGNGNANGK---------------LIGEHIAYPTRRGSKIEDRLSGFEVTSPSDTQE 353
            |...:|::....:||.:               ||...:       ..:||...|.::...|.|.:
  Fly    72 QLYSKAAAQRLADANQEPDNARDREYDTVDCDLIAGQL-------DAVEDADDGIDLGDHSSTPK 129

  Fly   354 G--VEKQKVDVPKVDISKR-KEIFEQAKAEVSNGGAPAAPKLVFRDGLTNGNSATTA-PKSEVRR 414
            |  ....:...|.....:| |::....:|.|.....|.             |..||| ..|||.:
  Fly   130 GGATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPK-------------NDTTTANESSEVTQ 181

  Fly   415 LSGDISSI---------RDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPL 470
            .:..::.:         .|.:..|..:.|.:|:..:.:           ::.:..|::|
  Fly   182 RNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDATE-----------NMARFYAEQE------ 229

  Fly   471 VALIDARQLEIMRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPALIIEEPPVADTNDDSG----- 530
               ..|:.|||:..|||...|:..|....|.|.   ..:|.||   :..||......|.|
  Fly   230 ---ATAQVLEIIEQEEESPEQEAPKPALPPKQK---QQRPVPP---LPPPPANRVTQDQGTQPAA 285

  Fly   531 ----IQEDTADELQQQQQLNAAIAALALEERQLEEAANA---VNQIEAEFDELTDLHPSPLPPSP 588
                :|..||.:|   |.||     |:|.:|.|..:...   .:.|...|:||    .:...|..
  Fly   286 PQVPLQPLTAGDL---QFLN-----LSLRQRSLPRSMKPFKDAHDISFTFNEL----DTSAEPEV 338

  Fly   589 ALPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSIN-------EALELALQAIDREATTKPMD 646
            |..|.||...:| :::.|...::.....|.....||.:       .||......:...::...:.
  Fly   339 ATGAAQQESNEP-ISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALY 402

  Fly   647 KAQHPQKREQKEELGGKPEEKEPICEEQHDEESNEQGETHNEGGEMPNKTDKQMQG--------- 702
            .||        ...|..|....|:  ::|.:......:.|...|..|........|
  Fly   403 AAQ--------AAAGILPTSPLPL--QRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSP 457

  Fly   703 --GREPIYENVSSTISMHEVDNEQIATMTITTQTQATRISHRRSIPSQQTSNSNEN-------NQ 758
              ...|.|.|.......|.  :.|::. .::|.:..:.:.|    |:..||:::.:       :.
  Fly   458 GCSANPKYSNAQLPPPPHH--HHQLSP-ALSTPSPPSLLHH----PAGGTSSASAHAPFLGGPHM 515

  Fly   759 STNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYY-QVPKATEPYYDAPKHLRPVPVYENVE 822
            ...:.|:|   .:.|..|......|||....:|...|: |:|....||.::|
  Fly   516 DMQRQSHS---DDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSP------------- 564

  Fly   823 IFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDEL---DGLGNSLGHNTDTWSS 884
                         |....:.:...:.||             ||:|:   ..|.:........:|:
  Fly   565 -------------GEQYRVRQLLHQLPP-------------HDNEVRYCHSLTDEERKELRLFST 603

  Fly   885 DNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIK-------------------KELRNKRS 930
            ....:.:..|..|.|..    |:|......:.||..|.                   ...|....
  Fly   604 QRKRDALGRGNVRQLMS----ARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLV 664

  Fly   931 SFLGIENDGDLDDMETYLELTVAP---PPDMAQLLQE-------------------ERRLEKQLY 973
            ..:....||.:.....:.| |:.|   ..|...|..|                   :::|..|.|
  Fly   665 DLIYFHRDGRMYCGRHHAE-TLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRY 728

  Fly   974 IK---------------AGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEE----NDTQ----- 1014
            |.               |..||.  .||:  .||.:.......:|: ::::|    |..:
  Fly   729 IMREGKPYCLHCFDAMFAEYCDY--CGEA--IGVDQGQMSHDGQHW-HATDECFSCNTCRCSLLG 788

  Fly  1015 ------------SEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAA 1067
                        |.|.....||.||.:. |..:|      ...||..|.|:.:      ..|...
  Fly   789 RAFLPRRGAIYCSIACSKGEPPTPSDSS-GTGMY------TTPTPPTQRVRPH------PQAPLP 840

  Fly  1068 AAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQRENLVLRENIARRELQ 1132
            |....|.:.::...:.:.|               ::....|:|...:.|.:.:.....:..:...
  Fly   841 ARIPSSHASSSPPMSPQQQ---------------QQHQATFNQAMYQMQSQQMEAAGGLVDQSKS 890

  Fly  1133 HGAKMLMSNNRRSLQDLHHGLGIGNGMLSAF----------------QPPQHHQVQMPPPHPQQ- 1180
            :.|.   .::...::||.||..:|.|.|:.|                .|.......:|.|...|
  Fly   891 YAAS---DSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQR 952

  Fly  1181 --IY------ANVPQQQQQMVLHAYH----QMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQ 1233
              :|      :|:.........::||    .::..:..||.:|   :..|:.||
  Fly   953 DGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPEL---AGKLVAPP----------- 1003

  Fly  1234 LNANGHGLEPDYAVSTRQRQ---------PPAPYGGSL-------VKIAGAPMPPRLPGQGYPIQ 1282
              |:...|...:|||:.|.|         ||.|..|.:       :.:|...:||.|.|
  Fly  1004 --AHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMG------ 1060

  Fly  1283 APTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQKR 1347
            :||     |.:.....|...:|..|..|.|.|      |.:....|..|..:.:.|       |:
  Fly  1061 SPT-----HSAGDRSLNTPMSTQSASHAPPHP------VSILSGASSSSPMSGEPA-------KK 1107

  Fly  1348 K-----SMPD-----------------------------YGGALYNNNHWLLQEAEQRRIEQLNR 1378
            |     .:||                             .||..:.:.|     :.:||    .|
  Fly  1108 KGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGH-----SSRRR----RR 1163

  Fly  1379 RSIPASKS--------------------MGKPL------PDSIIQ--TLTERVQSKGIGDRKRFD 1415
            |...:|.|                    ..:||      |.|::|  .|.....|:...:|:|
  Fly  1164 RKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQRERER-- 1226

  Fly  1416 SNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQ--------------GQEKV-------LSVS 1459
                       ...:::.::.:|.:..|.:.:||:              |..:|       |:..
  Fly  1227 -----------EREREESEESDVCSTCSSSSSSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYD 1280

  Fly  1460 GKKKCSHCGDELGKLC 1475
            .|:|.|..|.:..|.|
  Fly  1281 RKRKPSELGGDKDKNC 1296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	23/136 (17%)
		LIM1_Prickle	624..682	CDD:188799	6/57 (11%)
		LIM2_Prickle	687..742	CDD:188802	8/54 (15%)
		LIM3_Prickle	747..805	CDD:188804	11/62 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900