DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smash and LMO7

DIOPT Version :9

Sequence 1:NP_001246912.1 Gene:smash / 40583 FlyBaseID:FBgn0263346 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_024305122.1 Gene:LMO7 / 4008 HGNCID:6646 Length:1727 Species:Homo sapiens


Alignment Length:1804 Identity:355/1804 - (19%)
Similarity:623/1804 - (34%) Gaps:546/1804 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 GREDLMSTSATSSTNGG------DTNG-CGKKLSVTSPDPTPYVTKQRVTRPTPPAPSKNPMQFV 69
            |...|.|.|:..:..||      ||:. ...|:...:.|...|   :|::...|    |..:.|.
Human   173 GSRSLTSCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSY---RRISAVEP----KTALPFN 230

  Fly    70 QIKPCNLYQTAQEQLKKAEEVKKLKEVKKEEPEE---------------------WQNNLDNW-- 111
            :..|    ..:::.......::|.|..|.|:...                     |..|::||  
Human   231 RFLP----NKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYTEADGTFSSNQRRIWGTNVENWPT 291

  Fly   112 -----KSS--------RRKRVEHIIDRAVETKKLE-------------------LEEHDRLRRKS 144
                 |||        :.:.:.:|:...:..:||.                   .|:.:..|.|.
Human   292 VQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQFLPKCWTPEDVNWKRIKR 356

  Fly   145 KTFTEMMEERAERGGPRGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSS--LSGDYDNNSVMS 207
            :|:....:|  .:|..|..:.       :|||.:. ||......|.:.|:.  |.|:....|::.
Human   357 ETYKPWYKE--FQGFSRRNSD-------SEDEDSG-SDRSATVFSRAQKAEHRLDGNCQRPSLLL 411

  Fly   208 DHAAELDKAIGAASSVAAGVTAQNVDEQLNHINRNG---------SNGNHGNGAAVGQT-GPSNS 262
            :.|.:  :|:.:..|.||..::...||....:....         |:..|   ..:..| ||...
Human   412 ELATK--RAVKSPDSHAARRSSSASDEPSQFLLLQALQTYSDDILSSETH---TKIDPTSGPRLI 471

  Fly   263 SKSAGRQYISSPGYDTSSSNAQASSPDLCEYTYEGAIQDYKQRVQRASSNGNGNANGKLIGEHIA 327
            ::.....|  :|||........|..|||       ...|:..|     ..|..:||        .
Human   472 TRRKNLSY--APGYRRDDLEMAALDPDL-------ENDDFFVR-----KTGAFHAN--------P 514

  Fly   328 YPTRRGSKIEDRLSGFEVTSPSDTQEGVEKQKV-----------DVPKVDISKRKEIFEQAKAEV 381
            |..|   ..||    |...|..|  :.||:..:           |:.|.|:..|:  ....|.||
Human   515 YVLR---AFED----FRKFSEQD--DSVERDIILQCREGELVLPDLEKDDMIVRR--IPAQKKEV 568

  Fly   382 SNGGAPAAPKLVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPV 446
            ...|||              :.....|..|...|..:|.:  ..:..||:...:...|.|..:.|
Human   569 PLSGAP--------------DRYHPVPFPEPWTLPPEIQA--KFLCVLERTCPSKEKSNSCRILV 617

  Fly   447 PPLKQRLNSLQQSVAKEEQK------KPPL------VALIDARQLEIMRGEEERMRQQQQKEKHS 499
            |..:|:.:.:   :.::.|.      .||:      .:..|.::.|.:| |..|:|.:::     
Human   618 PSYRQKKDDM---LTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIR-EASRLRHKKR----- 673

  Fly   500 PSQTTLCAPKPAPPALIIEE--PPVADTNDDSGIQEDTADELQQQQQLN----AAIAALALEERQ 558
                           |::|.  ..:...|....:.:.:|:::|..:||.    ..|.:...|:.|
Human   674 ---------------LMVERLFQKIYGENGSKSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQDQ 723

  Fly   559 ---------LEEAANAVNQIEAEFDELTDLHPSPLPPSPALPAVQQSLQQPTVAQVPAQAVNQAA 614
                     .:...:..:.::.:.:|..::....|..|.......:.:.|...:|      ||.:
Human   724 KWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKTFKEMLQDRESQ------NQKS 782

  Fly   615 APPLRDMEFSINEALELALQAIDREATTKP-MDKAQHPQKREQKEELGGK-----PEEKEPICEE 673
            ..|.|...:|.::.||        |....| |..::...:.|:.||.|..     |:|......:
Human   783 TVPSRRRMYSFDDVLE--------EGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTFAK 839

  Fly   674 QHDEESNEQGETHNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATR 738
            :.|..:.|.        ::|:::         |:.|...:::|         :..:.:||.::||
Human   840 REDRVTTEI--------QLPSQS---------PVEEQSPASLS---------SLRSRSTQMESTR 878

  Fly   739 I------SHRR-----------------------SIPSQQTSNS----NENNQSTNQTSNS---- 766
            :      |:|:                       |:|...|.:.    |.:.:...:|.|:    
Human   879 VSASLPRSYRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVST 943

  Fly   767 --------------RNQKESSTAATSAANPVPPTTP----------------------------G 789
                          .:|||.:...........||:|                            |
Human   944 PAPSPDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESG 1008

  Fly   790 E-QAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYS------GLEISQGSVGAPVGLMEPPKE 847
            | :..|..:|.::.:.:.|....:...| .::::..::      |:.::....|:|...      
Human  1009 EGEISPQREVSRSQDQFSDMRISINQTP-GKSLDFGFTIKWDIPGIFVASVEAGSPAEF------ 1066

  Fly   848 KPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDT--W--SSDNTYET--ISNGTRRHLQ---GQP 903
                    |.:.:    |||:..:.|:.....|:  |  :.....||  :....||:.:   |:.
Human  1067 --------SQLQV----DDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKADWGKD 1119

  Fly   904 EPAQPSPPIKRMNSTKRIKKELRNKRSSFL----GIENDGDLDDMETYLELTVAPPPDMAQLLQE 964
            :|:.|....|.:|.|....|.:.:..:.::    ||.|    .:..:.|.:|.    |.::.||.
Human  1120 QPSLPFIRHKTLNLTSMATKIIGSPETKWIDATSGIYN----SEKSSNLSVTT----DFSESLQS 1176

  Fly   965 ERRLEKQLYIKAGLCDSSDTGESRDS-GVSENHSRQSSEHYTNSSEEND--------TQSEATPP 1020
            .....|::   .|:.|.|:..||:.| .:|..:.::.|:.:...|....        ..|::..|
Human  1177 SNIESKEI---NGIHDESNAFESKASESISLKNLKRRSQFFEQGSSGFSYSSWVYLCGSSDSVVP 1238

  Fly  1021 PLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKM 1085
            .||.|..:|....|..|.|             :....|.|.:             |.......|.
Human  1239 DLPVPTISAPSRWVWDQEE-------------ERKRQERWQK-------------EQDRLLQEKY 1277

  Fly  1086 QSIEDKIREQGEMLR--VERELLHFSQEELKRQREN---LVLRE-NIARREL--QHGAKMLMSNN 1142
            |..::|:||:.:..:  .|||...:..|||.....|   |..|| ::|..|.  ..|:|   |::
Human  1278 QREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSK---SSD 1339

  Fly  1143 RRSLQDLHHGLGIGNGMLSAFQPPQH--HQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYR 1205
            |.         |...|.....||.:.  |:.|...|..|.:.....:.:||:      |.:.:.:
Human  1340 RE---------GTRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQL------QEEQEQK 1389

  Fly  1206 KSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQ-RQPPAPYGGSLVKIAGAP 1269
            :..::..|           ..:|....:..|.   :|.:.:|...| |:|...|.....:.|.:.
Human  1390 RLQAEAEE-----------QKRPAEEQKRQAE---IERETSVRIYQYRRPVDSYDIPKTEEASSG 1440

  Fly  1270 MPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTL----LALSATPKPKYAD--GWVQVQQRKS 1328
            .   |||.                    .|.||:|.    .:.:.....||.|  |.:...||:|
Human  1441 F---LPGD--------------------RNKSRSTTELDDYSTNKNGNNKYLDQIGNMTSSQRRS 1482

  Fly  1329 YDSQQTSDAAWLAAQ--QQKRKSMPDYGGALYNNNHWLLQEAE------------QRRIEQLNRR 1379
            ...|..|.|.....|  |:.||..|     |:|:|.|:.|.:.            .||.|.|:..
Human  1483 KKEQVPSGAELERQQILQEMRKRTP-----LHNDNSWIRQRSASVNKEPVSLPGIMRRGESLDNL 1542

  Fly  1380 SIPASKSMGKPLPDSIIQTLTERVQSKGIGDRKR------FDSNGNYSQVNGNNIYQQQQ-QQKN 1437
            ..|.|.|..:|   ..:...|....|..:.|..|      ..||..|.:...:::..... ..|.
Human  1543 DSPRSNSWRQP---PWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKT 1604

  Fly  1438 VTNG-----------SSINGNSSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLL 1491
            .|.|           .|.:.:.|..|.:..|||||:.||:|.:.|||        |||||||||.
Human  1605 STTGVATTQSPTPRSHSPSASQSGSQLRNRSVSGKRICSYCNNILGK--------GAAMIIESLG 1661

  Fly  1492 LFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCYSSDDGIKFSC 1540
            |.||::||||..|...||...:|.:||:|||:|:|.:||     ::|.|
Human  1662 LCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCY-----LRFKC 1705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smashNP_001246912.1 DUF4757 14..152 CDD:292571 33/199 (17%)
LIM <1494..1530 CDD:278823 17/35 (49%)
LMO7XP_024305122.1 DUF4757 213..>263 CDD:318215 10/60 (17%)
DUF4757 627..774 CDD:318215 22/170 (13%)
PDZ 1042..1109 CDD:238080 12/84 (14%)
GBP_C <1255..1311 CDD:328214 16/81 (20%)
Neuromodulin_N <1256..1414 CDD:331332 40/215 (19%)
coiled coil 1298..1309 CDD:293879 4/10 (40%)
LIM 1642..1700 CDD:259829 33/65 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1704
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4167
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.930

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