Protein Alignment smash and LMO7

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_047286270.1
• Gene: LMO7 / 4008
• HGNCID: 6646
• Length: 1711
• Species: Homo sapiens
• Alignment Length: 1794
• Identity: 353/1794 - (19%)
• Similarity: 619/1794 - (34%)
• Gaps: 541/1794 - (30%)

  Fly    12 GREDLMSTSATSSTNGG------DTNG-CGKKLSVTSPDPTPYVTKQRVTRPTPPAPSKNPMQFV 69
            |...|.|.|:..:..||      ||:. ...|:...:.|...|   :|::...|    |..:.|.
Human   173 GSRSLTSCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSY---RRISAVEP----KTALPFN 230

  Fly    70 QIKPCNLYQTAQEQLKKAEEVKKLKEVKKEEPEE---------------------WQNNLDNW-- 111
            :..|    ..:::.......::|.|..|.|:...                     |..|::||
Human   231 RFLP----NKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYTEADGTFSSNQRRIWGTNVENWPT 291

  Fly   112 -----KSS--------RRKRVEHIIDRAVETKKLE-------------------LEEHDRLRRKS 144
                 |||        :.:.:.:|:...:..:||.                   .|:.:..|.|.
Human   292 VQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQFLPKCWTPEDVNWKRIKR 356

  Fly   145 KTFTEMMEERAERGGPRGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSS--LSGDYDNNSVMS 207
            :|:....:|  .:|..|..:.       :|||.:. ||......|.:.|:.  |.|:....|::.
Human   357 ETYKPWYKE--FQGFSRRNSD-------SEDEDSG-SDRSATVFSRAQKAEHRLDGNCQRPSLLL 411

  Fly   208 DHAAELDKAIGAASSVAAGVTAQNVDEQLNHINRNG---------SNGNHGNGAAVGQT-GPSNS 262
            :.|.:  :|:.:..|.||..::...||....:....         |:..|   ..:..| ||...
Human   412 ELATK--RAVKSPDSHAARRSSSASDEPSQFLLLQALQTYSDDILSSETH---TKIDPTSGPRLI 471

  Fly   263 SKSAGRQYISSPGYDTSSSNAQASSPDLCEYTYEGAIQDYKQRVQRASSNGNGNANGKLIGEHIA 327
            ::.....|  :|||........|..|||       ...|:..|     ..|..:||        .
Human   472 TRRKNLSY--APGYRRDDLEMAALDPDL-------ENDDFFVR-----KTGAFHAN--------P 514

  Fly   328 YPTRRGSKIEDRLSGFEVTSPSDTQEGVEKQKV-----------DVPKVDISKRKEIFEQAKAEV 381
            |..|   ..||    |...|..|  :.||:..:           |:.|.|:..|:  ....|.||
Human   515 YVLR---AFED----FRKFSEQD--DSVERDIILQCREGELVLPDLEKDDMIVRR--IPAQKKEV 568

  Fly   382 SNGGAPAAPKLVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPV 446
            ...|||              :.....|..|...|..:|.:  ..:..||:...:...|.|..:.|
Human   569 PLSGAP--------------DRYHPVPFPEPWTLPPEIQA--KFLCVLERTCPSKEKSNSCRILV 617

  Fly   447 PPLKQRLNSLQQSVAKEEQK------KPPL------VALIDARQLEIMRGEEERMRQQQQKEKHS 499
            |..:|:.:.:   :.::.|.      .||:      .:..|.::.|.:| |..|:|.:::
Human   618 PSYRQKKDDM---LTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIR-EASRLRHKKR----- 673

  Fly   500 PSQTTLCAPKPAPPALIIEE--PPVADTNDDSGIQEDTADELQQQQQLN----AAIAALALEERQ 558
                           |::|.  ..:...|....:.:.:|:::|..:||.    ..|.:...|:.|
Human   674 ---------------LMVERLFQKIYGENGSKSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQDQ 723

  Fly   559 ---------LEEAANAVNQIEAEFDELTDLHPSPLPPSPALPAVQQSLQQPTVAQVPAQAVNQAA 614
                     .:...:..:.::.:.:|..::....|..|.......:.:.|...:|      ||.:
Human   724 KWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKTFKEMLQDRESQ------NQKS 782

  Fly   615 APPLRDMEFSINEALELALQAIDREATTKP-MDKAQHPQKREQKEELGGK-----PEEKEPICEE 673
            ..|.|...:|.::.||        |....| |..::...:.|:.||.|..     |:|......:
Human   783 TVPSRRRMYSFDDVLE--------EGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTFAK 839

  Fly   674 QHDEESNEQGETHNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATR 738
            :.|..:.|.        ::|:::         |:.|...:::|         :..:.:||.::||
Human   840 REDRVTTEI--------QLPSQS---------PVEEQSPASLS---------SLRSRSTQMESTR 878

  Fly   739 I------SHRR-----------------------SIPSQQTSNS----NENNQSTNQTSNS---- 766
            :      |:|:                       |:|...|.:.    |.:.:...:|.|:
Human   879 VSASLPRSYRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVST 943

  Fly   767 --------------RNQKESSTAATSAANPVPPTTP----------------------------G 789
                          .:|||.:...........||:|                            |
Human   944 PAPSPDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESG 1008

  Fly   790 E-QAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYS------GLEISQGSVGAPVGLMEPPKE 847
            | :..|..:|.::.:.:.|....:...| .::::..::      |:.::....|:|...
Human  1009 EGEISPQREVSRSQDQFSDMRISINQTP-GKSLDFGFTIKWDIPGIFVASVEAGSPAEF------ 1066

  Fly   848 KPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDT--W--SSDNTYET--ISNGTRRHLQ---GQP 903
                    |.:.:    |||:..:.|:.....|:  |  :.....||  :....||:.:   |:.
Human  1067 --------SQLQV----DDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKADWGKD 1119

  Fly   904 EPAQPSPPIKRMNSTKRIKKELRNKRSSFL----GIENDGDLDDMETYLELTVAPPPDMAQLLQE 964
            :|:.|....|.:|.|....|.:.:..:.::    ||.|    .:..:.|.:|.    |.::.||.
Human  1120 QPSLPFIRHKTLNLTSMATKIIGSPETKWIDATSGIYN----SEKSSNLSVTT----DFSESLQS 1176

  Fly   965 ERRLEKQLYIKAGLCDSSDTGESRDS-GVSENHSRQSSEHYTNSSEEND--------TQSEATPP 1020
            .....|::   .|:.|.|:..||:.| .:|..:.::.|:.:...|....        ..|::..|
Human  1177 SNIESKEI---NGIHDESNAFESKASESISLKNLKRRSQFFEQGSSGFSYSSWVYLCGSSDSVVP 1238

  Fly  1021 PLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKM 1085
            .||.|..:|....|..|.|             :....|.|.:             |.......|.
Human  1239 DLPVPTISAPSRWVWDQEE-------------ERKRQERWQK-------------EQDRLLQEKY 1277

  Fly  1086 QSIEDKIREQGEMLR--VERELLHFSQEELKRQREN---LVLRE-NIARREL--QHGAKMLMSNN 1142
            |..::|:||:.:..:  .|||...:..|||.....|   |..|| ::|..|.  ..|:|   |::
Human  1278 QREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSK---SSD 1339

  Fly  1143 RRSLQDLHHGLGIGNGMLSAFQPPQH--HQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYR 1205
            |.         |...|.....||.:.  |:.|...|..|.:.....:.:||:      |.:.:.:
Human  1340 RE---------GTRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQL------QEEQEQK 1389

  Fly  1206 KSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQ-RQPPAPYGGSLVKIAGAP 1269
            :..::..|           ..:|....:..|.   :|.:.:|...| |:|...|.....:.|.:.
Human  1390 RLQAEAEE-----------QKRPAEEQKRQAE---IERETSVRIYQYRRPVDSYDIPKTEEASSG 1440

  Fly  1270 MPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTL----LALSATPKPKYAD--GWVQVQQRKS 1328
            .   |||.                    .|.||:|.    .:.:.....||.|  |.:...||:|
Human  1441 F---LPGD--------------------RNKSRSTTELDDYSTNKNGNNKYLDQIGNMTSSQRRS 1482

  Fly  1329 YDSQQTSDAAWLAAQ--QQKRKSMPDYGGALYNNNHWLLQEAE------------QRRIEQLNRR 1379
            ...|..|.|.....|  |:.||..|     |:|:|.|:.|.:.            .||.|.|:..
Human  1483 KKEQVPSGAELERQQILQEMRKRTP-----LHNDNSWIRQRSASVNKEPVSLPGIMRRGESLDNL 1542

  Fly  1380 SIPASKSMGKPLPDSIIQTLTERVQSKGIGDRKR------FDSNGNYSQVNGNNIYQQQQ-QQKN 1437
            ..|.|.|..:|   ..:...|....|..:.|..|      ..||..|.:...:::..... ..|.
Human  1543 DSPRSNSWRQP---PWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKT 1604

  Fly  1438 VTNG-----------SSINGNSSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLL 1491
            .|.|           .|.:.:.|..|.:..|||||:.||:|.:.|||        |||||||||.
Human  1605 STTGVATTQSPTPRSHSPSASQSGSQLRNRSVSGKRICSYCNNILGK--------GAAMIIESLG 1661

  Fly  1492 LFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
            |.||::||||..|...||...:|.:||:|||:|:|.:||
Human  1662 LCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCY 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950	24/160 (15%)
		PAT1	<1159..>1335	CDD:401645	34/184 (18%)
		LIM	<1494..1530	CDD:395333	17/35 (49%)
LMO7	XP_047286270.1	CH_SF	<42..100	CDD:469584
		DUF4757	213..>275	CDD:464950	10/72 (14%)
		DUF4757	627..774	CDD:464950	22/170 (13%)
		PDZ	1042..1110	CDD:214570	12/85 (14%)
		DUF5401	<1258..>1506	CDD:375164	66/315 (21%)
		LIM	1642..1700	CDD:259829	33/65 (51%)