DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Prickle4

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001277266.1	Gene:	Prickle4 / 381104	MGIID:	2685785	Length:	369	Species:	Mus musculus

Alignment Length:	252	Identity:	46/252 - (18%)
Similarity:	86/252 - (34%)	Gaps:	99/252 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1360 NNHWLLQ-----------------EAEQRRIEQLNRRSIPAS--KSMGKPLPD-----------S 1394
            |:.|.||                 ::.:|.:|.....|..|:  .|:|.|..|           :
Mouse     5 NSDWSLQQDNPIFREPDPPVYTDSDSGRRPVEDYEDTSAQAATCSSLGPPCLDINQVSNWPGFRT 69

  Fly  1395 IIQTLTERVQSKGIGDRKRFDSNGNYSQVNGN------NIYQQQQQQKNVTNG------SSINGN 1447
            ::|.|..:            ||:..|....|.      .::..|::||::..|      ..:.|.
Mouse    70 LLQQLPPQ------------DSDERYCLALGEEELAQLRLFCAQRKQKSLGQGVARLLPPKLEGY 122

  Fly  1448 SSQGQEKVL---------SVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCV 1503
            :.:..:|:|         :.:|::.|.|      :.|:  .|:.....:.:|:.|||.....|..
Mouse   123 TCKKCKKLLDPGEYGVFAARAGEQSCWH------RPCF--ACQACGQGLINLIYFYHEGHLYCGR 179

  Fly  1504 CHVQL-------------------GDGLNGTDVRVRNHKLH--CQNCYSSDDGIKFS 1539
            .|.:|                   .:|       .|.|:.|  ||:|....||.:::
Mouse   180 HHAELLRPRCPACDQLIFSQRCTEAEG-------QRWHENHFCCQDCAGPLDGGRYA 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	11/56 (20%)
Prickle4	NP_001277266.1	PET_OEBT	1..116	CDD:193603	22/122 (18%)
		LIM1_Testin_like	124..181	CDD:188726	12/64 (19%)
		LIM2_Testin_like	187..241	CDD:188727	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900