Protein Alignment smash and Lmo7

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_036014595.1
• Gene: Lmo7 / 380928
• MGIID: 1353586
• Length: 1807
• Species: Mus musculus
• Alignment Length: 1693
• Identity: 336/1693 - (19%)
• Similarity: 587/1693 - (34%)
• Gaps: 446/1693 - (26%)

  Fly    46 PYVTKQ----RVTRPTPPAPSKNPMQFVQIKPCNLYQTAQEQLKKAEEVKKLKEVKKEEPEEWQN 106
            |.:.|.    |...|..|:|..:..||:                               |:.|..
Mouse   342 PNIVKDDLYVRKLSPVMPSPGSSFDQFL-------------------------------PKCWTP 375

  Fly   107 NLDNWKSSRRKRVEHIIDRAVETKKLELEEHDRLRRKSKTFTE--------MMEERAERGGPR-- 161
            ...|||..:|           ||.|...:|....||.|.:..|        .:..|.|:...|
Mouse   376 EDMNWKKIKR-----------ETYKPWYKEFQGFRRNSDSENEDSGSFQSSTIFSRLEKADHRLD 429

  Fly   162 ----GRAKLASLAVYNEDETNDLSDLGIGTSSASGKSS------LSGDYDNNSVMSDHAAELDKA 216
                ..:.|..||..:...:.| :.....||||..:||      ....|.::.:.|:.:.:||..
Mouse   430 SSYQRPSLLLELATKHAMRSRD-THAARRTSSALQESSQFLLLQALQTYSDDILSSETSVKLDPT 493

  Fly   217 IGAA-------SSVAAGVTAQNVDEQLNHINRNGSNGNHGNGAAVGQTGPSNSSKSAGRQYISSP 274
            .|..       .|.|.|..|.  |.:|..::.:..|.:.    .|.:||..:::....|.:   .
Mouse   494 SGPRLITRRKNRSPAPGYRAH--DLELPALDPDLENDDF----FVRKTGAFHANPCVLRAF---E 549

  Fly   275 GYDTSSSNAQASSPDLCEYTYEG--AIQDYKQR---VQRASSNGNGNANGKLIG-----EHIAYP 329
            .:.:.|....|...|:.....||  .:.|.::.   |:|..:.   .....|.|     :.:.:|
Mouse   550 DFRSFSEPDDAVERDIILQCREGELVLPDLEKDDMIVRRIPAQ---KKEVPLSGAPDRYQPVPFP 611

  Fly   330 ----------------TRRGSKIEDRLSGFEVTSPSDTQE-------GVEKQKVD--VPKV---- 365
                            ..|....:::.||..|..||..|:       .::..|:.  ||.:
Mouse   612 EPWTLPPEIQAKFLSVLERTRPPKEQSSGCRVLVPSYRQKKDDMLARKIQSWKLGTAVPPISFKP 676

  Fly   366 ------DISKRKEIFEQAKAEVSNGGAPAAPKLVFRDGL-----------TNGNSATTAPKSEVR 413
                  |:.|.:.|:|             |.:|..|..|           .||:.:.:...:|
Mouse   677 GPCSEADLQKWEAIWE-------------ASRLRHRKRLMVERLFQKIYGENGSKSMSDVSAE-- 726

  Fly   414 RLSGDISSIR----DRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPLVALI 474
                |:.::|    :.||.::.|.|........|  :...|.|..|....:.|:::::..    |
Mouse   727 ----DVQNLRQVRYEEMQKIKSQLKEQDQKWQDD--LAKWKNRRKSYTSDLQKKKEEREE----I 781

  Fly   475 DARQLEIMRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPALIIEE---PPVADTNDDSGIQEDTA 536
            :.:.||......:..|:..| ::.|...|.....:......|:::   ||....::.|...|...
Mouse   782 EKQALEKSDRSSKTFREMLQ-DRESRGSTVTSWRRTYSSDDILDDGVLPPTVTLSETSYQSERLE 845

  Fly   537 DELQQQQQLNAAIAALALEE----RQLEEAANAVNQIEAEFDELTDLHPSPL-PPSPALPAVQQS 596
            ||.:      |..|.:..|:    ...|::..|..|:.:...|...|.|||. .|..|..:..:.
Mouse   846 DEAR------AHPAEMPKEDSTTFANREDSVVAETQLASHSPEEQRLAPSPSEEPRQASGSSAEP 904

  Fly   597 LQQPTVAQVPAQAVNQAAAPPLRDMEFSINEALELALQA--IDREATTKPMDKAQHPQKREQKEE 659
            .|.|.::..|.:....:..|....:..::.....|:.|.  ..|..:|:.........:|.....
Mouse   905 HQAPLLSTEPRRTPLPSEEPHQASLSSTLQRPSSLSSQQSWSTRAESTRISASLPRSYQRTDTAR 969

  Fly   660 LGGKPEEKEPICEEQHDEESNEQGETHNEG----GEMPNKTDKQMQGGR----EPIYENVSSTIS 716
            |......: |.........|..:..|.::|    |::.....:|:..||    :|   :.|..||
Mouse   970 LTSVVTAR-PFGTSSRGISSLPRSYTMDDGWKYNGDVEVVKREQLDLGRATGPKP---DSSHFIS 1030

  Fly   717 MHEVDNEQIATMTITTQTQAT----RISHRRSIPSQQTSNSNENNQSTNQTSNSRNQKESSTAAT 777
            ....:.|.|||..:.:.:..|    .:||.|::.|:.|.:|.....|.:.:...|
Mouse  1031 GSASEKEVIATEDVASLSSPTLPSSSLSHDRAVSSKATFSSMSGLDSVSDSGEGR---------- 1085

  Fly   778 SAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIF-------YSGLEISQGSV 835
                          ..|..:|.::.:.:.|....:...|  .|..:|       .||:.::....
Mouse  1086 --------------GSPLREVSRSLDQFSDMRVSINQTP--GNKPVFGFTIKWDISGIFVASVEQ 1134

  Fly   836 GAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDT--WSS--DNTYET--ISNG 894
            |:|...              |.:.:    |||:..:.|:.....||  |..  .|..||  :...
Mouse  1135 GSPAEF--------------SQLQV----DDEILAINNTKFSYKDTKKWEEVMANAQETGNLVMD 1181

  Fly   895 TRRHLQ---GQPEPAQPSPPIKRMNSTKRIKKELRNKRSSFL----GIENDGDLDDMETYLELTV 952
            .||:.:   |:.:|:.|....|.:|.|....|.:.:..:.::    ||.|    .|..:.|.:|.
Mouse  1182 VRRYGKSDWGKDQPSLPFIRHKTLNLTSVATKIIGSSETKWIDTTSGIYN----SDKSSSLSVTT 1242

  Fly   953 APPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDS-GVSENHSRQSSEHYT--------NSS 1008
                |.::.||......|::   .|:.:.|:..:|:.| .:|..:.::.|:.:.        :|.
Mouse  1243 ----DFSESLQSPYTESKEV---NGIHEESNPFDSKASESISLKNLKRRSQFFEQGWPGFSYSSW 1300

  Fly  1009 EENDTQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQS 1073
            ......|::..|.||.|..:|.......|.|             :....|.|.:
Mouse  1301 VYLCGSSDSVAPDLPVPTLSAPSRWAWDQEE-------------ERRRQERWQK----------- 1341

  Fly  1074 LSEATATANAKMQSIEDKIREQGEMLR--VERELLHFSQEELKRQREN---LVLRENIA---RRE 1130
              |.......|.|..::|:||:.:..:  .|||...:..|||.....|   |..||.:|   ...
Mouse  1342 --EQDRLLQEKYQREQEKLREEWQRAQQEAERENSKYLDEELMVLNSNSISLTSREPVAATWEAT 1404

  Fly  1131 LQHGAKMLMSNNRRSLQDLHHGLGIGNGMLS-----AFQPPQHHQVQMPPPHPQQIYANVPQQQQ 1190
            ...|:|.|.|...|:.::       ..|.|.     ..|..:..:::......:| .|...::::
Mouse  1405 WSEGSKSLDSEGTRAGEE-------DRGQLEDDAVYEDQSQKLQELEQEKKRKEQ-EAQEEERRK 1461

  Fly  1191 QMVLHAYHQMDTD-----YRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTR 1250
            |....|:.:.:..     ..::.::....:...........|...|.:|.|.   .|.:.:|...
Mouse  1462 QREAQAWAEAEAKAWAEAQARAEAEAKARAEAQARAEAEAQKRAEAQKLQAE---RERETSVKIY 1523

  Fly  1251 QRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPK 1315
            |.:.|         |....:|.|        :..|:.......:::.|....|..| :......|
Mouse  1524 QYRRP---------IDSYDLPKR--------EDDTSGMLPTDRSKSRSTTELNDPL-IEKNGSSK 1570

  Fly  1316 YAD--GWVQVQQRKSYDSQQTSDAAWLAAQQ-----QKRKSMPDYGGALYNNNHWLLQEAE---- 1369
            |::  |......|.|...|..|:|. |..||     :||.|       |:|:|.|:.|.:.
Mouse  1571 YSERIGATSFSHRSSKKDQAPSEAE-LERQQILQEMRKRTS-------LHNDNSWIRQRSASVNK 1627

  Fly  1370 --------QRRIEQLN----------RRS--------IPASKSM---GKPLPDSIIQTLTERVQS 1405
                    .||.|.|:          |:|        :.||.|:   .:| |..::.|
Mouse  1628 EPICLPGIMRRGESLDNLDSQRPGSWRQSPWHSQPAGVYASSSVQDFSRP-PPQLLST------- 1684

  Fly  1406 KGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGS--------SINGNSSQGQEKVLSVSGKK 1462
                      ||..|.: |.::...........:.||        |::.:.||.:.:  |||||:
Mouse  1685 ----------SNRAYMR-NPSSAVPPPAGSVKTSPGSPSPRSHSPSMSQSGSQLRNR--SVSGKR 1736

  Fly  1463 KCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQ 1527
            .||:|.:.|||        |||||||:|.|.||::||||..|...||...:|.:||:|||:|:|.
Mouse  1737 VCSYCNNILGK--------GAAMIIETLGLSYHLHCFKCVSCGCDLGGSSSGAEVRIRNHQLYCN 1793

  Fly  1528 NCY 1530
            :||
Mouse  1794 DCY 1796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950	21/117 (18%)
		PAT1	<1159..>1335	CDD:401645	27/187 (14%)
		LIM	<1494..1530	CDD:395333	17/35 (49%)
Lmo7	XP_036014595.1	CH_LMO7	14..129	CDD:409126
		DUF4757	242..>304	CDD:464950
		DUF4757	655..802	CDD:464950	30/172 (17%)
		PDZ	1116..1184	CDD:214570	16/85 (19%)
		LIM	1738..1796	CDD:259829	32/65 (49%)