DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and prickle1a

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_899185.2	Gene:	prickle1a / 368249	ZFINID:	ZDB-GENE-030724-5	Length:	793	Species:	Danio rerio

Alignment Length:	462	Identity:	93/462 - (20%)
Similarity:	152/462 - (32%)	Gaps:	153/462 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PR-GRAKLASLAVYNED-ETNDLSDLGIGT--------SSASGKSSLSGDYDNNSVMSDHAAELD 214
            || ||...:......|| :.:|.||....:        |...||||.|.|....|::
Zfish   302 PRQGRIYCSKACSLGEDVQASDSSDSAFQSARSRESRRSVKMGKSSRSADQCRQSLL-------- 358

  Fly   215 KAIGAASSVAAGVTAQNVDEQL-----------NHINRNGSNGNHGNGAAVGQTGPSNSSKSAGR 268
              ...||:......:.|.|:.|           ||..||..:          |..|.:.     .
Zfish   359 --FSPASNYKFPGLSGNADDTLSKRLSQLNFADNHFWRNRED----------QEAPEDH-----E 406

  Fly   269 QYISSPGYDTSSSNAQASSPDLCEYTYEGAIQDYK---------QRVQRASSNGNGNANGKL--- 321
            ::.....|.|..         |.::...|..||.:         :...:..|.||.:...|.
Zfish   407 EWAEHDDYMTQL---------LLKFGEHGMFQDTRTDLSIWTDSELKNKTCSGGNSSLASKKYKA 462

  Fly   322 ----------IGEHIAYPTRRGS-----------------KIEDRLSGFEVTSPSDTQEGVEKQK 359
                      :|:. ||.:..|.                 |.||....|     :|:.|.:..|
Zfish   463 DMYWTQSQDGLGDS-AYGSHPGPASSRKLQDLDLEHGASFKHEDNKQWF-----NDSLECITDQ- 520

  Fly   360 VDVPKVDISKRKEIFEQAKAEVSNGGAPAAPK---LVFR-------DGLTNGNSATTAPKSEVRR 414
              :.:.|::.|..:...|.:.::........|   |:|.       |...|.::..|. .|.::.
Zfish   521 --LKEADLNIRDSMDSLALSNITGASVDGDIKDKPLLFSLQKFSDLDRCENTSNMGTL-NSSMKS 582

  Fly   415 LSGDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQ--QSVAKEEQ------------ 465
            |:.|:    ||.|.:|:|::....|..|. |.||   ||..|:  :|.:|.:|
Zfish   583 LTSDL----DRTQVIEEQQEQGVPSPEVH-PKPP---RLPVLRRSKSQSKTQQVKFSDDVIDNGR 639

  Fly   466 ------KKPPLVALIDARQLEIMRGEEERMR--QQQQKEKHSPSQTTL-CAPKPAPPALIIEEPP 521
                  ::||:......|..:....:.:|.|  .::::.:.|.|...| .|||        ||.|
Zfish   640 YDELKVRQPPMSERTRRRAFQFDEQDHQRPRHHHRRRRSRMSRSDNALHLAPK--------EEKP 696

  Fly   522 VADTNDD 528
            .....||
Zfish   697 RVCFKDD 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
prickle1a	NP_899185.2	PET_Prickle	28..124	CDD:193602
		LIM1_Prickle	132..191	CDD:188799
		LIM2_Prickle	196..251	CDD:188802
		LIM3_Prickle	256..314	CDD:188804	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900