DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Fblim1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_008762495.1	Gene:	Fblim1 / 362650	RGDID:	1359551	Length:	552	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	85/410 - (20%)
Similarity:	134/410 - (32%)	Gaps:	159/410 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1155 IGNGMLSAFQPPQHHQ---VQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSN 1216
            :.||..|...||.:.:   :..|||.|...|..:|:::..:|..:         ..:|||.:
  Rat   255 LSNGGCSLPPPPLNEEDLDLLPPPPPPPSAYLPLPEEEPPVVPGS---------SLISDLEQ--- 307

  Fly  1217 CLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPI 1281
             |.||| ||..||  :|..:.|..::|. .|..|..:...|             ||       |.
  Rat   308 -LHLPP-PPPPPL--LQAPSKGSSVQPQ-PVQVRPSEEELP-------------PP-------PE 347

  Fly  1282 QAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQK 1346
            :..|.|  ..:::.::.....          ||        |..|:            ||.:..|
  Rat   348 EPVTLP--EREASTDVCGFCH----------KP--------VSPRE------------LAVEAMK 380

  Fly  1347 RKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQTLTER-------VQ 1404
            |:    |....:.......|.|.||..::           .|:||.:...|...|:       ||
  Rat   381 RQ----YHAQCFTCRTCRRQLAGQRFYQK-----------DGRPLCEPCYQDTLEKCGKCGEVVQ 430

  Fly  1405 S---KGIGDRKRFD-------------SNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQE 1453
            .   :.:|  |.|.             |:.:::..|.|.:|       .||:          ...
  Rat   431 EHVIRALG--KAFHPPCFTCVTCARCISDESFALDNQNQVY-------CVTD----------FYR 476

  Fly  1454 KVLSVSGKKKCSHCGDEL----GKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNG 1514
            |...|     ||.|.:.:    ||..:.:.|.|..         :|.||::|..|.|.|  .:..
  Rat   477 KFAPV-----CSICENPIIPRDGKDAFKIECMGRN---------FHENCYRCEDCSVLL--SVEP 525

  Fly  1515 TDVRVRNHKLHCQNCYSSDD 1534
            ||          |.||..:|
  Rat   526 TD----------QGCYPLND 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
Fblim1	XP_008762495.1	LIM	<357..415	CDD:295319	16/102 (16%)
		LIM2_FBLP-1	422..474	CDD:188758	11/70 (16%)
		LIM3_Zyxin_like	482..543	CDD:188743	20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900