DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and Scel

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006252490.1	Gene:	Scel / 361086	RGDID:	1305102	Length:	672	Species:	Rattus norvegicus

Alignment Length:	929	Identity:	165/929 - (17%)
Similarity:	290/929 - (31%)	Gaps:	335/929 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   666 EKEPICEEQHDEESNEQGETHNEGGEMPNKTDKQMQGG-------REPIYENVSSTI-SMHEVDN 722
            :|.|:   .:|.:|.:......:|....||....:|..       .|...||....: |.|...:
  Rat     8 KKSPV---GNDPKSTQGAALRQQGFHDVNKRRAFLQDNSWIKKLPEEEKDENYGRVVLSRHNSHD 69

  Fly   723 EQIATMTITTQTQATRISHRRSIPSQQTSNSNENNQSTNQTSNS-RNQKESSTAATSAANPVPPT 786
            .....:|...:.:|| ||..||      .:..:.:.||.:|..| :....||.:|.:.|...|.|
  Rat    70 ALDRKITERDEPKAT-ISRYRS------EDMLDRSLSTFRTPESTKTPAGSSFSANTTAPSTPAT 127

  Fly   787 TPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPP 851
            ||         |.|..:.::                                          |||
  Rat   128 TP---------VKKKRQSWF------------------------------------------PPP 141

  Fly   852 PPTESPIPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRR-----HLQGQPEPAQPSPP 911
            ||                      |||...          |.|..|     |   .|.|.:|..|
  Rat   142 PP----------------------GHNAPP----------STGASRRDPPLH---PPLPPKPCSP 171

  Fly   912 IKRMNSTKRIKKELRNKRSSFLGIENDGD--------LDDMETYLELTVAPPPDMAQLLQEERRL 968
            |.   |.|::::..|....:..|...:.|        .:|::..:.:..|              |
  Rat   172 IA---SPKQLRQSHRQMHMATAGACGEADRHAARNIRTEDLDDIIRVAAA--------------L 219

  Fly   969 EKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTN------SSEENDTQSEATPPPLPPPPS 1027
            :|           :|.||..|:.:..|.|...::....      .:::.|.::::.
  Rat   220 QK-----------TDKGEELDNLIRMNKSLNRNQGLDGLFRANLKAQQLDKRAQSL--------- 264

  Fly  1028 TAQVGEVIYQNESLLAAQTPLLQTVKGNSA---------ESWTESAT---AAAAATQSLSEATAT 1080
                       |||:...|.:.:..|||.|         .:.||..:   .:...|.:::|.::.
  Rat   265 -----------ESLIYMNTQMDRDGKGNQAFGSFKKINQRADTERGSQDQRSIIRTNAMAERSSR 318

  Fly  1081 ANAKMQSIEDKI-----------REQGEMLRVERELLHFSQEELKRQR--ENL------VLRENI 1126
            ....:.|:. ||           ::.|.::.|..|    :.:.:||.:  |||      |.|.:.
  Rat   319 RGKDLDSVM-KISPKGHESATGKQDLGGLINVNPE----TNKSMKRGQSLENLIKVTLEVNRSSK 378

  Fly  1127 ARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGML---SAFQPPQHHQVQMPPPHPQQIYANVPQQ 1188
            ..:.|.:..|.:.:.:|.:    ....|:.:.|.   ||.:..||...::....|:.:...
  Rat   379 GGQSLDNFIKAVPATDRAN----QGSQGLDSLMKVTPSANKSNQHSLDELVNTSPKAVKTT---- 435

  Fly  1189 QQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQ 1253
                   |.||          ||::|                 :::||:        .::..||.
  Rat   436 -------AGHQ----------DLDKF-----------------IKVNAD--------VLTNNQRN 458

  Fly  1254 PPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYAD 1318
            .....     .|.|.|...|.                 ..:.:|.|:.:....||..|...:...
  Rat   459 HDLDN-----SIRGNPTVNRC-----------------DQSHDLDNLIKVKPSALRNTNGDQDLK 501

  Fly  1319 GWVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPA 1383
            |..:|..|.|.|..:..|..........||..|  ..::|::.               .:.|:.:
  Rat   502 GLTEVNSRVSEDKNERVDGQANGVTNSLRKESP--RTSVYSHE---------------TKTSLSS 549

  Fly  1384 SKSMGKPLP-DSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGN 1447
            :.......| |:::.|.|....||...|..:.:.:|.|.|    .:|....:
  Rat   550 NSGTRNAGPKDTVVYTRTYVENSKSPKDGYQENISGKYIQ----TVYSTSDR------------- 597

  Fly  1448 SSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGL 1512
                     ||..:..|::|...||.        ...||::.|.:..|..||||.:|...|.:..
  Rat   598 ---------SVIERDMCTYCRKPLGV--------ETKMILDELQICCHSTCFKCEICKRPLENLQ 645

  Fly  1513 NGTDVRVRNHKLHCQNCYS 1531
            .|..:.:....:||:.|||
  Rat   646 AGDSIWIYRQTIHCEPCYS 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
Scel	XP_006252490.1	LIM	604..662	CDD:214528	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900