DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and jub

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	171/862 - (19%)
Similarity:	259/862 - (30%)	Gaps:	354/862 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 SHRRSIPS------QQTSNSNENNQSTNQTSNSRNQ------KESSTAATSAANPVP----PTTP 788
            |::|| |.      |::....:.:|.........||      :.:..||:..|.|.|    ..|.
  Fly    55 SYQRS-PGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKLYERGNIIAASKYATPRPVEQIQHTH 118

  Fly   789 GEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEI--------SQGSVGAPV--G--L 841
            ...|:.|....:.........||   .|||||:| ||...:.        |.||..:.:  |  |
  Fly   119 NGSAQIYAPTAQILGQRIAPQKH---SPVYENLE-FYGQFDSNHKRAQPQSPGSRQSAILNGYLL 179

  Fly   842 MEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPA 906
            |:|.:   ......:|:|.::|                          :.|.||.|...|.|.|
  Fly   180 MQPIR---AGRFAHTPVPENQG--------------------------SASLGTTRAAGGPPPP- 214

  Fly   907 QPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETYLELTVAP----------PPDMAQL 961
                                :.||:.||  ..|||::....:...:.|          .|..|.:
  Fly   215 --------------------SGRSAALG--PTGDLEEHAAPIYENIIPHSGQRAQPQASPATATM 257

  Fly   962 LQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPPLPPPP 1026
            .||.:.            .|:.:|.|..:|:..|....|..|..:.|....:.|....|
  Fly   258 YQEMQP------------TSNSSGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSP------ 304

  Fly  1027 STAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDK 1091
             |.:     |:|.||.:..:|:                            .||.:.||:|. ...
  Fly   305 -TQR-----YRNLSLPSHLSPV----------------------------PTAQSVAKLQQ-HTP 334

  Fly  1092 IREQGEMLRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHH--GLG 1154
            ::..|..:                   |:.:..|.. .::.....:.|:.|      ||.  ..|
  Fly   335 VKSPGGAI-------------------NVSVNPNYI-EDINSSDYVCMTAN------LHRNTAAG 373

  Fly  1155 IGNGMLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLI 1219
            :..|..:|...|....||.||.....:...:                               ...
  Fly   374 LATGRAAATGAPAQRTVQEPPIITSSLAMGM-------------------------------ATA 407

  Fly  1220 LPPT----------PPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRL 1274
            .|||          .|..|.....|.|....:....||:|    .|.|..||..  ..|.:.||
  Fly   408 APPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLAVAT----SPTPSQGSTA--VNAALKPR- 465

  Fly  1275 PGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAW 1339
                                   ..:::| ||..|.||
  Fly   466 -----------------------RGLTKN-LLPYSVTP--------------------------- 479

  Fly  1340 LAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRR---SIPASKSMGKPLPDSIIQTLTE 1401
                  .|.:.|              .|| ||:||:|.|:   .|..|:..|:..  .|..|..|
  Fly   480 ------PRPAGP--------------TEA-QRKIEELTRQLEEEIEQSEEHGEYF--GICHTCGE 521

  Fly  1402 RVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTN-------GSSINGN---SSQGQ---E 1453
            :|  ||.|..         .|..| |:|.        ||       |.::.|.   :..|:   |
  Fly   522 KV--KGAGQA---------CQAMG-NLYH--------TNCFICCSCGRALRGKAFYNVHGRVYCE 566

  Fly  1454 KVLSVSG----KKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNG 1514
            :....||    .:||:.||..:           ..||::::...||..||:||||:..| ||:..
  Fly   567 EDYMYSGFQQTAEKCAICGHLI-----------MEMILQAMGKSYHPGCFRCCVCNECL-DGVPF 619

  Fly  1515 T-DVRVRNHKLHCQNCY 1530
            | ||   :||::|.|.|
  Fly   620 TVDV---DHKIYCVNDY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	18/36 (50%)
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	16/72 (22%)
		LIM2_Ajuba_like	581..633	CDD:188741	23/66 (35%)
		LIM3_Ajuba_like	641..702	CDD:188822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900