DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and Lpp

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_038944025.1	Gene:	Lpp / 288010	RGDID:	1310535	Length:	797	Species:	Rattus norvegicus

Alignment Length:	1033	Identity:	176/1033 - (17%)
Similarity:	276/1033 - (26%)	Gaps:	472/1033 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 LPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSINEALELALQAIDREATTK---P-MDKAQH 650
            ||:.:..||:   ...|....:....||           ..|.::.:.|.|.|:   | |||...
  Rat     2 LPSPRPLLQE---VHCPGSPTSSRGCPP-----------RPLPVRLVRRPAGTRLPIPYMDKCVQ 52

  Fly   651 PQKREQKEELG---------------GKPEEKEP--------------ICEEQHDEESNEQGETH 686
            .:...|..::.               |:.|.:.|              :|.......|:..|.:.
  Rat    53 AKSGIQAPDVSLQRSGHRTGDRGKGVGRKEGRAPTSSHSRPAAEVSLFVCGFAPRARSSFPGISS 117

  Fly   687 NEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQIATMTITTQTQATRISHRRSIPSQQTS 751
            ..|||     .:.:|||         :|.|..||:.   |:..:......|.:|.|..:|.
  Rat   118 VSGGE-----SRPLQGG---------NTGSRTEVER---ASQVLLHLLLFTVVSPRDIVPQ---- 161

  Fly   752 NSNENNQSTNQTSNSRNQKESSTAATSAANP--VPPTTPGEQAEPYYQVPKATEPYYDAPKHLRP 814
                                   ..::.::|  :||.:.|   ||...||...|..:
  Rat   162 -----------------------LISTMSHPSWLPPRSTG---EPLGHVPARMETTH-------- 192

  Fly   815 VPVYENVEIFYSGLEISQGSVGAPVGLMEPPKE------------------------KPPPPPTE 855
                            |.|:....|...:|||:                        .|||||.|
  Rat   193 ----------------SFGTPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLE 241

  Fly   856 SP--IPLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPP------- 911
            .|  ||...||                                         ..|.||
  Rat   242 DPGTIPSGSGH-----------------------------------------FPPPPPLDEGAFI 265

  Fly   912 IKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYIKA 976
            ::|.|..   .|.|..:|||.     |.::|.:.:.|          |.|
  Rat   266 VQRGNPG---GKTLEERRSSL-----DAEIDSLTSIL----------ADL--------------- 297

  Fly   977 GLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNESL 1041
                                  :.|..|...:....:.|.|:||...|         |......:
  Rat   298 ----------------------ECSSPYKPRAPPGSSSSIASPPVSTP---------VTGHKRMV 331

  Fly  1042 LAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELL 1106
            :..|.||..|.|         |||                  |.|:|...:...|
  Rat   332 IPQQPPLTATKK---------SAT------------------KPQAIPIPVTPIG---------- 359

  Fly  1107 HFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGML--------SAF 1163
                 .||.|.:.:....:.|....:....:.:.:.:.|   .|:..|..:|.:        :..
  Rat   360 -----TLKPQPQPVPASYSTASTSSRPAFNVQVKSAQPS---THYMTGSSSGQMYGPGSRSYNTQ 416

  Fly  1164 QPPQHHQVQMPPPH--PQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNE--FSNCLILPPTP 1224
            |.|.  ..|.|||.  ....||.:|...||.      :....|..:.....|  |:.|.......
  Rat   417 QVPL--SAQCPPPTTCAGTDYAYIPPSGQQA------ESGFGYTSNQGRYFEPFFAACPSYGGRN 473

  Fly  1225 PTKPLRAMQLNANGHGLEPDYAV--STRQRQPPAPYGGSLVKIAGAPMPPRLPGQGY---PIQAP 1284
            ...|....|:..|....||.||.  :..|.||      .:..::|       |.:.|   |:.||
  Rat   474 EADPAYGQQVQPNTWKREPGYAAPGAGNQNQP------GMYSVSG-------PKKTYITDPVSAP 525

  Fly  1285 TAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQKRKS 1349
            .||.                                ||.::|              ..:.||
  Rat   526 CAPP--------------------------------VQPKER--------------LVKNQK--- 541

  Fly  1350 MPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKP------LPDSIIQTLTERVQSKGI 1408
                          :||.....|:..|.:...||  .||.|      .|:..::.||:::
  Rat   542 --------------VLQNVVDDRVHGLRKSGFPA--PMGPPSVPPSFRPEDELEHLTKKM----- 585

  Fly  1409 GDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSGKKKCSHCGDE-LG 1472
                               :|..:....:...|                     :|:.||:. :|
  Rat   586 -------------------LYDMENPPADDYFG---------------------RCARCGENVVG 610

  Fly  1473 KLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
            :   ..||.....:       :|::||.|.||.::    |.|........|.:|:.||
  Rat   611 E---GTGCTAMDQV-------FHVDCFTCMVCDIK----LRGQPFYAVEKKAYCEPCY 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	10/35 (29%)
Lpp	XP_038944025.1	PHA03247	<15..429	CDD:223021	108/647 (17%)
		dnaA	347..>534	CDD:237605	47/257 (18%)
		LIM1_TRIP6	601..654	CDD:188736	16/66 (24%)
		LIM	661..720	CDD:413332
		LIM3_TRIP6	721..786	CDD:188820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900