DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Prickle2

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006506169.1	Gene:	Prickle2 / 243548	MGIID:	1925144	Length:	937	Species:	Mus musculus

Alignment Length:	331	Identity:	73/331 - (22%)
Similarity:	126/331 - (38%)	Gaps:	64/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1124 ENIARRELQHGAKMLMSNNR--RSLQDLHHGLGIGNGMLSAFQPPQHHQV-------QMPPPHPQ 1179
            :|...:|.:..||:..:..:  .::.:.|..|.:.:..|||...|...|:       |.|..:..
Mouse   419 QNARAKESRRSAKIGKNKGKTEEAMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRD 483

  Fly  1180 QIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPD 1244
            .|:     :.::...|..::|:.:  :|.|.|...|.|.|.....|         ...|.|.:||
Mouse   484 PIW-----RSREEPFHYGNKMEQN--QSQSPLQLLSQCNIRTSYSP---------GGQGAGAQPD 532

  Fly  1245 Y---AVSTRQRQPPAP---YGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRN 1303
            .   ..|..:|.....   :|||.::        ......||.:..:..:|...|:|:. |.:|.
Mouse   533 MWAKHFSNPKRSSSMALKGHGGSFIQ--------ECREDYYPGRLMSQESYSDMSSQSF-NETRG 588

  Fly  1304 TLLALSATPKPKY------ADGWVQVQQ---RKSYDS-QQTSDAAWLAAQQQKRKSMPDYGGALY 1358
            ::      |.|||      .:|.:..||   |:...| :.|.|..  ..:|..|.||....   .
Mouse   589 SI------PVPKYEEEEEEEEGGISTQQCRPRRPLSSLKYTEDMT--PTEQTPRGSMESLA---L 642

  Fly  1359 NNNHWLLQEAEQRRIEQLNRRSIP-ASKSMGKPLPDSI--IQTLTERVQSKGIGDRKRFDSNGNY 1420
            :|...|..|...:|.|.|:|.|:| .||..|..:.:.:  :.||...:|.:.....:...|...|
Mouse   643 SNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQY 707

  Fly  1421 SQVNGN 1426
            .::.||
Mouse   708 QEMEGN 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
Prickle2	XP_006506169.1	PET_Prickle	118..214	CDD:193602
		LIM1_Prickle	222..280	CDD:188799
		LIM2_Prickle	285..340	CDD:188802
		LIM3_Prickle	345..403	CDD:188804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900