DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and Tesl1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001030036.2	Gene:	Tesl1 / 236749	MGIID:	3648288	Length:	411	Species:	Mus musculus

Alignment Length:	293	Identity:	57/293 - (19%)
Similarity:	94/293 - (32%)	Gaps:	111/293 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1327 KSYDSQQTSDAAWLAAQQQK-----------RKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRS 1380
            |..|:..|....|:.:.|.|           ::..|..|           .|..|.|.:|| .:.
Mouse    93 KKNDAINTVTYDWIPSVQNKALARQYMQMLPKEKQPVTG-----------SEGAQYRKKQL-AKQ 145

  Fly  1381 IPA-----SKSMGKPLPD-SIIQTLTERVQSK--GIGDRKR-FDSNGNYSQVNGNNIYQQQQQQK 1436
            :||     ||..|....: ..::...|:.:|:  |:|:.|| .|.|....:|:         ...
Mouse   146 LPAHDQDPSKCHGLSYNEIKKMKQFVEKYKSEALGVGNVKRPSDMNAQGDKVH---------NPA 201

  Fly  1437 NVTNGSSINGNSSQGQEK---------------------VLSVSGKKK--------CSHCGDELG 1472
            .:.|.:::.|:..:.:|.                     ....:|..|        ||.||:.|.
Mouse   202 GIRNSTAVVGSKDKSKESKKTQYTCYCCKHPMKEGDPAIYAERAGYSKLWHPACFICSICGEILV 266

  Fly  1473 KLCY-------YVG----------CRGAAMIIESLLLF-----------YHINCFKCCVCH---- 1505
            .:.|       |.|          |.|.     ..|:|           :|:..|.|..||
Mouse   267 DMIYFWKNGKLYCGRHYCDSEKPRCSGC-----DELIFSNEYTQAENKNWHLKHFCCIDCHNILA 326

  Fly  1506 ----VQLGDGLNGTDVRVRNHKLHCQNCYSSDD 1534
                |.|..........::||.:.||.|:::.|
Mouse   327 GKIYVMLKSKPVCKPCYMKNHAVVCQGCHNAID 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	11/43 (26%)
Tesl1	NP_001030036.2	PET_testin	101..188	CDD:193604	21/98 (21%)
		LIM1_Testin	226..283	CDD:188797	10/56 (18%)
		LIM2_Testin	289..344	CDD:188800	11/59 (19%)
		LIM3_Testin	351..409	CDD:188803	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900