DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and LIMCH1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_011511944.1	Gene:	LIMCH1 / 22998	HGNCID:	29191	Length:	1655	Species:	Homo sapiens

Alignment Length:	1851	Identity:	367/1851 - (19%)
Similarity:	597/1851 - (32%)	Gaps:	636/1851 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PYVTKQRVTRPTPPAPSKNPMQFVQ------------IKPCNLYQTAQE-QLKKAEEVKKLKEVK 97
            |.:.|:....|||.|...|.:.|::            ..|.:|..|:.. .:|..:..:|||.|.
Human    63 PGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKSLDYSRKLKNVL 127

  Fly    98 KEEPEEWQNNLDNWKSSRRKRVEHIIDRAVETKKLELEEHDRLRRKSKTFTEMME---------- 152
              ....|.....|..:|            .....|.|:|.:.|..:.:..|:.:|
Human   128 --VTIYWLGKAANSCTS------------YSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSG 178

  Fly   153 -------ERAERGGP--RGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSS---LSGDYDNNSV 205
                   ||::...|  .||           |::.|..| ..|:.|....|.   |.|..|...
Human   179 YIDCWDSERSDSLSPPRHGR-----------DDSFDSLD-SFGSRSRQTPSPDVVLRGSSDGRG- 230

  Fly   206 MSDHAAELDKAIGAASSVAAGVTAQNVDEQLNHIN-RNGSNGNHGNGAAVGQTGPSNSSKSAGRQ 269
             ||..::|..             .:..|.:.:.:: |..|:|...:.....|..|:.|:::|
Human   231 -SDSESDLPH-------------RKLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTA--- 278

  Fly   270 YISSP-------------GYDTSSSNAQASSPDLCEYTYEGAIQDYKQRVQRASSN---GNGNAN 318
            |:.:|             .:.|::|......|    :::...|::....|..|..:   |..|..
Human   279 YVPAPLRKKKAEREEYRKSWSTATSPLGGERP----FSFPETIEEEGSEVGSAGEDNPAGQMNPG 339

  Fly   319 GKLIGEHIAYPTRRGSKIEDRLSGFE-------VTSPSDTQEGVEKQKVDVPKVDISKRKEIFEQ 376
            .|        |:..|.::.|. ||.|       |.:|:...|  ||.     ..:|.|||.: ||
Human   340 WK--------PSDGGCELPDG-SGKEHPSSDGAVVAPAPKSE--EKD-----AAEIQKRKRL-EQ 387

  Fly   377 AKAEVSNGGAPAA-----------PKLVFRD-GLTNGNSATTAPKSEVRRLSGDISSIRDRMQSL 429
            |..:|    .|||           .|...|| .|...||..|..........|::..   |:..|
Human   388 AGIKV----MPAAQRFASQKQLSEEKEAIRDIVLRKENSFLTHQHGNDSEAEGEVVC---RLPDL 445

  Fly   430 EQ-----QRKAFSSSKSVDVPVPPLKQRLNS--LQQSVAKEEQKKPPLVALIDARQLEIMRGE-- 485
            |:     :|...:.:|    |:.||.|.|..  .::...|.:..|.....:...|.||..|.:
Human   446 EKDDFAARRARMNQTK----PMVPLNQLLYGPYPKKGAEKSDGSKQLSKGISKKRSLEYKRNQGH 506

  Fly   486 -EE-------RMRQQQQK------------EKHSPSQTTL---CAPKPAPPALIIEEPPVADTND 527
             ||       .||.|:.:            .|...:|..:   .||...||:.|.
Human   507 TEEVKLIVTCNMRAQESEPVEGGLRKVPDLHKDDLAQQRIQGSLAPHREPPSFIT---------- 561

  Fly   528 DSGIQEDTADELQQQQQLNAAIAALALEERQLEEAANAVNQIEAEFDELTDLHPSPLPPSPALPA 592
               :...|..:|:..::|..:           |:|.:...|           |.....|||.:.|
Human   562 ---LSNITEADLETWERLKVS-----------EKARDGDVQ-----------HICASEPSPEIKA 601

  Fly   593 VQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSINEALELALQAIDREATTKPMDKAQHPQKREQK 657
              ::..:...|...|:|..:|::|..:.:.|.....|:                  |...||...
Human   602 --ETAIRDDFANRKARASKKASSPRQKFVHFGPVTELD------------------QQKWKRLSI 646

  Fly   658 EELGGKPEEKEPIC---EEQHDEESNEQGETHN-EGGEMPNKTD--KQMQGGREPIYENVSSTIS 716
            .:.|.:.:|:|.||   :.|.|..|.....|.: :|.::.|:.:  :.|..||.......|....
Human   647 GKAGPREDEEEVICHGSKIQMDSVSPVSAATSSLKGHQIFNRQNDCRTMNCGRGDYCRRASWLAP 711

  Fly   717 MHEVDNEQI--------ATMTITTQTQATRISHRRSIPSQQTSNSNENNQSTNQTSNSRNQKESS 773
            :.|...|.:        .|..:|::              |...:..|..:|..:.|...::.|.|
Human   712 VPESQEEWVCSLGECPRGTEEVTSK--------------QLPQDGKEETESAPRDSERLSKAERS 762

  Fly   774 TAATSAANPV--PPTTPGEQAEPYYQVPKATEPYYDA---------------------------- 808
               ..::.|:  |..:..|.:....::.|.|.|.:..
Human   763 ---EDSSQPLVCPLASECEASGTEEKLEKMTAPAWSGSGLKGQRKLDDSRKDDMMARRTGMSLRH 824

  Fly   809 ----PKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPT--------------- 854
                |....|||       |....::.:.|.|.|   |:..:..|..|.:
Human   825 TGSNPNQFLPVP-------FAKQQDVEESSKGLP---MKDQRYGPRTPVSDDAESTSMFDMRCEE 879

  Fly   855 ESPI-PLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNST 918
            |:.: |......::|..:.|.|....|.|..|                          :.|..|.
Human   880 EAAVQPHSRARQEQLQLINNQLREEDDKWQDD--------------------------LARWKSR 918

  Fly   919 KR------IKKELRNKRSSFLGIENDGDLD---DMETYLELTVAPPPDMAQLLQEERRLEKQLYI 974
            :|      ||||...|:...|....||..:   .::||.|           ::||:.|.|::|:
Human   919 RRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYRE-----------IVQEKERRERELH- 971

  Fly   975 KAGLCDSSDTGESRDSGVSENHSRQSSEHYT------------------NSSEENDTQSEATPPP 1021
                 ::.....|::.  :|...:|..|.:|                  :|:|.|.:.....|.|
Human   972 -----EAYKNARSQEE--AEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFLNDPNP 1029

  Fly  1022 --------LPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEAT 1078
                    ||||..||.|...|        |:..:|.|  ..||.|.:.|.|....|...|:...
Human  1030 MKYLRQQSLPPPKFTATVETTI--------ARASVLDT--SMSAGSGSPSKTVTPKAVPMLTPKP 1084

  Fly  1079 ATANAKMQ------SIEDKIREQGEMLRVERE------------------------LLHFSQEEL 1113
            .:.....|      .::.|:...||.:..|.|                        .:|.|..||
Human  1085 YSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSPLEL 1149

  Fly  1114 KRQRENL---VLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLS-AFQPPQHHQVQMP 1174
            |:...::   :.:.|...:||   |.........|.:|.:.|.....|.:. |...|||....:.
Human  1150 KQDNGSIEINIKKPNSVPQEL---AATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQHFTTTVT 1211

  Fly  1175 PPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLN-----EFSNCLILPPTPPTKPLRAMQL 1234
            ...|...:...|...|   |......:.|.:|..::::     ..|..::.|.:|
Human  1212 RCSPTVAFVEFPSSPQ---LKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKSP---------- 1263

  Fly  1235 NANGHGLEPDYAVS--TRQRQPPA-----PYGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQ 1292
                   ||:..::  ...:.|.|     |...|......|.:|.|:.......|      :..|
Human  1264 -------EPEATLTFPFLDKMPEANQLHLPNLNSQESPGTASVPLRVQNSWRRSQ------FFSQ 1315

  Fly  1293 SAQNLSNMSRNTLLALSATPKPKY-----------ADGWVQVQQR---KSYDSQQTS-DAAWLAA 1342
            |..:.|:.....:     ||:.|:           .:.|.|.|:|   :.|..:|.. ...|..|
Human  1316 SVDSPSSEKSPVM-----TPQFKFWAWDPEEERRRQEKWQQEQERLLQERYQKEQDKLKEEWEKA 1375

  Fly  1343 Q-----------QQKRK-----------------------SMPDYGGAL-----------YNNNH 1362
            |           :::||                       ||.:..|.:           ..:..
Human  1376 QKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRR 1440

  Fly  1363 W-----------LLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQTLTERVQSKGIGDRKRFDS 1416
            |           ||:..|..|:|:....:..|....|.|:             |||:.:..:.|:
Human  1441 WKKSFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSGNPV-------------SKGVHEDHQLDT 1492

  Fly  1417 NGNYSQVNGN-NIYQ---QQQQQKNVTNGS------------SIN-------------------- 1445
            .........| .:.|   |.||..|.|:.|            |||
Human  1493 EAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKTLPLDKSINHQIESPSERRKKSPREHFQA 1557

  Fly  1446 -----------GNSSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCF 1499
                       |.|....::  |:||||.||.||..|||        |||||||:|.|::||.||
Human  1558 GPFSPCSPTPPGQSPNRYKR--SISGKKLCSSCGLPLGK--------GAAMIIETLNLYFHIQCF 1612

  Fly  1500 KCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
            :|.:|..||||.::|||||:||..|:|.:||
Human  1613 RCGICKGQLGDAVSGTDVRIRNGLLNCNDCY 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571	24/118 (20%)
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	19/35 (54%)
LIMCH1	XP_011511944.1	CH	26..138	CDD:237981	17/76 (22%)
		DUF4757	250..>311	CDD:292571	12/67 (18%)
		DUF4757	813..961	CDD:292571	33/194 (17%)
		GBP_C	<1340..1377	CDD:303769	8/36 (22%)
		LIM	1585..1642	CDD:214528	35/64 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007310
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4167
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930