Protein Alignment smash and lim-8

DIOPT Version :9

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_741201.1
• Gene: lim-8 / 175952
• WormBaseID: WBGene00017904
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 1587
• Identity: 302/1587 - (19%)
• Similarity: 491/1587 - (30%)
• Gaps: 640/1587 - (40%)

  Fly    58 PPAPSKNPMQFVQIKP--CNLYQTAQEQLKKAEEVKKLKE---------VKKEEPEEWQNNLDNW 111
            |...|.:|.|||.:..  ..:.::|:..|:.|::.|..:|         :|.::.|.||.|||.|
 Worm    35 PGQKSSDPFQFVAVNKGGDEMAESAKSTLQMAQQQKAQREKMLQGQKQTLKFDDCEPWQENLDTW 99

  Fly   112 KSSRRKRVEHIIDRAV-ETKKLELEEHDRLR-------RKSKTFTEMMEERAERGGPRGR-AKLA 167
               |:||.|...|||. :|...|...|.|..       ||||.....:...:....||.. |...
 Worm   100 ---RKKRKEKFGDRATSDTTVPETTIHRRSEEYTSYQPRKSKEEILQVNSASRPALPRQHSASTV 161

  Fly   168 SLAVYNEDETNDLSDLGIGTSSASGKSSLSGDYDNNSVMSDHAAELDKAIGAASSVAAGVTAQN- 231
            |....:.||.|  :|.||               ||.:|.|...:|.     :..|....|:.::
 Worm   162 SPLQSSSDELN--NDSGI---------------DNRTVGSPSTSEF-----SPRSTDLFVSPKSI 204

  Fly   232 VDEQLNHINRNGSNGNHGNGAAVGQTGPSNSSK----------SAGRQYISSPGYDTSSSNAQAS 286
            :||:..|         |      ....|....|          |.|:.|  :|.|.:
 Worm   205 IDEEPPH---------H------PPPPPPVEEKLDQVLIPLKLSRGQDY--APIYRS-------- 244

  Fly   287 SPDLCEYTYEGAIQDYKQRVQRASSNGNGNANGKLIGEHIAYPTRRGSKIEDRLSGFEVTSPSDT 351
               |.:.||      |.|                                          |||::
 Worm   245 ---LEQDTY------YDQ------------------------------------------SPSES 258

  Fly   352 QEGVEKQKVDVPKVDISKRKEIFEQAKAEVSNGGAP---AAPKLVF-----RDGLTNGNSATTAP 408
            ::..:        :.::..|...|..::...|...|   |..:..|     |:|:
 Worm   259 EKDED--------LGLTNTKRYTENFRSVEKNQYMPVMSARVEATFKQPPPREGV---------- 305

  Fly   409 KSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPLVAL 473
            |..|.|.:.||:            ....|..:::|:.:     .||..|:  |.....|.|....
 Worm   306 KPFVSRAAQDIT------------HNGESKVENIDLTI-----ELNREQK--ATVTATKYPRTDF 351

  Fly   474 IDARQLEIMRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPALIIEEPPVADTNDDSGIQEDTADE 538
            |                   .::.|.| ||.:.||.|..|
 Worm   352 I-------------------MEDYHRP-QTQILAPAPKKP------------------------- 371

  Fly   539 LQQQQQLNAAIAALALEERQLEEAANAVNQIEAEFDELTDLHPSPLPPSPALPAVQQSLQQPTVA 603
                                 .......:.::..|||         .|:...|......|:
 Worm   372 ---------------------NSTTRIYHAVDIPFDE---------SPASYYPKQNNGYQR---- 402

  Fly   604 QVPAQAVNQAAAPPLRDMEFSINEALELALQAIDREATTKPMDKAQ--HPQKREQK----EELGG 662
                |....|::...:|..|::|..:           .::|:.|..  ...||:::    ..:.|
 Worm   403 ----QRRYSASSASKQDGMFTLNVIM-----------GSQPVHKGMGFSTVKRDERVIVESVIVG 452

  Fly   663 KPEEKEPICEEQHDEESNEQGET--HNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQI 725
            .|.:|..:.          .|:|  ...|.||   :||...|....::|    ...:.|.|
 Worm   453 SPADKAGLL----------VGDTILSINGEEM---SDKYQSGVTRILHE----AARVGEAD---- 496

  Fly   726 ATMTITTQTQATRISHRRSIPSQQTSNSNE------NNQS-------------TNQTSNSRNQKE 771
             .:.:.....|..:|.:.|..|..:||.::      .|:|             |::.|||.|...
 Worm   497 -VLILRAPVPAPMLSKQMSTSSSNSSNYDKARSVFTENKSFDSYAEFKRKHTRTSRDSNSSNATR 560

  Fly   772 SSTAATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVG 836
            ||                   ..:..:|:.|                           .:|.|
 Worm   561 SS-------------------RDFNSLPRGT---------------------------TAQSS-- 577

  Fly   837 APVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLG------NSLGHNTDTWSSDNTYETISNGT 895
                                   ||...|..|....      ||..:.:...|....|. :||..
 Worm   578 -----------------------LDRKRDTSLSSYRTAKDNFNSSSNRSSGRSEYGDYR-VSNYQ 618

  Fly   896 RRHLQGQPEPAQPSPP--IKRMNSTKRI------KKELRNKRSSFLGIEN--------DGDLDDM 944
            .::..|:.....|...  :.|...::.|      .:|.|..|:..|..||        ||..|..
 Worm   619 EKNAPGRLTDFVPEVDRRLSRREQSEEIYSRSQRDEEPRTIRNYHLSNENIARTNLNYDGRRDSE 683

  Fly   945 E----TYLELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGE-----SRDSGVSENHSRQS 1000
            |    |.|:.|..|....||...|             ..|..:..|     ||||....:..::|
 Worm   684 EESTTTTLKRTTLPRSGTAQWKNE-------------YSDGEEVTEKLPVTSRDSSPLRSALKKS 735

  Fly  1001 SEHYTNSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESAT 1065
            |.:|.:.|.:          |:.|||..      .|..||        ||..|.:|.:.::|.
 Worm   736 SHNYYHQSSD----------PVAPPPRR------YYSTES--------LQLPKTSSYQRYSEE-- 774

  Fly  1066 AAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQRENLVLRENIARRE 1130
                                                |.|.:..:...::|.|:.:
 Worm   775 ------------------------------------EDEEIEETYSSMRRHRQEI---------- 793

  Fly  1131 LQHGAKMLMSNNRRSLQDLHHGLGIGN-GMLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQM-- 1192
                        .|.:.:.|   .:|: |::     ||..:.|.|...|:  |.:||....::
 Worm   794 ------------PRHVDEFH---TVGSYGVM-----PQRSRSQQPARLPR--YDSVPDDVDEVSG 836

  Fly  1193 VLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAP 1257
            |.|.::....::.::                 |.:.:..:|:                ||.
 Worm   837 VSHRFYDRSGNHVRA-----------------PRERIHDIQI----------------QRD---- 864

  Fly  1258 YGGSLVKIAGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQ 1322
            ||.                     :||:......::.........:|.:..:.....|.:..|..
 Worm   865 YGD---------------------RAPSRDLDFVRNTYKWEEQLEDTKVTTTTKIYEKESRDWRD 908

  Fly  1323 V--QQRKSYDSQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASK 1385
            |  |||::... .::|...:||......::|.|               ..||:|:...|.|...:
 Worm   909 VINQQRQAAPG-NSADRRGIAATSSSLSNLPSY---------------INRRMEKEREREIEYRR 957

  Fly  1386 SMGKPLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVN---------GNNIYQQQQQQKNVTNG 1441
            .....:|.:....:||:.:            ...||:|.         .|.:.:::.|.:  ::.
 Worm   958 DREYSMPPADPPVITEKYE------------RDEYSRVEERTYPVPVARNKMRREETQMQ--SSL 1008

  Fly  1442 SSINGNSSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHV 1506
            ..::..|||..:.|::||||.:|:||.:|||        ||||||:|||.||||:.||||.||..
 Worm  1009 QQMHSQSSQKDDSVVAVSGKHRCAHCNEELG--------RGAAMIVESLNLFYHLACFKCYVCKT 1065

  Fly  1507 QLGDGLNGTDVRVRNHKLHCQNCYSSD 1533
            .||.|..|.|||||:.:||||.|||:|
 Worm  1066 SLGSGATGADVRVRDGRLHCQTCYSND 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571	34/112 (30%)
		LIM	<1494..1530	CDD:278823	21/35 (60%)
lim-8	NP_741201.1	PDZ	431..489	CDD:238080	15/74 (20%)
		LIM	1030..1088	CDD:214528	38/65 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_116595
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4167
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940