DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and PRICKLE1

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001138353.1	Gene:	PRICKLE1 / 144165	HGNCID:	17019	Length:	831	Species:	Homo sapiens

Alignment Length:	616	Identity:	104/616 - (16%)
Similarity:	205/616 - (33%)	Gaps:	185/616 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 FEQAKAEVSNGGAPAAPK---------LVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQSL 429
            |..|:.:.|..|.|..||         ....:.:...:|:.:|.:|...|.|.....:....:|.
Human   279 FSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSA 343

  Fly   430 EQQRKAFSSSKSVDVPVP--------PLKQRLNSLQ-----QSVAKEEQKKPPLVALIDARQLEI 481
            :|.|::...|.:::...|        .|.::|:.|.     .|.|.||..|.
Human   344 DQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKG------------- 395

  Fly   482 MRGEEERMRQQQQKEKHSPSQTTLCAPKPAPPALIIEEPPVADTN------DDSGIQEDTADELQ 540
             |.|:|.....::...|....|.|.. |....:|...:|...|..      .|:.::..|  ||:
Human   396 -RVEQETPEDPEEWADHEDYMTQLLL-KFGDKSLFQPQPNEMDIRASEHWISDNMVKSKT--ELK 456

  Fly   541 QQQQLNAA---------------------------IAALALEERQLEEAANAVNQIEAEFDE--- 575
            |..|..|:                           .::..|:|.:|:..|:..|..|.::.|
Human   457 QNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSL 521

  Fly   576 --LTDLHPSPLPPSPALPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSINEALELALQAIDR 638
              |:||.|.        .:|:.|:....::.:...:|:....|  |...:|:....|:..:..::
Human   522 ECLSDLKPE--------QSVRDSMDSLALSNITGASVDGENKP--RPSLYSLQNFEEMETEDCEK 576

  Fly   639 EATTKPMDKAQHPQKREQKEELGGK-------PEEKE---PICEEQHDEESNEQGETHNEGGEMP 693
            .:....::.:...:..|..:.|..:       ||||.   |:......:...:|.:..::
Human   577 MSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDD----- 636

  Fly   694 NKTDKQMQGGREPIYENVSSTISMHEVD-NEQIATMTITTQTQATRISHRRSIPSQQTSNSNENN 757
                         :.:|.:..|.:.:.. :|:........:.:.:|..|.|...|:::.:.|..|
Human   637 -------------VIDNGNYDIEIRQPPMSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALN 688

  Fly   758 QSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVY-ENV 821
            ..|.:..:.:::....|.              :..|.:.|           .|..|.:..| :|.
Human   689 LVTERKYSPKDRLRLYTP--------------DNYEKFIQ-----------NKSAREIQAYIQNA 728

  Fly   822 EIF--YSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSL---GHNTDT 881
            :::  |:       ...:..||..|                         |:...|   |.:.|:
Human   729 DLYGQYA-------HATSDYGLQNP-------------------------GMNRFLGLYGEDDDS 761

  Fly   882 W--SSDNTYETISNGTRRHLQGQPEPAQPSP 910
            |  ||.::.::...|   :..|||.| ||.|
Human   762 WCSSSSSSSDSEEEG---YFLGQPIP-QPRP 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823
PRICKLE1	NP_001138353.1	PET_Prickle	22..118	CDD:193602
		LIM1_Prickle_1	126..184	CDD:188867
		LIM2_Prickle	189..244	CDD:188802
		LIM3_Prickle	249..307	CDD:188804	7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..342		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831		10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900