Protein Alignment smash and smash

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_003435847.1
• Gene: smash / 1281694
• VectorBaseID: AGAMI1_000467
• Length: 1311
• Species: Anopheles gambiae
• Alignment Length: 1757
• Identity: 420/1757 - (23%)
• Similarity: 606/1757 - (34%)
• Gaps: 682/1757 - (38%)

  Fly    20 SATSSTNGGD-----TNGCGKKLSVTSPDPTPYVTKQRVTRPTPPAPSKNPMQFVQIKPCNLYQT 79
            :||||.|...     ||......:....:...::.|.||||..||.|:.:|:|||||||..||..
Mosquito     2 AATSSNNSNSNSISPTNNNNNNNNNVHIETDEFIKKSRVTRAAPPKPAYDPLQFVQIKPAKLYDP 66

  Fly    80 AQEQLK-----KAEEVKKLKEVKKEEPEEWQNNLDNWKSSRRKRVEHIIDRAVETKKLELEEHDR 139
            ::...|     |.:|||..:||  |:.||||.||||||||||||||||||:..|.||:|.||..|
Mosquito    67 SKANNKPSTERKQQEVKPPREV--EDAEEWQCNLDNWKSSRRKRVEHIIDKITEAKKIEQEEVCR 129

  Fly   140 LRRKSKTFTEMMEERAERGGPRGRAKLASLAVYNEDE-------TNDLSDLGIGTSSASGKSSLS 197
            .|:|||||:||:    |..|.|.|..|..    |||:       ::||.|       .:..|...
Mosquito   130 ARKKSKTFSEML----ENSGSRRRFILPE----NEDDDEGANFSSDDLHD-------PTDTSKQQ 179

  Fly   198 GDYDNNSVMSDHAAELDKAIGAASSVAAGVTAQNVDEQLNHINRNGSNGNHGNGAAVGQTGPSNS 262
            ..|.:.|. .|.|.  |......||..|...::..||:|:         .||:...|
Mosquito   180 QQYKDEST-DDRAT--DDTSSCCSSKHADGDSKAADEELD---------EHGSAREV-------- 224

  Fly   263 SKSAGRQYISSPGYDTSSSNAQASSPDLCEYTYEGAIQDYK------QRVQRASSNGNGNANGKL 321
                                     |::.|::.  ||::||      |....:::||:...:| :
Mosquito   225 -------------------------PEMNEFSL--AIENYKSKFPMTQSTSTSTTNGSSRVSG-V 261

  Fly   322 IGEHIAYPTRRGSKIEDRLSGFEVTSPSDTQEGVEKQKVDVPKVDISKRKEIFEQAKAEVSNGGA 386
            :|..|.......|.:   :|..|.||
Mosquito   262 LGSSIVTTATTSSSV---VSSIESTS--------------------------------------- 284

  Fly   387 PAAPKLVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQS----LEQQRKAFSSSKSVDVPVP 447
                    .|...:.|||  ..:|:|    .::..:..::||    :|..|:....|..: |.|.
Mosquito   285 --------NDNYESNNSA--GEESDV----AEVERVTQKLQSTGLLVEATRREERRSTPL-VTVQ 334

  Fly   448 PLKQRLNSLQQSVAKEEQKKP------------PLVALIDARQLEIMRGEEERMRQQQQKEKHSP 500
            |::.|: .|||...:|||::.            |.|.:|:.|:|      .|:::|.......:.
Mosquito   335 PMESRM-QLQQEQEQEEQEEKQAKQQEQCQEERPKVNVIERRRL------FEQLQQMAHTTTPAV 392

  Fly   501 SQTTLCAPKPAPPALII-----EEPPVADTNDDSGIQEDTADELQQQQQLNAAIAALALEERQLE 560
            :.||........|:...     |.||     :::|:..|:.  ....:.|.|.||::. |.|.:.
Mosquito   393 ADTTPSGVAKLTPSATFAGGQQERPP-----EETGVDGDSG--TSTSEWLAAGIASIR-ERRAIF 449

  Fly   561 EAANAVNQIEAEFDELTDLHPSPLPPSPALPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSI 625
            |...:...|..|.|                   |||.|||.:....:::.:..|...:.......
Mosquito   450 ERYQSNEMIAEEHD-------------------QQSQQQPLLVGGRSRSSSTTATTVVVKSRSES 495

  Fly   626 NEA--------LELALQAIDREATTKPMDKAQHPQKREQKEELGGKPEEKEPICEEQHDEESNEQ 682
            |..        .||||..:.|..                    ||..:    .|     |:|..|
Mosquito   496 NVGFVNGSTGRFELALNQLKRNG--------------------GGSSD----CC-----EDSGIQ 531

  Fly   683 GETHNEGGEMPNKTDKQMQGGREPIYENVSSTISMHEVDNEQI----ATMTITTQTQATRISHRR 743
            ..|......:.::.|           ||...::|:...|...:    :....||...|:..|...
Mosquito   532 STTDLSRSSVVSQAD-----------ENDPPSLSLLSPDEMMLMAGKSPARSTTLDSASEFSDTD 585

  Fly   744 SIPSQQTSN----------SNENNQSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAEPYYQV 798
            ....|...|          |..|...|.:.:.|:.::|.|.:..:..:.||.:.          :
Mosquito   586 CSNGQLLDNALDVAFEEMDSELNESGTVEGALSQREREPSVSQPAETDIVPLSV----------I 640

  Fly   799 PKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPIPLDE- 862
            |.||:....:.:|.:.:.:                 :..|...:.||||||||||.|.. |.::
Mosquito   641 PLATDYMPASEEHQQQLVL-----------------MALPQSSLTPPKEKPPPPPVEEE-PTEQE 687

  Fly   863 --------------------------------GHDDELDGLGNSLGHNTD---------TWSSDN 886
                                            |.|...||:|..: ||:|         .|.|..
Mosquito   688 LLQSLTTRGAIITSWMEKGAAMHTHANGNGHHGDDPNADGIGMMM-HNSDHRQQQYEDEQWRSLE 751

  Fly   887 TYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETY---L 948
            :||.:.....:..|.|.:..:.             :||.          |.|.|..:|..|   :
Mosquito   752 SYEVVQQVVHQQQQLQQQQQEQ-------------EKEQ----------ERDKDQHEMMVYSNRI 793

  Fly   949 ELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDT 1013
            |      |.:|..||:::  ::|||         |.||..
Mosquito   794 E------PALAHHLQQQQ--QQQLY---------DPGEHE------------------------- 816

  Fly  1014 QSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEAT 1078
                                                                             
Mosquito   817 ----------------------------------------------------------------- 816

  Fly  1079 ATANAKMQSIEDKIREQGEMLRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNR 1143
                              |::.||||||...||||:|:||..:..|.:.:.:....|.     ..
Mosquito   817 ------------------EIVSVERELLQIEQEELQRRREKQMFYEKLTKADAAAAAA-----GT 858

  Fly  1144 RSLQDLHHGLGIGNGMLSAFQPPQHH-----------QVQMPP----PHPQQIYANVPQQQQQ-- 1191
            |::.|            .|..||.||           |.|..|    |..|.:....||||||
Mosquito   859 RAVTD------------PAQPPPPHHHHHQPQHSNQLQQQSQPVQQSPLVQSVRQAPPQQQQQQQ 911

  Fly  1192 -----------MVLHAYHQMDTDYRKSMSDLNEFSNCLILPPTPPTKPLRAMQLNANGH------ 1239
                       ...|.:|.:...:|.||                |....|::| |.|.:
Mosquito   912 QPYYYPHHHSHQPSHLHHNLLHHHRASM----------------PAMDSRSLQ-NVNSYASYDAP 959

  Fly  1240 --------GLE------------PDYAVSTRQRQPPAPYG-----GSLVKIAGAPMPPRLPGQGY 1279
                    |.|            .:.|.|:......:.||     .|.....|:..||.:.....
Mosquito   960 FLDEVVNSGYEMGSLHRESMPNLSNVAASSSHPSSLSSYGEEFSANSAASFDGSCWPPAIDHHRG 1024

  Fly  1280 PIQAPTA------PAYHHQSAQNLSNMSRNTLLALSATPKPKYADGW-------------VQVQQ 1325
            |...|.|      ||...:.|.|            .:.|......|:             ...:|
Mosquito  1025 PTGHPGAALFDKRPAVAPRPAMN------------GSLPPGAAVGGYHGGGGGGGQRVSNSMFEQ 1077

  Fly  1326 RKSYDSQQTSDAAWLAAQQQKRKS-------MPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPA 1383
            ....:.|.|..:|.:..:.|...|       || ||      .|||:||||||||||..:.|...
Mosquito  1078 HPKDNKQNTHPSAMVVNRGQGGSSSSGGTNHMP-YG------QHWLVQEAEQRRIEQHQKSSTNN 1135

  Fly  1384 SKSMGKPLPDSIIQTLTERVQ-----SKGIGDRKRFDSNGNYSQVNGNNIY-------------- 1429
            :|   :|||..:|..:|:|||     |....||.....:.:.:.:|....:
Mosquito  1136 AK---RPLPKFVIDAITQRVQKLNAASPENSDRSNLSEDSDLAMINSMKNHHHHHASMPPPPSSH 1197

  Fly  1430 ----------QQQQQ----------QKNVTNGSSINGNSSQGQEKVLSVSGKKKCSHCGDELGKL 1474
                      |||||          |:..:|.|          :|||||||||:||||..||||
Mosquito  1198 HHHAHLPHQQQQQQQPPALPALPPPQQKYSNTS----------DKVLSVSGKKECSHCRIELGK- 1251

  Fly  1475 CYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCYSSDDGIKFS 1539
                   ||||.||||.|||||.|||||||||:||||.||.|||||.::||||||:||:||:|||
Mosquito  1252 -------GAAMAIESLGLFYHIECFKCCVCHVKLGDGTNGIDVRVRKYRLHCQNCFSSEDGVKFS 1309

  Fly  1540 CV 1541
            ||
Mosquito  1310 CV 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950	63/110 (57%)
		PAT1	<1159..>1335	CDD:401645	47/253 (19%)
		LIM	<1494..1530	CDD:395333	28/35 (80%)
smash	XP_003435847.1	DUF4757	<28..143	CDD:464950	65/119 (55%)
		LIM	1242..1299	CDD:214528	12/62 (19%)