DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and WTIP

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_011524754.1	Gene:	WTIP / 126374	HGNCID:	20964	Length:	472	Species:	Homo sapiens

Alignment Length:	330	Identity:	65/330 - (19%)
Similarity:	99/330 - (30%)	Gaps:	132/330 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 RKSMSDLNEFSN----CLILPPTPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKI 1265
            |.|:|.|....:    ...|||.....|.|:                       |.|.|.:...:
Human   141 RSSVSSLGSRGSAGAYADFLPPGACPAPARS-----------------------PEPAGPAPFPL 182

  Fly  1266 AGAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYD 1330
            ...|:||...|      .|:|      :.:.|..::|....||.|.....|....::. ....|.
Human   183 PALPLPPGREG------GPSA------AERRLEALTRELERALEARTARDYFGICIKC-GLGIYG 234

  Fly  1331 SQQTSDAAWLAAQQQKRKSMPDYGGALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSI 1395
            :||...|.                |:||:.:.:                   ...|.|:.|....
Human   235 AQQACQAM----------------GSLYHTDCF-------------------TCDSCGRRLRGKA 264

  Fly  1396 IQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSG 1460
            ...:.|:|                |.|  .:.:|...||..:
Human   265 FYNVGEKV----------------YCQ--EDFLYSGFQQTAD----------------------- 288

  Fly  1461 KKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLH 1525
              |||.||..:           ..||:::|...||..||:|.||:..| ||:..| |.|.|: ::
Human   289 --KCSVCGHLI-----------MEMILQALGKSYHPGCFRCSVCNECL-DGVPFT-VDVENN-IY 337

  Fly  1526 CQNCY 1530
            |...|
Human   338 CVRDY 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	15/35 (43%)
WTIP	XP_011524754.1	LIM1_Ajuba_like	225..278	CDD:188738	14/106 (13%)
		LIM2_Ajuba_like	290..342	CDD:188741	22/65 (34%)
		LIM	350..404	CDD:295319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900