DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and Zyx

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006236450.1	Gene:	Zyx / 114636	RGDID:	620698	Length:	666	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	144/777 - (18%)
Similarity:	214/777 - (27%)	Gaps:	319/777 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   777 TSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGL 841
            |.||...||......:.|.:..|:.......|||        ..|..|..|...|..:.||....
  Rat   102 TMAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPK--------PKVNPFRPGDSESPVAAGAQRAQ 158

  Fly   842 MEPPKEKPPPPPTESPIP----LDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQ 902
            |....|.|||||.:.|:|    :.||.|.| ..||.:.                          .
  Rat   159 MGRVGEIPPPPPEDFPLPPPPVIGEGDDSE-GALGGAF--------------------------P 196

  Fly   903 PEP----AQPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQ 963
            |.|    .:|.||..                     :|.|           :..:|||.    |:
  Rat   197 PPPPPLIEEPFPPAP---------------------LEED-----------IFPSPPPP----LE 225

  Fly   964 EERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYTNSSEENDTQSEATPPPLPPPPST 1028
            ||...|                                                .|..|||.| .
  Rat   226 EEGGPE------------------------------------------------APTQLPPQP-R 241

  Fly  1029 AQVGEVIYQNESLLAAQTPLLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIR 1093
            .:|..:..:.:||    :.||..:..|       ....|..::..:....||......|.:.
  Rat   242 EKVSSIDLEIDSL----SSLLDDMTKN-------DPFKARVSSGYVPPPVATPFVPKPSTKP--- 292

  Fly  1094 EQGEMLRVERELLHFSQEELKRQRENLVLRENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNG 1158
                                                                       ..:|..
  Rat   293 -----------------------------------------------------------APVGTA 298

  Fly  1159 MLSAFQPPQHHQVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYR-KSMSDLNEFSNCLILPP 1222
            .|..::.|...|   |||.        ||.:.|:.|||..|.....: :|:|..|
  Rat   299 PLPPWKAPSSSQ---PPPQ--------PQAKPQVQLHAQPQAKPHVQPQSVSSAN---------- 342

  Fly  1223 TPPTKPLRAMQLNANGHG-LEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQAPTA 1286
            |.|..||......|.... :.|.:.....:..|.||.|       ..|.|.:   :..|::||::
  Rat   343 TQPRGPLSQAPTPAPKFAPVAPKFTPVASKFSPGAPSG-------PGPQPSQ---KSVPLEAPSS 397

  Fly  1287 PAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQQQKRKSMP 1351
            ..                    :.:|:|   ..:...||::....|:........||.|.:...|
  Rat   398 VG--------------------TGSPQP---PSFTYAQQKEKPLVQEKQHPLPPPAQNQNQVRSP 439

  Fly  1352 DYGGALYNNNHWLLQEAEQRRIEQL-----------NRRSIPASKSMGK---PL--PDSIIQTLT 1400
            ...|.|      .|:|.|:  :|||           .|:|:..::|.||   ||  ....::.|
  Rat   440 GGPGPL------TLKEVEE--LEQLTQQLMQDMEHPQRQSVAVNESCGKCSQPLARAQPAVRAL- 495

  Fly  1401 ERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEKVLSVSGKKKCS 1465
                             |....:.....:|.|||              .|||: ..|:.|...|.
  Rat   496 -----------------GQLFHITCFTCHQCQQQ--------------LQGQQ-FYSLEGAPYCE 528

  Fly  1466 HCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRV-RNHKLHC 1526
            .|..:..:.|...|......::.:....||.:||.|.||...    |.||...| :.::.||
  Rat   529 GCYTDTLEKCNTCGQPITDRMLRATGKAYHPHCFTCVVCACP----LEGTSFIVDQANQPHC 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	13/34 (38%)
Zyx	XP_006236450.1	LIM1_Zyxin	445..531	CDD:188735	26/126 (21%)
		LIM2_Zyxin	538..597	CDD:188739	15/53 (28%)
		LIM3_Zyxin	598..664	CDD:188819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900