DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smash and Wtip

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_997095.1	Gene:	Wtip / 101543	MGIID:	2141920	Length:	398	Species:	Mus musculus

Alignment Length:	341	Identity:	80/341 - (23%)
Similarity:	111/341 - (32%)	Gaps:	124/341 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1222 PTPPTKPLRAMQL--------NANGHGLEPDYAVSTRQRQPPA---PYGGSLVK---------IA 1266
            |..|::|.|..:.        :|...|:...|    .||..|.   |.|||...         .|
Mouse    62 PDVPSRPERGPRASLAGSDGGSARSSGISLGY----DQRHGPGPGPPSGGSARSSVSSLGSRGSA 122

  Fly  1267 GAPMPPRLPGQGYPIQAPTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDS 1331
            ||......||.|      .|||...:.||        ....|.:.|.|...:|.....:|:....
Mouse   123 GACADLLPPGVG------PAPARSPEPAQ--------FPFPLPSLPLPPGREGGPSAAERRLEAL 173

  Fly  1332 QQTSDAAWLAAQQQKRKSMPDYGG-------ALYNNNHWLLQEAEQRRIEQLNRRSIPASKSMGK 1389
            .:..:.|..|      ::..||.|       .:|.        |.|            |.::||
Mouse   174 TRELERALEA------RTARDYFGICIKCGLGIYG--------ARQ------------ACQAMG- 211

  Fly  1390 PLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNGSSINGNSSQGQEK 1454
                |:..|           |....||.|.  ::.|...|       ||       |.....||.
Mouse   212 ----SLYHT-----------DCFICDSCGR--RLRGKAFY-------NV-------GEKVYCQED 245

  Fly  1455 VLSVSG----KKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGT 1515
            .| .||    ..|||.||..:           ..||:::|...||..||:|.||:..| ||:..|
Mouse   246 FL-YSGFQQTADKCSVCGHLI-----------MEMILQALGKSYHPGCFRCSVCNECL-DGVPFT 297

  Fly  1516 -DVRVRNHKLHCQNCY 1530
             ||   ::.::|...|
Mouse   298 VDV---DNNIYCVRDY 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	14/36 (39%)
Wtip	NP_997095.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..166		29/121 (24%)
		LIM1_Ajuba_like	193..246	CDD:188738	19/104 (18%)
		LIM2_Ajuba_like	258..310	CDD:188741	21/66 (32%)
		LIM3_Ajuba_like	318..379	CDD:188822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900