DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smash and LIMS4

DIOPT Version :9

Sequence 1:	NP_001246912.1	Gene:	smash / 40583	FlyBaseID:	FBgn0263346	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001358269.1	Gene:	LIMS4 / 100288695	HGNCID:	39941	Length:	398	Species:	Homo sapiens

Alignment Length:	94	Identity:	24/94 - (25%)
Similarity:	43/94 - (45%)	Gaps:	26/94 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1460 GKKKCSH--------CGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCHVQLGD-GLNGT 1515
            |:|.|.|        |..:.|:  :.:|     .:|:::...:|..||:|.:|...|.| |.
Human   117 GRKYCEHDFQMLFAPCCHQCGE--FIIG-----RVIKAMNNSWHPECFRCDLCQEVLADIGF--- 171

  Fly  1516 DVRVRNHKLH-CQNCYSSDD--GI-KFSC 1540
               |:|...| |:.|::.:.  |: |:.|
Human   172 ---VKNAGRHLCRPCHNREKARGLGKYIC 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	14..152	CDD:292571
smash	NP_001246912.1	LIM	<1494..1530	CDD:278823	12/37 (32%)
LIMS4	NP_001358269.1	LIM1_PINCH	72..130	CDD:188717	4/12 (33%)
		LIM2_PINCH	133..184	CDD:188718	15/63 (24%)
		LIM3_PINCH	197..247	CDD:188719	1/1 (100%)
		LIM4_PINCH	253..306	CDD:188720
		LIM5_PINCH	314..367	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900