Protein Alignment smash and lmo7

DIOPT Version :10

• Sequence 1: NP_001246912.1
• Gene: smash / 40583
• FlyBaseID: FBgn0263346
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_031752950.1
• Gene: lmo7 / 100216219
• XenbaseID: XB-GENE-949056
• Length: 1843
• Species: Xenopus tropicalis
• Alignment Length: 1593
• Identity: 295/1593 - (18%)
• Similarity: 495/1593 - (31%)
• Gaps: 649/1593 - (40%)

  Fly    79 TAQEQLK----KAEEVKKLKEVKKEEPEEWQNNLDNWKSSRRKRVEHIIDRAVETKKLELEEHDR 139
            ||.|.:.    :.||::|::...:::.::||::|..|||.|:.....:..:..|.::||...::.
 Frog   759 TADELISNRQVRFEELQKIRTQLQDQDQKWQDDLAKWKSRRKSFTSDMQKKKEEREELEKISYES 823

  Fly   140 LRRKSKTFTEMMEERAERGGPRGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSSLSGDYDNNS 204
            ..|..|||.||.:||                     ||.:..:..:...|:..:...|   .|:.
 Frog   824 PERTYKTFREMQQER---------------------ETRNQDNYYMSKESSEDRKMYS---SNDD 864

  Fly   205 VMSDHAAE--LDK----AIGAASSVAAGVTA-QNVDEQLNHINR-----------NGSNGNHGNG 251
            |..|..::  |::    |:.|..|:..|.:: ||.:.....|:.           :|:..:..|.
 Frog   865 VFGDAPSKRMLERSYTVAVEAPYSMGKGTSSVQNKENDRGVISELLPTSNSTFETDGTYSSKANT 929

  Fly   252 AAVGQTGPSNSSKSAGRQYISSPGYDTSSSNAQASSPDLCEYTY---EGA-IQDYKQRVQRASS- 311
            :.|.| ||.||:....|                    .|.|.||   .|| ..:.|:.:...:|
 Frog   930 SYVEQ-GPENSNTKTSR--------------------SLFERTYTVESGAPYSNKKETIHSITSY 973

  Fly   312 ----NGNGNANGKLIGEHIAYPTRRGSKIEDRLSGFEVTSPSDTQEGVEKQKVDVPKVDISKRKE 372
                ||....:..|:||..:|            |.|  .:.|....|:........|.|.|:...
 Frog   974 EKQDNGPPMNSSSLLGEQHSY------------SSF--VTESKPIPGLASLPRSYQKNDTSRITS 1024

  Fly   373 IFEQAKAEVSNGGAPAAPKLVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQSLEQQRKAFS 437
            :.......:.:.|..:.|:....|              :..:.:||:.|.::        ..||:
 Frog  1025 VVTPRPFGIQSKGITSLPRSFTVD--------------DSFKYNGDLGSTKN--------NSAFN 1067

  Fly   438 SSKSVDVPVPPLKQRLNSLQQSVAKEEQKKPPLVALIDARQLEIMRGEEERMRQQQQKEKHSPSQ 502
            |...|:       ::.|.:::|   ||..:|               .|:|.:|:     .||
 Frog  1068 SYIKVE-------EKPNRIKRS---EENDEP---------------DEKESIRR-----SHS--- 1099

  Fly   503 TTLCAPKPAPPALIIEEPPVADTNDDSGIQEDTADELQQQQQLNAAIAALALEERQLEEAANAVN 567
                 |||.|                 |:                   :.|.|:|.:.|:.|..:
 Frog  1100 -----PKPFP-----------------GV-------------------SAAPEKRIISESVNVTS 1123

  Fly   568 QIEAEFDELTDLHPSPLPPSPALPAVQQSLQQPTVAQVPAQAVNQAAAP-PL---RDMEFSINE- 627
            .                                      |:.|:|...| ||   .|:..|||:
 Frog  1124 S--------------------------------------ARGVDQTKVPGPLDQYSDLRISINQK 1150

  Fly   628 ---ALELALQAI--DREATTKPMDKAQHPQKREQKEELGGKPEEKEPICEEQHDEE--------- 678
               :|:...:..  ......|.:|.              |.|.|   .|:...|:|
 Frog  1151 PGSSLDFGFKTSWNSSGVFVKSVDI--------------GSPAE---FCQLHVDDEILSVNGTKV 1198

  Fly   679 ----SNEQGETHNEGGEMPN-KTDKQMQG----GREP---IYENVSSTISMHEVDNEQIATMTIT 731
                .|:..|..:...|..| ..|.:..|    ||:|   .|:: ..|:::..:|.:.|
 Frog  1199 SSMDYNQWVEAMDHAVETGNLAMDVRRYGKNDWGRDPPSLPYKS-HKTLNLTSMDTKLI------ 1256

  Fly   732 TQTQATRISHRRSIPSQQTSNSNEN---NQSTNQTSNSRNQKESSTAATSAANPVPPTTPGEQAE 793
                                .|.||   :.|.:|:::.:.....|..|.|..|.:..:||.|...
 Frog  1257 --------------------GSPENKWIDASRSQSTSLKKDVPDSGNARSQLNGIQDSTPKESES 1301

  Fly   794 PYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQGSVGAPVGLMEPPKEKPPPPPTESPI 858
            ...:..|....:::                        |||..:.:              .:.|:
 Frog  1302 ISLKNYKRRSQFFE------------------------QGSSDSSL--------------LDMPV 1328

  Fly   859 PLDEGHDDELDGLGNSLGHNTDTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKK 923
            |                              :|:..|||  ...||           :..||.:|
 Frog  1329 P------------------------------SINVSTRR--SWDPE-----------DERKRQEK 1350

  Fly   924 ELRNKRSSFLGIENDGDLDDMETYLELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESR 988
            .|:                              :..|:|||:.:.|::
 Frog  1351 WLQ------------------------------EQEQILQEKYKREQE----------------- 1368

  Fly   989 DSGVSENHSRQSSEHYTNSSEE------NDTQSEATPPPLPPPPSTAQVGEVIYQNESLLAAQTP 1047
                      |..|.:..:.:|      :..|.|.....||                  :.:|:.
 Frog  1369 ----------QLREEWERAQQEAEKERFHQIQQEQVHSSLP------------------ITSQSS 1405

  Fly  1048 LLQTVKGNSAESWTESATAAAAATQSLSEATATANAKMQSIEDKIREQGEMLRVERELL------ 1106
            ..:|. |:...|..|.                  |.:.:|.|:::..:.:..|.|.|.|
 Frog  1406 YWKTF-GSDLHSSEEE------------------NRQKESSEEELESERQWKRAEEERLKYLEAQ 1451

  Fly  1107 -HFSQEELKRQRENLVLR-----ENIARRELQHGAKMLMSNNRRSLQDLHHGLGIGNGMLSAFQP 1165
             |...||.:||.|....|     ||..|:..:...:.....|.|..|:...........|.....
 Frog  1452 RHHEVEEQRRQLEEETNRRQTEEENRRRQAEEENRRRQAEENERKRQEEERKRKEEEMRLQRAAE 1516

  Fly  1166 PQHHQVQMPPPHPQQ-----IYA--NVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPPT 1223
            .:.||.::.....:|     ||.  ||..:...     ||                        |
 Frog  1517 EERHQKKLQEEEQKQNASERIYGRNNVGLESDD-----YH------------------------T 1552

  Fly  1224 PPTKPLRAMQLNANGHGLEPDYA-----VSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYPIQA 1283
            |           .||....|.|.     :...|::....:..|.|       |..|..:...|..
 Frog  1553 P-----------GNGISGRPKYGLAHWLIEDEQKRKNTKFSQSSV-------PSELEAKRKQIFN 1599

  Fly  1284 PTAPAYHHQSAQNLSNMSRNTLLALSATPKPKYADGWVQVQQRKSYDSQQTSDAAWLAAQ---QQ 1345
            .......::.....|..|.:|                ..||||..  .:|...:|.:..|   |:
 Frog  1600 QMKYPERYRGDHTDSGTSEDT----------------GNVQQRPY--REQLQGSAEVERQRIIQE 1646

  Fly  1346 KRKSMPDYGGALYNNNHWLLQEAE------------QRRIEQLNR-------------------- 1378
            .||..|     |.|:|.|:.|.:.            .||.|.|:.
 Frog  1647 MRKKAP-----LNNDNSWIRQRSSSMTKEASTLPNYMRRGESLDNLDSTSGLQRVSPWANQSSSY 1706

  Fly  1379 RSIPASKSMGKPLPDSIIQTLTERVQSKGIGDRKRFDSNGNYSQVNGNNIYQQ---QQQQKNVTN 1440
            .|:.:|:...:  |..::.|                 ||..:.:.:.|::.|.   ..:..::..
 Frog  1707 NSLSSSQDFSR--PSQVVST-----------------SNRTFLRNSSNSLPQSAAGPSKSASLPQ 1752

  Fly  1441 GSSINGNSSQGQEKVLSVSGKKKCSHCGDELGKLCYYVGCRGAAMIIESLLLFYHINCFKCCVCH 1505
            .|:::..|:|.:.|  ||||||.||:|.:.|||        |||||||||.|.:|::||||..|.
 Frog  1753 SSAVSQTSNQQRNK--SVSGKKLCSYCNNSLGK--------GAAMIIESLGLCFHLHCFKCVACE 1807

  Fly  1506 VQLGDGLNGTDVRVRNHKLHCQNCYSSDDGIKF 1538
            ..||...:|.:||:||.:|:|.:||     |||
 Frog  1808 TDLGGSESGAEVRIRNSELYCNSCY-----IKF 1835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smash	NP_001246912.1	DUF4757	<47..153	CDD:464950	22/77 (29%)
		PAT1	<1159..>1335	CDD:401645	30/187 (16%)
		LIM	<1494..1530	CDD:395333	15/35 (43%)
lmo7	XP_031752950.1	CH_SF	14..129	CDD:469584
		DUF4757	242..>314	CDD:464950
		DUF4757	700..837	CDD:464950	22/77 (29%)
		PDZ	1157..1225	CDD:214570	13/84 (15%)
		DUF5401	<1342..>1535	CDD:375164	46/297 (15%)
		LIM	1774..1831	CDD:214528	31/64 (48%)