DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smash and limch1

DIOPT Version :9

Sequence 1:NP_001246912.1 Gene:smash / 40583 FlyBaseID:FBgn0263346 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_004911274.2 Gene:limch1 / 100127553 XenbaseID:XB-GENE-5950305 Length:1924 Species:Xenopus tropicalis


Alignment Length:1872 Identity:360/1872 - (19%)
Similarity:621/1872 - (33%) Gaps:633/1872 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 KKLKEVKKEEP----------------EEWQNNLDNWKSSRRKRVEHIIDRAVETKKLELEEHDR 139
            ::|.:|:|::.                .::..|..|..|        .|...:..||.|.|::  
 Frog   240 RRLPDVRKDDMSARRVSYGENKAFVPFNQYLPNKSNQTS--------YIPAPLRKKKAEREDY-- 294

  Fly   140 LRRKSKTFTEMMEERAERGGPRGRAKLASLAVYNEDETNDLSDLGIGTSSASGKSSLSGDYDNNS 204
             |:...|.|..:      ||.|..:...|..:  ::|.|:|...|.||                 
 Frog   295 -RKSWSTATSPL------GGERPFSPKQSPVI--KEEQNELQCEGEGT----------------- 333

  Fly   205 VMSDHAAELDKAIGAASSVAAGVTAQNVDEQLNHINRNGSNGNHGNGAAVGQTG-----PSNSSK 264
                      |.:.|......|  |:|..|::          ....|..:||:.     |.::.:
 Frog   334 ----------KQMIALKEPCLG--AENRSERV----------GESEGGVMGQSSANDDIPKDAEE 376

  Fly   265 SAGRQYISSPG---------YDTSSSNAQ--ASSPDLC---EYT----YEGAIQD---------- 301
            ...|:::...|         |.:.|..|:  ..:||:.   |.|    |||...|          
 Frog   377 VRKRKHLQKAGIKVLPATKRYSSPSQFAEDIDGAPDIVLRKENTFLKSYEGMGSDSEEEEECKVP 441

  Fly   302 ----------------------YKQRVQRASSNGNGNANGKLIGEHIAYPTRRGSKIEDRLSGFE 344
                                  :.|.:|.:..|.| .|:.||.....:.|.  ..|:...:..::
 Frog   442 DIQRDDLATRRARMNQPKSPMQFNQYIQGSYLNKN-RASRKLNSSKTSTPA--SPKMSQDIREYQ 503

  Fly   345 ---------------VTSPSDTQEG--VEKQKV-DVPKVDISKRKEIFEQAKAEVSNGGAPAAPK 391
                           ...|||.:|.  .|::|| |:.|.|::|||     |||.||   .|..|.
 Frog   504 GPQLLKPSHVCKEKTFPIPSDNKEDAEAEQEKVPDIQKDDLAKRK-----AKASVS---LPKEPS 560

  Fly   392 LVFRDGLTNGNSATTAPKSEVRRLSGDISSIRDRMQSLEQQRKAFSSSKSVDVPVPPLKQRLNSL 456
            ......:|..:..|.   ..:|..|.|...:.||....::|......:::.:   ....:|..||
 Frog   561 AFAAVSITKADMETW---QRLRMSSEDSEHLNDRQADQQEQTSKIDVTRATN---DDFGRRKLSL 619

  Fly   457 QQSVAKEEQK----KPPLVALID--------------ARQLEIMRG-------------EEERMR 490
            |:..|:.:||    .|  |..||              .::.|.|:|             .....|
 Frog   620 QEKRARNKQKFVRFGP--VTEIDQQKWDRLCIAKAESGQESEEMKGSITSDETASHISPSASAQR 682

  Fly   491 QQQQKEKHS----PSQTTLCAPK----PAPP-----ALIIEE-------------PPVADTNDDS 529
            .|.|::..:    |.::....|:    ||||     ..::|.             ...|.|:.||
 Frog   683 SQPQEDVGTGPVLPHESRSFTPERLVSPAPPENESEIQLLETQQDDMMARRTGTFQKCARTSRDS 747

  Fly   530 GIQEDTADELQQQQQLNAAIAALALEERQ--------------LEEAANAVNQI----------- 569
            .:....|...||.::.:   .:|.|||:|              |.:.||..::.           
 Frog   748 PVSHQYALHSQQHEEKS---DSLELEEKQGLFLDVNPQLRKLLLSDLANTSSKATSPTLGSKSLK 809

  Fly   570 ---EAEFDELTDLHPSPL----PPSPALPAVQQSLQQPTVAQVPAQAVNQAAAPPLRDMEFSINE 627
               ||| |...|:....|    .|:..:|........|....:..:.::.:..|..    .|:..
 Frog   810 VTKEAE-DVKNDMKEGALNTGKDPNSVIPEDNTIAPDPEKDDMMTRKISVSQKPSC----VSLGH 869

  Fly   628 ALELALQAIDREATTKPMD-------KAQHPQKREQKE--ELGGKP-EEKEPICEEQHDEESNEQ 682
            .|.:......||...||..       |:::..|....:  ::..|| ::||   .::|.|..:..
 Frog   870 FLPVPFSLQRREGEKKPTSCIISSTKKSKNASKAVPADISDVPSKPLDQKE---TKEHGELGDTT 931

  Fly   683 GETHNEGGEMP--NKTDKQMQGGRE------------------PIYENVSSTISM---------- 717
            .:..:...|.|  .:.|.|.|.|.|                  |...|.|.||:.          
 Frog   932 CKQASNSVETPMCTELDSQQQDGLERRMILSTDLANTELKITPPTLANNSPTITKVQEPDATISE 996

  Fly   718 -------HEVDNEQIATMTITTQTQATRISHRRSIPSQQTSNSNENNQSTNQTSNSRNQKESSTA 775
                   .|.|:.....:::|.:.....:.|...:|. ......|..:||:.|.:.:.:.::.|.
 Frog   997 DNTTAPNPEKDDMMTRRISVTQKPSCVGLGHFLPVPF-SLQQKVEEKKSTSSTLSIKIKSDNCTQ 1060

  Fly   776 ATSAANPVPPTTPGEQAEPYYQVPKATEPYYDAPKHLRPVPVYENVEIFYSGLEISQG------- 833
            |.:..:...|.....|.|....|...::...|          ..:.||...|:...:|       
 Frog  1061 ALAVGSSDLPCKLLGQCETEGHVELRSDVTCD----------QTSTEIISDGIPTGKGLDTQAED 1115

  Fly   834 ---------------SV----GAPVGLMEPPKEKPPPPPTESPIPLDEGHDDELDGLGNSLGHNT 879
                           ||    |..:.:.:...|:     ..|..|....|.:.|..:.:.|....
 Frog  1116 ALETCDHELFRFSPRSVLSDDGESMSMCDMRYEE-----EGSMQPHSRAHYEHLQHVNSLLKEED 1175

  Fly   880 DTWSSDNTYETISNGTRRHLQGQPEPAQPSPPIKRMNSTKRIKKELRNKRSSFLGIENDGDLDD- 943
            |||..|    .....|||                |..|...||||.:.|:...: :..:.:|.: 
 Frog  1176 DTWQDD----LAKWKTRR----------------RSASQDLIKKEEQRKKMERM-MSGEDELSER 1219

  Fly   944 ---METYLELTVAPPPDMAQLLQEERRLEKQLYIKAGLCDSSDTGESRDSGVSENHSRQSSEHYT 1005
               ::||.|           :::|:.|.||:|:      ::....:|||          .:||..
 Frog  1220 RKSIKTYRE-----------IVEEKERREKELH------EAYKNAKSRD----------EAEHIL 1257

  Fly  1006 NSSEENDTQSEATPPPLPPPPSTAQVGEVIYQNES-----LLAAQTP-LLQTVKGNSAESWTESA 1064
            .|..|..|.|||....|..|       :::.:::|     |.:::.| :|:.::..|..|...::
 Frog  1258 QSYIEKFTISEAVLEGLVMP-------KILERSQSVEPSLLSSSEDPNILKYLRQQSLPSPKYTS 1315

  Fly  1065 TAAAAATQS------------------LSEATATANAKMQSIEDKIREQGEMLRVEREL-LHFSQ 1110
            |..|..:.|                  :|:......||..|.....:|..:..:|:.:: |:..:
 Frog  1316 TVEATVSPSSPCEAKSPTGLISPSKNIISKTVPMLTAKPYSQPKNTQEVLKTFKVDGKVNLNGVE 1380

  Fly  1111 EELKRQRENLVLRENIARRELQHGAKML---MSNNRRSLQDLHHGLGIGNGMLSAFQPP------ 1166
            |:.:.:..|.....::.|.::..|...:   :...::.:..:...|...| .|::.|.|      
 Frog  1381 EQKEEEHGNQTFAPSLTRSQMFEGVARVDVPVVEIKQDVTSIELNLARPN-TLNSLQEPKSLCED 1444

  Fly  1167 QHH---------QVQMPPPHPQQIYANVPQQQQQMVLHAYHQMDTDYRKSMSDLNEFSNCLILPP 1222
            ::|         .||:...|..:|.:               :.:|....:..|:...|: :.:||
 Frog  1445 RNHISQEDESDSLVQLERAHSVEILS---------------EGNTQSSNATQDVPVVSS-IEIPP 1493

  Fly  1223 -------TPPTKPLRAMQLNANGHGLEPDYAVSTRQRQPPAPYGGSLVKIAGAPMPPRLPGQGYP 1280
                   |...:.:.|.:|..: ..|||::..:......|.....:|.:               .
 Frog  1494 LTINGKDTVDERKVEAAELIMH-WSLEPNHKEAKENSLSPLKTSENLEE---------------S 1542

  Fly  1281 IQAPTAPAYHHQSAQNLSNMSRN---------------------TLLALSATP----------KP 1314
            :|.....: .|:...|::..|||                     .|:....:|          :.
 Frog  1543 LQFKENES-SHKVQLNITLQSRNAWRRSQFFLQPVDTECTENSPALVPSLNSPNRFCTWDPEEER 1606

  Fly  1315 KYADGWVQVQQR---KSYDSQQTS-DAAWLAAQ-----------QQKRKSMPD------------ 1352
            |..:.|.|.|:|   :.|..:|.. ...|..||           :::||.:.|            
 Frog  1607 KRQEKWQQEQERLLQERYQREQEKLKEEWEKAQKEVEEEERKYYEEERKIIEDTVVPLTLSPNSN 1671

  Fly  1353 -----------YGGAL--------YNNNHWLLQEAEQRRIEQLNRRSIPASKSMGKPLPDSIIQT 1398
                       :..||        .|||..||.|:.:....:.:..|....:.:......||:..
 Frog  1672 AQFNISERNGNFIPALTEHVKRDQENNNEKLLTESSRTIKNETHMHSNVTQQLLLHTQEGSILGA 1736

  Fly  1399 LTERVQSKG----------IGDRKRFDSNGNYSQVNGNNIYQQQQQQKNVTNG-SSING------ 1446
            ..::::.|.          |.||:...::...::.|.......|...|.||:. ||:.|      
 Frog  1737 KEKQIKGKTDKWEAEQSICIMDREELSNHVQSNECNTPTRLPLQAGCKQVTSSESSLPGDLGSPK 1801

  Fly  1447 ----------------------------NSSQG-----QEKVLSVSGKKKCSHCGDELGKLCYYV 1478
                                        ||||.     |....||||||.||.||..|||     
 Frog  1802 NPITEKDAIQNMSSIIPTRGTDFKEDTMNSSQSSTSQCQSPNRSVSGKKLCSTCGLPLGK----- 1861

  Fly  1479 GCRGAAMIIESLLLFYHINCFKCCVCHVQLGDGLNGTDVRVRNHKLHCQNCY 1530
               |||||||:|.|::||.||||.:|..||||.:.|||||:||..|:|.:||
 Frog  1862 ---GAAMIIETLSLYFHIQCFKCGLCKGQLGDAITGTDVRIRNGLLNCNDCY 1910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smashNP_001246912.1 DUF4757 14..152 CDD:292571 14/76 (18%)
LIM <1494..1530 CDD:278823 20/35 (57%)
limch1XP_004911274.2 CH_LIMCH1 23..140 CDD:409127
DUF4757 250..>313 CDD:406382 14/79 (18%)
DUF4757 <1125..1230 CDD:406382 27/141 (19%)
LIM 1852..1909 CDD:214528 36/64 (56%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007310
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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