DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spartin and spartb

DIOPT Version :9

Sequence 1:	NP_001246910.1	Gene:	spartin / 40582	FlyBaseID:	FBgn0037265	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001038916.1	Gene:	spartb / 751741	ZFINID:	ZDB-GENE-060825-146	Length:	269	Species:	Danio rerio

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	99/292 - (33%)	Gaps:	96/292 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 ECQQPGNAFGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSG 317
            ||...|       ..|.:....|:.|:..||....||.|:         |..||    ..:.|..
Zfish    26 ECINKG-------LNEDEAGHKEEALKLYQQGRQHLLRAI---------SVPSQ----GVECVGP 70

  Fly   318 SEQVSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKV- 381
            |.:.:|.:........||:             :|...|.:.|||      |:.|......|||:
Zfish    71 SWESARQMQHKMQETLSNI-------------TTRLAILETTPA------PNEVSNGTAAAQKLY 116

  Fly   382 --------THAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAM 438
                    .......|  |.|:|..||   |...:|.:|.  :.|.::...|....|    :|.:
Zfish   117 PEVPKVMPQRPTPPQT--INGRVAGAS---GGQTSPTVQP--NILCEQPPAYTPQAA----DGHL 170

  Fly   439 TIAAGAVEG----VSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVV 499
            ||:.|...|    |...|....:::...||||.|:         |::              :|.:
Zfish   171 TISYGTDSGELPVVGDEFYSQTSNSTPAGSSLGED---------GEE--------------LFFL 212

  Fly   500 SQNVN--YITPKGIAK--------KMVKRTGE 521
            .|.|.  ::||:|...        ::||.|.|
Zfish   213 PQGVQIFFVTPEGHVSAPSYPGYLRIVKFTSE 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spartin	NP_001246910.1	MIT_spastin	15..97	CDD:239142
spartin	NP_001246910.1	Senescence	325..511	CDD:284359	42/200 (21%)
spartb	NP_001038916.1	MIT_spastin	17..96	CDD:239142	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587262
Domainoid	1	1.000	105	1.000	Domainoid score	I6576
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4290
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290487at33208
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		otm24583
orthoMCL	1	0.900	-	-		OOG6_107088
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900