Protein Alignment spartin and Spart

DIOPT Version :9

• Sequence 1: NP_001246910.1
• Gene: spartin / 40582
• FlyBaseID: FBgn0037265
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006232427.2
• Gene: Spart / 295053
• RGDID: 1305900
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 146/663 - (22%)
• Similarity: 253/663 - (38%)
• Gaps: 191/663 - (28%)

  Fly    15 IRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACAL 79
            |:.||:.|...|:..::.:|.....:|...|:..:..:.....|....|......   |..|..:
  Rat    27 IKEAYEKAFMFVNKGLNTDELGQKEEAKTYYKQGIGHLLRGISIAAAEPGHTGPA---WEAARQM 88

  Fly    80 IQKLKSAETELRYRLKVLR-----SQKQSIDD----------------SAVEATEESRAEMDTKR 123
            .||:|.....:|.||::|.     |.:..:.|                |....:....||:|
  Rat    89 QQKMKETLQNVRTRLEILEKGLATSLRNDLQDVPKLYPEFPPKGTCKKSPEAESAPQHAEVD--- 150

  Fly   124 PPLLAENPSTQYGIANASG--------------------APKTYRELAA---------------- 152
                        |.|:|:|                    ||..|...||
  Rat   151 ------------GSASAAGAGPSAAPSALPLPSPGCPAEAPPAYTPQAAEGHYTVSYGTDSGEFS 203

  Fly   153 -------------------GLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLV 198
                               ||       ||..|:  |....|:::.:..:|.|:..|...
  Rat   204 SVGEDFYRNRSQPPPLETLGL-------DADELI--LIPNGVQIFFVNPAGEVSAPSYPG----- 254

  Fly   199 MCTVGGKWKYLSGIYFIQCSM-------PNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQ 256
                     ||..:.|:..|:       |.......|||||||..:...:...||::|||...|.
  Rat   255 ---------YLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTVGAYMFPDTMLQA 310

  Fly   257 PGNAFGLMLTKE------------------------GQTSRTEDELEDLQQFFL----------- 286
            .|...|::|:.|                        ......|:|.|:..:|.:
  Rat   311 AGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNREEEEEEEEEEDEFQIPGRVKELPKEA 375

  Fly   287 ---DLLEAVLAGTVV---------------QLKSPTSQRAGL-------------ASDTVSGSEQ 320
               |:.::..:|:.:               :.|..:|:...|             :.|....||:
  Rat   376 SGTDVRQSSSSGSSIDQGSKDARHKGKRGKKTKDSSSEEVNLRQIVPCEPSSEEKSKDLPEWSEK 440

  Fly   321 VSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAA 385
            |:.:|:|.|.:::..||:|||.||..:.:....:..::.|.....:|..:|...:.:|::.|..|
  Rat   441 VAHNILSGASWVSWGLVKGAEFTGKAIQKGASKLRERIQPEEKPVEVSPAVTRGLYIAKQATGGA 505

  Fly   386 AGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVST 450
            |.::.::...|.|.:..||:.||||:::.||||:.:....| .:..||::|||.:||.:|:|.||
  Rat   506 AKVSQFLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKRD-KDGKSTLDGAMVVAASSVQGFST 569

  Fly   451 VFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKM 515
            |:.|||.:||.:.:::|..:|:.:.:|||...|.......|:..||.|.:.|::.|..|.:.||.
  Rat   570 VWQGLECAAKCIVNNVSAETVQTVRYKYGHNAGEATHNAVDSAINVGVTAYNIDNIGIKAMVKKT 634

  Fly   516 VKRTGEAVVSDYK 528
            .|:||..::.||:
  Rat   635 AKQTGHTLLEDYQ 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spartin	NP_001246910.1	MIT_spastin	15..97	CDD:239142	18/81 (22%)
		Senescence	325..511	CDD:284359	60/185 (32%)
Spart	XP_006232427.2	MIT_spastin	27..106	CDD:239142	18/81 (22%)
		Senescence	445..629	CDD:399715	59/184 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346284
Domainoid	1	1.000	111	1.000	Domainoid score	I6120
eggNOG	1	0.900	-	-		E1_KOG2709
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290487at33208
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		oto96609
orthoMCL	1	0.900	-	-		OOG6_107088
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750