DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spartin and spart

DIOPT Version :9

Sequence 1:	NP_001246910.1	Gene:	spartin / 40582	FlyBaseID:	FBgn0037265	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_031751587.1	Gene:	spart / 100170472	XenbaseID:	XB-GENE-990805	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	143/605 - (23%)
Similarity:	251/605 - (41%)	Gaps:	112/605 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IRTAYKAAMTQVDLAVSHEE----QESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWND 75
            |...|:.|...::..:|.:|    :|:........|..:|      |:.:.|.....|..| |::
Frog    20 IEDEYRKAFKYINKGLSTDETGYKEEARNYYKQGQEHLIR------GLNISLQRPEFTGPA-WDN 77

  Fly    76 ACALIQKLKSAETELRYRLKVLRSQKQSIDDSAVEATEESRAEMDT-------------KRPP-- 125
            |..:..|::.....:..||.:|:....|:..::  |.|.:.::|..             :|||
Frog    78 ARQMQAKMEETLQNVNTRLNILQQSLTSLPSNS--AAENASSQMPALYPALPPKEKEKPERPPPP 140

  Fly   126 ---LLAENPSTQYGIANASGA--------------PKTYRELA------------AGLRELLAVR 161
               :....|....|.::...:              |..|...|            :|....:.|.
Frog   141 ISLVCPSEPCPVNGFSSVPSSETVQPIDPIMGAPTPPAYTPQATEGHYTVSYGTESGELSTVGVE 205

  Fly   162 ----------------DAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWKYLS 210
                            ||:.|:  |....|:::.:.|.|.||..|...              ||.
Frog   206 FYSMAAQPPPVQSLGVDAEELI--LIPQGVQIFFVTADGLVTAPSYPG--------------YLR 254

  Fly   211 GIYFIQCS---MPNEGTAGI----WLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLMLTKE 268
            .|.|:..:   ..|...|.:    |||||:.:.:...:|..|.::|||:..|.||:..|::|:.|
Frog   255 IIKFMDTNSEVAQNRPPAFLQVCDWLYPLMCTQSPVLRTNTGVYMFPDVMSQLPGSYVGVVLSSE 319

  Fly   269 ---GQTSRTEDELEDLQQFFLDLLEAV-----LAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHI 325
               ......||.|..:....:...||.     ::.||..:..|..:...|.    ..||:|::.|
Frog   320 LPIADQELFEDLLRQMSDLRIQPSEAASEVIDVSQTVHIITIPEEEEKELP----EWSEKVAQGI 380

  Fly   326 VSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTG 390
            :|.|.:|:..|.:|||.|...:.:....:...:.|.....:|..:|...:.||::.|..|..::.
Frog   381 LSGASWISWGLAKGAELTEKAIHKGASKLREHIQPEDKPLEVSPTVAKGLHVAKQATGGAVKVSQ 445

  Fly   391 WIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGL 455
            ::...|.:.:..|||.||||:::.|||||.:....| .:..|.::|||.:||..|:|.:||:.||
Frog   446 FLVDGVCSIASCVGRELAPHVKKHGSKLLPESLKKD-KDGKSPLDGAMAVAASGVQGFATVWQGL 509

  Fly   456 ETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTG 520
            |.:.|.:..|::..:|..|:||||:..|::......:..||...:.|::.|..|.:.||..|.|.
Frog   510 EFAGKNIAKSVASETVHTIKHKYGKDAGHVTDNAVHSAMNVGATAFNIDNIGIKALVKKTAKETS 574

  Fly   521 EAVVSDY---KRDLRKSESH 537
            .|::.:|   |:...|.|.|
Frog   575 HAILDEYKINKKQDEKEEKH 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spartin	NP_001246910.1	MIT_spastin	15..97	CDD:239142	17/85 (20%)
spartin	NP_001246910.1	Senescence	325..511	CDD:284359	57/185 (31%)
spart	XP_031751587.1	MIT_spastin	20..99	CDD:239142	17/85 (20%)
spart	XP_031751587.1	Senescence	380..564	CDD:399715	56/184 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6939
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290487at33208
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		oto103312
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3532
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050