DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and PSE1

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_014039.1	Gene:	PSE1 / 855356	SGDID:	S000004925	Length:	1089	Species:	Saccharomyces cerevisiae

Alignment Length:	1106	Identity:	351/1106 - (31%)
Similarity:	568/1106 - (51%)	Gaps:	105/1106 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QLLASLLSTDNDVRQQAEEAY-------NNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLF 67
            |::.:..|.||.:|..||:|.       ||:  |..:|.|.......|.:..| .::|||.|:|.
Yeast    14 QIVQAFASPDNQIRSVAEKALSEEWITENNI--EYLLTFLAEQAAFSQDTTVA-ALSAVLFRKLA 75

  Fly    68 TTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQ----------------LRRKICEVVAEVARN 116
            ..        .|..|:..::.:.:..:::||..|                :|.|:.:.:||..
Yeast    76 LK--------APPSSKLMIMSKNITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECV-- 130

  Fly   117 LIDEDCNNQWPDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAG 181
               :|....||::||.|.:...|..|..:||:.||.::||.:.   .|..|:.|..:........
Yeast   131 ---QDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLI---TAVDINSILPIFQSGFTDA 189

  Fly   182 SDPEVRVQAVRA-VGAFILYHDKENETAIHKHFADMLPRMIHITGETI-EAQDD--QSLLKLLIE 242
            || .|::.||.| ||.|     |:...:.......:||.:::.....: :.:||  .|:.:.|||
Yeast   190 SD-NVKIAAVTAFVGYF-----KQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIE 248

  Fly   243 MTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIP 307
            :.|..||..:...:.|.:....|..::|.|...|...||::...:||||.|. |....|...|:.
Yeast   249 LVELAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMC-KSNQNYGQTLVM 312

  Fly   308 LILHMMTD--LDDDE--NWSTADVVDDD-----DHSDNNVIAESSLDRLACGLGGKIVLPLVMNA 363
            :.|.|||:  :|||:  .|..:|..||:     ||      |..:|||:|..|||:.:...:...
Yeast   313 VTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDH------ARQALDRVALKLGGEYLAAPLFQY 371

  Fly   364 LPVMLGHADWKHRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMS 428
            |..|:...:|:.||||:||:|:..|||...:...:.:::..|:..::||||||:|..||.:||:|
Yeast   372 LQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQIS 436

  Fly   429 TDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETI 493
            |||:...::..|.:::|.|:|.|......|||.||.||||||||...|:||..|||.::..|..:
Yeast   437 TDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVL 501

  Fly   494 LNSKFKELVEKGNKL-VLEQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGK 557
            |.|         ||| |.||.:||||.:|:..:::|:.|||.|||.|..::: .|:.|..:|:||
Yeast   502 LQS---------NKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLK-VNNKDNSVLKGK 556

  Fly   558 TIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQ 622
            .:||.:|||.|||:|||...:.|::.:|:.  .:..::.:||...|||..:|:|:|:|||..|..
Yeast   557 CMECATLIGFAVGKEKFHEHSQELISILVA--LQNSDIDEDDALRSYLEQSWSRICRILGDDFVP 619

  Fly   623 YLPLVMGPVMRTATMKPEVAMLDNDEVEDIDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLV 687
            .||:|:.|::.||....:|.:::.:|..:.....||..:.: :.::.||.|:.:|||.||.|:|.
Yeast   620 LLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQV-QGKHIAIHTSVLDDKVSAMELLQ 683

  Fly   688 CYARELKEGFAEYAEDVVRQM-LPMLKFYFHDGVRTAAAESLPYLLDC-AKIKGPQ--YLEGMWM 748
            .||..|:..||.|.::|:.:: ||.|.||.|||||.|.|..:|.||.| ....|.|  .|..:|.
Yeast   684 SYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATGTQNEELVLLWH 748

  Fly   749 FICPELLKVIVTEPEPDVQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRL 813
            ....:|:..:::||.|::.....|||...|:.:|.|||:||.:....:.::..:.:.:||...|.
Yeast   749 KASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRH 813

  Fly   814 AARNEEDYDDGVEEELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRP 878
            .  :.::|::.::|   |:|.||..:|.:|.....|:.:|....:|...|.:.|.....|..:.|
Yeast   814 G--DGDEYNENIDE---EEDFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEP 873

  Fly   879 VADRQWGLCVFDDLIEFCGPACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAH 943
            :. ..:.|.|..|||::.|...|..:..|.|.:.:.:......:||||:|..||..|:|...:|.
Yeast   874 IL-VIFALVVIGDLIQYGGEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYAD 937

  Fly   944 TCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDS 1008
            .|...:..|||:::.|.::..||.|.||||.:|.||||...||.:.|||.....||..||...|.
Yeast   938 VCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIPNVDTYTANWFKTLPTITDK 1002

  Fly  1009 EEAAHIYGYLCDLIEGNHPVILGANNGNLPRIVSIIAESFCTKVVEA---QSATGTRMLTIVKQV 1070
            |.|:..|.:|..|||.|.|::...:|      :|.:.:|    |::|   :|.|.....|::..|
Yeast  1003 EAASFNYQFLSQLIENNSPIVCAQSN------ISAVVDS----VIQALNERSLTEREGQTVISSV 1057

  Fly  1071 E 1071
            :
Yeast  1058 K 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	10/27 (37%)
		HEAT repeat	165..216	CDD:293787	12/51 (24%)
		HEAT repeat	235..261	CDD:293787	8/25 (32%)
		HEAT repeat	272..305	CDD:293787	11/32 (34%)
		HEAT repeat	357..385	CDD:293787	9/27 (33%)
		HEAT_2	364..467	CDD:290374	40/102 (39%)
		HEAT_EZ	373..427	CDD:290247	22/53 (42%)
		HEAT repeat	401..429	CDD:293787	12/27 (44%)
		ARM	405..503	CDD:237987	43/97 (44%)
		HEAT repeat	442..473	CDD:293787	16/30 (53%)
		HEAT repeat	485..519	CDD:293787	12/34 (35%)
		HEAT repeat	532..565	CDD:293787	13/32 (41%)
		HEAT repeat	867..894	CDD:293787	7/26 (27%)
		HEAT repeat	906..936	CDD:293787	9/29 (31%)
		HEAT repeat	947..979	CDD:293787	12/31 (39%)
PSE1	NP_014039.1	HEAT repeat	106..128	CDD:293787	2/21 (10%)
		HEAT repeat	140..168	CDD:293787	10/27 (37%)
		HEAT repeat	177..207	CDD:293787	10/35 (29%)
		HEAT repeat	222..248	CDD:293787	4/25 (16%)
		HEAT repeat	261..292	CDD:293787	7/30 (23%)
		Importin_rep_4	274..365	CDD:408579	34/97 (35%)
		HEAT repeat	368..396	CDD:293787	10/27 (37%)
		HEAT_EZ	<396..435	CDD:404407	14/38 (37%)
		HEAT_2	<403..475	CDD:404525	27/71 (38%)
		HEAT repeat	408..438	CDD:293787	13/29 (45%)
		HEAT repeat	450..477	CDD:293787	12/26 (46%)
		HEAT repeat	491..520	CDD:293787	15/37 (41%)
		Importin_rep_6	766..868	CDD:408599	26/106 (25%)
		Importin_rep_5	1001..1054	CDD:408587	18/62 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343813
Domainoid	1	1.000	223	1.000	Domainoid score	I444
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1710
Inparanoid	1	1.050	498	1.000	Inparanoid score	I212
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	1	1.010	-	-		QHG53802
OrthoFinder	1	1.000	-	-		FOG0003156
OrthoInspector	1	1.000	-	-		oto100154
orthoMCL	1	0.900	-	-		OOG6_101397
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R602
SonicParanoid	1	1.000	-	-		X2119
TreeFam	1	0.960	-	-
	16	15.740