DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and IPO4

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_078934.3	Gene:	IPO4 / 79711	HGNCID:	19426	Length:	1081	Species:	Homo sapiens

Alignment Length:	1167	Identity:	264/1167 - (22%)
Similarity:	466/1167 - (39%)	Gaps:	170/1167 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLFT 68
            :.|..:|||..||..|.:..::|.|....:.|.......|.::.......:.||.||||.||...
Human     2 ESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRLN 66

  Fly    69 TEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQFL 133
            |.    ::.|.||.:..|...||.|:|:|....:...:.::.|.:.|    ::....||.:||.|
Human    67 TR----WRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFR----KEGLEAWPQLLQLL 123

  Fly   134 FQCANSPTPQLQESALRIFSSV----PSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAV 194
            ....:||....:|..|.:.|.|    |..|.....:.:.|:.:.|.   :.|| |.:...::|.:
Human   124 QHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLG---EVGS-PGLLFYSLRTL 184

  Fly   195 GAFILYHDKENETAIHKHFADML-PRMIHITGETIEAQDDQ---SLLKLLIEMTENCPKFLRPQL 255
            .....|...|:..     .|.|| |::| :..:|:...|:.   ..|:.|.|:.|:....:.|.|
Human   185 TTMAPYLSTEDVP-----LARMLVPKLI-MAMQTLIPIDEAKACEALEALDELLESEVPVITPYL 243

  Fly   256 EFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE-NAPSMIRKRADKYIVALIPLILHMM------ 313
            ..:...|::|..:....::.|..:|..:..|.: .:.::::.|       |:|.:||.:
Human   244 SEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNR-------LLPPLLHTLFPIVAA 301

  Fly   314 ---------TDLDDDENWSTADVVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLG 369
                     .|.|.:|.....:::.:....    .|...:|.||..|..:.:.|.:|..|...|.
Human   302 EPPPGQLDPEDQDSEEEELEIELMGETPKH----FAVQVVDMLALHLPPEKLCPQLMPMLEEALR 362

  Fly   370 HADWKHRFAALMAISAIGEGCHKQM-EAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQ 433
            ......|.|.|:.::.:.:|....: :.:|..::..|...|.||...||.||..|:||.|.:. |
Human   363 SESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENL-Q 426

  Fly   434 TFEKKFHSQVIPGLLSLLDDVENPRVQAH----AGAALVNFSEDC-PKNILTRYLDGIMAKLETI 493
            .....:..:|:|.||:.|..|  |....|    |..||.||.|:. ||  :..||..:|..:..:
Human   427 PHISSYSREVMPLLLAYLKSV--PLGHTHHLAKACYALENFVENLGPK--VQPYLPELMECMLQL 487

  Fly   494 LNS----KFKELVEKGNKLVLEQVVTTIASVADTCESEFVAYYDRLMPCLK-FIIQNANSDDLRM 553
            |.:    :.|||           .|:.:.::|...::..:.|:..:|..|: |::  ...:||:.
Human   488 LRNPSSPRAKEL-----------AVSALGAIATAAQASLLPYFPAIMEHLREFLL--TGREDLQP 539

  Fly   554 LRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGGELAD--DDP---QTSYLITAWARMC 613
            ::.:::|.:.::..||| |.....|.|...:       |..|.|  |||   :.:|  :.:|.:.
Human   540 VQIQSLETLGVLARAVG-EPMRPLAEECCQL-------GLGLCDQVDDPDLRRCTY--SLFAALS 594

  Fly   614 KILGK----QFEQYLPLVMGPVMRTATMKP-------------------EVAMLDNDEVEDIDGD 655
            .::|:    ..||...|::..:..|..:.|                   |..::|.|..|:.|.:
Human   595 GLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSE 659

  Fly   656 VDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYFHDGV 720
            :          ..:::..|..|:|...|..:...:......|..|.|.|..::..:|:.. |..|
Human   660 I----------SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECP-HLNV 713

  Fly   721 RTAAAESLPYLLDCAKIKGPQ---------YLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAK 776
            |.||.|:|.... ||..|..|         .|:.....:.|..::.:..|.|..|...:|.:|..
Human   714 RKAAHEALGQFC-CALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTG 777

  Fly   777 CIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILS 841
            .:.:.|...|........|..:.|.||:      ::.|.   :|.|:..|||..:|.:.|..:|.
Human   778 VLRSCGTLTLKPPGRLAELCGVLKAVLQ------RKTAC---QDTDEEEEEEDDDQAEYDAMLLE 833

  Fly   842 KIVDITHAL-FQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQ 905
            ...:...|| .......|.|.|....|..|...:....||::.:.:....:.|:..|.|.|.:..
Human   834 HAGEAIPALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVS 898

  Fly   906 IFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAG----EQFAHTCAQIIPLLVQVINDPKAREIEN 966
            ...|.|:....:..||||..|.:|.|||.:..|    |.|......:.|||.:..:| :.|
Human   899 RLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHD-RVR---- 958

  Fly   967 ISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILG 1031
                :|...|.|::|..:.:.... .:::......||:.||.||...| |.|...:..:.|..:.
Human   959 ----DNICGALARLLMASPTRKPE-PQVLAALLHALPLKEDLEEWVTI-GRLFSFLYQSSPDQVI 1017

  Fly  1032 ANNGNLPRIVSIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQ 1093
            .....|.||.|:|...  .|:.....|....:||.:  .:.:.:...|...:|..::.|.||
Human  1018 DVAPELLRICSLILAD--NKIPPDTKAALLLLLTFL--AKQHTDSFQAALGSLPVDKAQELQ 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	9/31 (29%)
		HEAT repeat	165..216	CDD:293787	9/50 (18%)
		HEAT repeat	235..261	CDD:293787	6/25 (24%)
		HEAT repeat	272..305	CDD:293787	4/33 (12%)
		HEAT repeat	357..385	CDD:293787	7/27 (26%)
		HEAT_2	364..467	CDD:290374	29/107 (27%)
		HEAT_EZ	373..427	CDD:290247	15/54 (28%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		ARM	405..503	CDD:237987	36/106 (34%)
		HEAT repeat	442..473	CDD:293787	13/34 (38%)
		HEAT repeat	485..519	CDD:293787	6/37 (16%)
		HEAT repeat	532..565	CDD:293787	6/33 (18%)
		HEAT repeat	867..894	CDD:293787	4/26 (15%)
		HEAT repeat	906..936	CDD:293787	11/29 (38%)
		HEAT repeat	947..979	CDD:293787	7/31 (23%)
IPO4	NP_078934.3	IBN_N	24..90	CDD:197981	20/69 (29%)
		HEAT 1	348..385		8/36 (22%)
		HEAT repeat	353..381	CDD:293787	6/27 (22%)
		ARM	355..467	CDD:237987	33/114 (29%)
		HEAT 2	390..427		13/37 (35%)
		HEAT_2	392..505	CDD:290374	38/128 (30%)
		HEAT repeat	394..424	CDD:293787	12/29 (41%)
		HEAT 3	431..471		14/41 (34%)
		HEAT repeat	435..464	CDD:293787	11/30 (37%)
		HEAT 4	475..513		9/48 (19%)
		HEAT repeat	477..507	CDD:293787	7/40 (18%)
		HEAT repeat	519..551	CDD:293787	6/33 (18%)
		HEAT 5	895..932		11/36 (31%)
		HEAT 6	936..974		11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810