DRSC/TRiP Functional Genomics Resources

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Protein Alignment Karybeta3 and Ipo5

DIOPT Version :9

Sequence 1:NP_001262259.1 Gene:Karybeta3 / 40581 FlyBaseID:FBgn0087013 Length:1105 Species:Drosophila melanogaster
Sequence 2:NP_076068.1 Gene:Ipo5 / 70572 MGIID:1917822 Length:1097 Species:Mus musculus


Alignment Length:1102 Identity:579/1102 - (52%)
Similarity:791/1102 - (71%) Gaps:9/1102 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRL 66
            ||:|..|..||.:|||.||.||:||||.|.|:....|:|.||..|:|...:||||||||||||||
Mouse     5 AAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGRSKITFLLQAIRNTTAAEEARQMAAVLLRRL 69

  Fly    67 FTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQ 131
            .::.|.:.|..||::.|..:..::|:.:|.|....:|:|||::.||:||||||||.|||||:.|:
Mouse    70 LSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKICDIAAELARNLIDEDGNNQWPEGLK 134

  Fly   132 FLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGA 196
            |||...:|....|:|:||.||.:.|.|||||:..|:|:||:||.:.|.....|.:|..:.||..|
Mouse   135 FLFDSVSSQNMGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAA 199

  Fly   197 FILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEV 261
            |||.:  |:..|:.|||||:||..:....::. .|:|.|:||.|:|:.:..||:|||.||...::
Mouse   200 FILAN--EHNVALFKHFADLLPGFLQAVNDSC-YQNDDSVLKSLVEIADTVPKYLRPHLEATLQL 261

  Fly   262 CMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTAD 326
            .:|:....:..:..|.|.|||:|:|:|.|.:|:||.. ..|...||.:|.||.||::||:|:.||
Mouse   262 SLKLCGDTNLNNMQRQLALEVIVTLSETAAAMLRKHT-SLIAQTIPQMLAMMVDLEEDEDWANAD 325

  Fly   327 VVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCH 391
            .::|||...|.|..||:|||:|||||||:|||::...:..||.:.|||:|.|.|||:||||||||
Mouse   326 ELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCH 390

  Fly   392 KQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVEN 456
            :|||.||:|:::.||.||.|||||||||||||:|||:||||..|:||||.:||..||..::|..|
Mouse   391 QQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGN 455

  Fly   457 PRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVA 521
            .||||||.|||:||:|||||::|..|||.::..|.:|:..|.:||::||.|||||||||:|||||
Mouse   456 QRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVA 520

  Fly   522 DTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLL 586
            ||.|.:||.|||..||.||.|::||...:||:||||||||:||||||||:|||:.||.:||.:||
Mouse   521 DTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLL 585

  Fly   587 VNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVED 651
            ...|:..::.|||||.||:|:|||||||||||:|:||||:||||:|:||::|||||:||..::|:
Mouse   586 KTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMEN 650

  Fly   652 IDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYF 716
            :..|..|.|:|||:||:|.|:|||:::|::||:||||||:||||||.||.|.||:.|:|:|||||
Mouse   651 MSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYF 715

  Fly   717 HDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETL 781
            |||||.|||||:|.||:||:::||:||..||.|:|..|:|.|.|||:.||.||:::|.|||||.:
Mouse   716 HDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM 780

  Fly   782 GPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDI 846
            |..|||.:..:::..|:...:.|||:..:.|...|.:||||:.|||.|.::||.|||||:|:.||
Mouse   781 GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDI 845

  Fly   847 THALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPAL 911
            .|::|.:.|.:.||.|||:.|..|.|:.|.||..|||||||:|||::|.|.||...|.:.|...:
Mouse   846 LHSIFSSYKEKVLPWFEQLLPLIVNLICPQRPWPDRQWGLCIFDDIVEHCSPASFKYAEYFISPM 910

  Fly   912 VQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISA 976
            :|||||.:||||||||||.||:.||.|:.:...|...:||||:||..|:|:..||::.|||.|||
Mouse   911 LQYVCDNSPEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENVNATENCISA 975

  Fly   977 FAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIV 1041
            ..||:|:....: ||:|::..|.||||:.||.|||...:.|||||||.|||::||.||.|||:|.
Mouse   976 VGKIMKFKPDCV-NVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNHPIVLGPNNTNLPKIF 1039

  Fly  1042 SIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103
            |||||....:.::.:.....|:..:|:||:::..:...|.:.||||||.|:|    ||.|.|
Mouse  1040 SIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQ----ELLNSA 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Karybeta3NP_001262259.1 HEAT repeat 129..157 CDD:293787 11/27 (41%)
HEAT repeat 165..216 CDD:293787 21/50 (42%)
HEAT repeat 235..261 CDD:293787 12/25 (48%)
HEAT repeat 272..305 CDD:293787 13/32 (41%)
HEAT repeat 357..385 CDD:293787 12/27 (44%)
HEAT_2 364..467 CDD:290374 66/102 (65%)
HEAT_EZ 373..427 CDD:290247 39/53 (74%)
HEAT repeat 401..429 CDD:293787 20/27 (74%)
ARM 405..503 CDD:237987 60/97 (62%)
HEAT repeat 442..473 CDD:293787 17/30 (57%)
HEAT repeat 485..519 CDD:293787 17/33 (52%)
HEAT repeat 532..565 CDD:293787 20/32 (63%)
HEAT repeat 867..894 CDD:293787 16/26 (62%)
HEAT repeat 906..936 CDD:293787 18/29 (62%)
HEAT repeat 947..979 CDD:293787 16/31 (52%)
Ipo5NP_076068.1 HEAT 1. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 5..38 19/32 (59%)
KAP95 13..>634 CDD:227540 335/624 (54%)
HEAT 2. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 43..77 20/33 (61%)
HEAT 3. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 95..122 12/26 (46%)
HEAT 4. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 130..157 12/26 (46%)
HEAT 5. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 167..201 12/33 (36%)
HEAT repeat 177..199 CDD:293787 6/21 (29%)
HEAT 6. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 210..246 14/36 (39%)
HEAT repeat 217..245 CDD:293787 9/28 (32%)
HEAT 7. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 254..289 10/34 (29%)
HEAT repeat 257..289 CDD:293787 8/31 (26%)
Importin_rep_4 268..357 CDD:408579 43/89 (48%)
HEAT 8. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 298..350 25/52 (48%)
Ran-GTP binding. /evidence=ECO:0000250 325..375 26/49 (53%)
HEAT 9. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 352..386 17/33 (52%)
HEAT repeat 355..387 CDD:293787 16/31 (52%)
HEAT 10. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 390..430 28/39 (72%)
HEAT repeat 399..429 CDD:293787 21/29 (72%)
HEAT 11. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 432..472 22/39 (56%)
HEAT repeat 441..468 CDD:293787 15/26 (58%)
HEAT 12. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 475..523 27/47 (57%)
HEAT repeat 482..519 CDD:293787 20/36 (56%)
HEAT 13. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 525..568 27/42 (64%)
HEAT repeat 531..564 CDD:293787 20/32 (63%)
HEAT 14. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 570..615 25/44 (57%)
HEAT 15. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 617..692 43/74 (58%)
HEAT 16. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 695..737 29/41 (71%)
HEAT 17. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 741..780 22/38 (58%)
Importin_rep_6 765..874 CDD:408599 48/108 (44%)
HEAT 18. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 787..853 26/65 (40%)
HEAT 19. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 856..895 22/38 (58%)
HEAT repeat 865..890 CDD:293787 14/24 (58%)
HEAT 20. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 903..935 18/31 (58%)
HEAT repeat 906..934 CDD:293787 18/27 (67%)
HEAT_EZ 921..966 CDD:404407 23/44 (52%)
HEAT 21. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 943..983 20/39 (51%)
HEAT repeat 946..982 CDD:293787 18/35 (51%)
HEAT 22. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 990..1021 16/30 (53%)
HEAT repeat 991..1015 CDD:293787 11/23 (48%)
Importin_rep_5 1005..1051 CDD:408587 27/45 (60%)
HEAT 23. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 1032..1067 12/34 (35%)
HEAT 24. /evidence=ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588 1070..1093 9/26 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831286
Domainoid 1 1.000 410 1.000 Domainoid score I693
eggNOG 1 0.900 - - E1_KOG2171
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1710
Inparanoid 1 1.050 1189 1.000 Inparanoid score I194
Isobase 1 0.950 - 0 Normalized mean entropy S1555
OMA 1 1.010 - - QHG53802
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003156
OrthoInspector 1 1.000 - - otm44074
orthoMCL 1 0.900 - - OOG6_101397
Panther 1 1.100 - - LDO PTHR10527
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R602
SonicParanoid 1 1.000 - - X2119
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

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