DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and Apl

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_730182.1	Gene:	Apl / 59216	FlyBaseID:	FBgn0042178	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1193	Identity:	250/1193 - (20%)
Similarity:	500/1193 - (41%)	Gaps:	232/1193 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QAHFQQLLASLLSTDND-VRQQAE---EAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRR 65
            :|....::..:|:.|.: :|:...   :||.|....|.:|.::.:.:..|:    ||:|||||:|
  Fly     2 EAAILDIINGILTIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQE----RQVAAVLLKR 62

  Fly    66 LFTTEFFDFYKGLPAESQNQL---LQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQW- 126
              ..:....::.:|||.|..:   :.|:|:||:::.   ::..:..::..:.|:  :|...|.|
  Fly    63 --RVKKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKT---VKGTVAFIIGSLVRH--EEGEQNSWR 120

  Fly   127 PDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLA---------------- 175
            .:||:|:::..:||.|...|....||||:.....:|.:.:.|.:..:||
  Fly   121 EEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANGNMATPT 185

  Fly   176 -KSMDAGS------------DPEVRVQAV----RAVGAFILYHDKENETAIHKHFADMLPRMIHI 223
             .:|..||            ..::.|:||    :|:.||:   :|
  Fly   186 VHNMLTGSCFLLPFVSGHSNAEQIVVKAVPLILKALAAFV---EK-------------------- 227

  Fly   224 TGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE 288
             |.:||.   .....::..|.|:.|..|...::.:.|.|:.:..::.|:.|.|..||..:.||..
  Fly   228 -GYSIEF---MGAFDIIDSMAEHVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVR 288

  Fly   289 NAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTADVVDDDDH-------SDNNVIAESSLDR 346
            ....:|.|:  |.:...:.::..::...|.:|.        |||:       |.:|..|: :||.
  Fly   289 LKKKIIMKQ--KLLQPTLSVLFEVICQDDLEEG--------DDDYFSSESLSSPSNAAAQ-TLDL 342

  Fly   347 LACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC-----HKQMEAILDEVMSGVL 406
            :|..:.....:|.:::.|...|...:...|.::.:.:..|.|||     .|.:|.:|:.:.:|||
  Fly   343 MALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL 407

  Fly   407 NFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGA------ 465
                |....||.||..|:||.| :|.|....||..|::|.|...|:.:.   ::...|.
  Fly   408 ----DSVMFVRTAAFFALGQFS-EFLQPTICKFAPQILPVLFDYLNQLV---LELKVGEPDSKHM 464

  Fly   466 -----ALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCE 525
                 ||..|.|:..::|:. ||..:|.:|       |..:..:.:..:.|..::.||:|:...:
  Fly   465 DRMFYALETFCENLDEDIVP-YLPTLMDRL-------FGVMEPQNSNQMREMALSAIAAVSAAAK 521

  Fly   526 SEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHT 590
            ...:.|:.|:|..|:..:......::...|.:.|:.::.:...:|::..|..|.:.|:..|:...
  Fly   522 ENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADDTMNFCLMMLE 586

  Fly   591 EGGELADDDPQTSYLITAWARMCKI-------LGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDE 648
            :|    .|||:  |..:.:..|..:       :...|.:::..:|..|:.:..|.|.|:...:|:
  Fly   587 DG----PDDPE--YRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMVPNVSDNADDD 645

  Fly   649 VEDIDG-DVDWSFINL------GEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVR 706
            :..:|. |::   |:|      .:|..:.:....:.:|..|...|..:|......||.|.:....
  Fly   646 LALVDAPDIE---IDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFE 707

  Fly   707 QMLPMLKFYFHDGVRTAAAESL-PYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSEL 770
            .:..|:.....| ||.|..:|: .::....|:.....|:.......|:...::.|:.:..|...:
  Fly   708 NVYKMIDHPQGD-VRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRM 771

  Fly   771 LNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFER---------ADKRLAARNEEDYDDGVE 826
            |:.|             .|..|.|..|.::   ||.|.         .:|.....|||  ..|.:
  Fly   772 LDVL-------------YDVFKYVPAINSQ---EHAELIFGCIRDIFTNKMACQFNEE--SGGGD 818

  Fly   827 EELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAF------EQVAPHFVKL----LEPSRPVAD 881
            :|.:|:.:.|           ..||: |.|...|.|      |..:.:|.:|    ::....|.:
  Fly   819 DECSEESEND-----------EMLFE-NAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKE 871

  Fly   882 R---QWGLCVFDDLIEFCGP---ACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQ 940
            |   :....::..|.:.|..   .||.|.....|..:....|...:.||.:.:..|.: .|..|:
  Fly   872 RDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEI-VFHSEE 935

  Fly   941 FAHTCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVS 1005
            .:.   :..|.::|.:::...|| ...:..:|...|.|:::..|..::. :.:::.||.:.||:.
  Fly   936 KSF---ESYPTILQALSEAIVRE-SVPAAMDNICGAVARLIVTNPDSVP-LGQVLPVWLNHLPLK 995

  Fly  1006 EDSEEAAHIYGYLCDLIEGNHPVI-LGAN---NGNLPRIVSIIAE-SFCTKVVEAQSATGTRMLT 1065
            :|:.|.        |:|:....|: |.|.   ..:|.:|::|..| |:..::.:.:  |....:.
  Fly   996 DDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKRQMPDVE--TTESAVA 1050

  Fly  1066 IVKQVESN-PEVMAACASTLSPE 1087
            ::|::.:| ||:.:. .|.::||
  Fly  1051 LIKEIRANYPELFSK-VSNMNPE 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	13/83 (16%)
		HEAT repeat	235..261	CDD:293787	4/25 (16%)
		HEAT repeat	272..305	CDD:293787	9/32 (28%)
		HEAT repeat	357..385	CDD:293787	4/27 (15%)
		HEAT_2	364..467	CDD:290374	31/118 (26%)
		HEAT_EZ	373..427	CDD:290247	18/58 (31%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		ARM	405..503	CDD:237987	30/108 (28%)
		HEAT repeat	442..473	CDD:293787	8/41 (20%)
		HEAT repeat	485..519	CDD:293787	5/33 (15%)
		HEAT repeat	532..565	CDD:293787	5/32 (16%)
		HEAT repeat	867..894	CDD:293787	5/33 (15%)
		HEAT repeat	906..936	CDD:293787	5/29 (17%)
		HEAT repeat	947..979	CDD:293787	6/31 (19%)
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	19/66 (29%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	13/34 (38%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840