Protein Alignment Karybeta3 and Arts

DIOPT Version :10

• Sequence 1: NP_524226.1
• Gene: Karybeta3 / 40581
• FlyBaseID: FBgn0087013
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1195
• Identity: 259/1195 - (21%)
• Similarity: 501/1195 - (41%)
• Gaps: 236/1195 - (19%)

  Fly     5 QAHFQQLLASLLSTDND-VRQQAE---EAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRR 65
            :|....::..:|:.|.: :|:...   :||.|....|.:|.::.:.:..|:    ||:|||||:|
  Fly     2 EAAILDIINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQE----RQVAAVLLKR 62

  Fly    66 LFTTEFFDFYKGLPAESQNQL---LQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQW- 126
              ..:....::.:|||.|..:   :.|:|:||:::.   ::..:..::..:.|:  :||..|.|
  Fly    63 --RVKKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKT---VKGTVAFIIGSLVRH--EEDKQNSWR 120

  Fly   127 PDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLA---------------- 175
            .:||:|:::..:||.|...|....||||:.....:|.:.:.|.|..:||
  Fly   121 EEILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPT 185

  Fly   176 -KSMDAG-----------SDPE-VRVQAV----RAVGAFILYHDKENETAIHKHFADMLPRMIHI 223
             .:|.||           ||.| :.|:||    :|:.||.   :|.|
  Fly   186 VHNMLAGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFA---EKGN------------------ 229

  Fly   224 TGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE 288
            :.|.:.|.|      ::..|.|..|..|...::.:.|.|:.:..::.|:.|.|..||..:.||..
  Fly   230 SNEFMGAFD------IIDSMAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVR 288

  Fly   289 NAPSMIRKRADKYIVALIPLILHMMTDLD----DDENWSTADVVDDDDHSDNNVIAESSLDRLAC 349
            ....:|.|:  |.:...:.::..::...|    ||:.:|:..:     :|.:|..|: :||.:|.
  Fly   289 LKKKIIMKQ--KLLQPTLSVLFEVICQDDLKEGDDDYFSSESL-----NSPSNAAAQ-TLDLMAL 345

  Fly   350 GLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC-----HKQMEAILDEVMSGVLNFL 409
            .:.....:|.:::.|...|...:...|.::.:.:..|.|||     .|.:|.:|:.:.:|||
  Fly   346 HMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL--- 407

  Fly   410 SDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGA--------- 465
             |....||.||..|:||.| :|.|....||..|::|.|...|:.:.   ::...|.
  Fly   408 -DSVMFVRTAAFFALGQFS-EFLQPTICKFAPQILPVLFDYLNQLV---LELKVGEPDSKHMDRM 467

  Fly   466 --ALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCESEF 528
              ||..|.|:..::|:. ||..:|.:|       |..:..:.:..:.|..::.||:|:...:...
  Fly   468 FYALETFCENLDEDIVP-YLPTLMDRL-------FGVMEPQNSNQMREMALSAIAAVSAAAKENL 524

  Fly   529 VAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGG 593
            :.|:.|:|..|:..:......::...|.:.|:.::.:...:|::..|..|.|.|:..|:...:|
  Fly   525 MPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDG- 588

  Fly   594 ELADDDPQ-TSYLITAWARMCKILGKQ----FEQYLPLVMGPVMRTATMKPEV--------AMLD 645
               .|||: ...:....:.:..::.:.    |.:::..:|..|:.:..|.|.|        |::|
  Fly   589 ---PDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVD 650

  Fly   646 NDEVE-DID--GDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQ 707
            ..::| |::  .|.|.....|||.....       :|..|...|..:|......||.|.:.....
  Fly   651 APDIEIDLEHTDDEDDQDAYLGENDYIV-------EKEEAILSLKEFATHTGAAFAPYLQSAFEN 708

  Fly   708 MLPMLKFYFHDGVRTAAAESL-PYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELL 771
            :..|:.....| ||.|..:|: .::....|:.....|:.......|:...::.|:.:..|...:|
  Fly   709 VYKMIDHPQGD-VRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRML 772

  Fly   772 NSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFER---------ADKRLAARNEEDYDDGVEE 827
            :.|             .|..|.|..|.::   ||.|.         .:|.....|||  ..|.::
  Fly   773 DVL-------------YDVFKYVPAINSQ---EHAELIFGCIRDIFTNKMACQFNEE--SGGGDD 819

  Fly   828 ELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAF------EQVAPHFVKL----LEPSRPVADR 882
            |.:|:.:.|           ..||: |.|...|.|      |..:.:|.:|    ::....|.:|
  Fly   820 ECSEESEND-----------EMLFE-NAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKER 872

  Fly   883 ---QWGLCVFDDLIEFCGP---ACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQF 941
               :....::..|.:.|..   .||.|.....|..:....|...:.||.:.:..|.: .|..|:.
  Fly   873 DLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEI-VFHSEEK 936

  Fly   942 AHTCAQIIPLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSE 1006
            :.   :..|.::|.:::...|| ...:..:|...|.|:::..|..::. :.:::.||.:.||:.:
  Fly   937 SF---ESYPTILQALSEAIVRE-SVPAAMDNICGAVARLIVTNPDSVP-LGQVLPVWLNHLPLKD 996

  Fly  1007 DSEEAAHIYGYLCDLIEGNHPVI-LGAN---NGNLPRIVSIIAESFCTK----VVEAQSATGTRM 1063
            |:.|.        |:|:....|: |.|.   ..:|.:|::|..|:...|    |...:||
  Fly   997 DTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESA----- 1048

  Fly  1064 LTIVKQVESN-PEVMAACASTLSPE 1087
            :.::|::.:| ||:.:. .|.::||
  Fly  1049 VALIKEIRANYPELFSK-VSNMNPE 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_524226.1	KAP95	6..>625	CDD:227540	153/684 (22%)
		HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	18/83 (22%)
		HEAT repeat	235..261	CDD:293787	4/25 (16%)
		Importin_rep_4	268..358	CDD:408579	20/93 (22%)
		HEAT repeat	272..305	CDD:293787	9/32 (28%)
		HEAT repeat	357..385	CDD:293787	4/27 (15%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		HEAT repeat	442..473	CDD:293787	8/41 (20%)
		HEAT repeat	485..519	CDD:293787	5/33 (15%)
		HEAT repeat	532..565	CDD:293787	5/32 (16%)
		Importin_rep_6	766..875	CDD:465881	27/127 (21%)
		HEAT repeat	867..894	CDD:293787	5/33 (15%)
		HEAT repeat	906..936	CDD:293787	5/29 (17%)
		HEAT repeat	947..979	CDD:293787	6/31 (19%)
		Importin_rep_5	1007..1059	CDD:465877	14/59 (24%)
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/66 (29%)
		KAP95	<304..703	CDD:227540	94/431 (22%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	13/34 (38%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)