DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and kpnb3

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_009303669.1	Gene:	kpnb3 / 569455	ZFINID:	ZDB-GENE-030424-2	Length:	1093	Species:	Danio rerio

Alignment Length:	1102	Identity:	568/1102 - (51%)
Similarity:	790/1102 - (71%)	Gaps:	11/1102 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLF 67
            |:|..|..||::|:|.||.||:|:||||:.:..:.|:|.||..|::...:||.:||||||||||.
Zfish     2 AEQQQFYLLLSNLMSPDNTVRKQSEEAYDTIPGQTKITFLLQAIRDASAAEEVKQMAAVLLRRLL 66

  Fly    68 TTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQF 132
            ::.|.:.|..|..:.|..:..::|..::.|.:..:|:|.|::.||:||||||:|.|||||:||:|
Zfish    67 SSSFEEVYPNLTVDIQTAIKTELLAGIRSEASTNIRKKTCDIAAELARNLIDDDGNNQWPEILKF 131

  Fly   133 LFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAF 197
            ||...||....|:|:||.||.:.|.|||||:..|:::||:||.:.|....:|::|..:.||..:|
Zfish   132 LFDSVNSQDVGLREAALHIFWNFPGIFGNQQQHYMEVIKRMLVQCMQDQENPQIRTLSARAAASF 196

  Fly   198 ILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVC 262
            ||  ..|..||:.|||:|:||.::....|:....|| |:||.|:|:.:..||:|||.||...::.
Zfish   197 IL--SNEGNTALLKHFSDLLPGILQAVNESCYRGDD-SVLKSLVEIADTAPKYLRPNLEATLQLS 258

  Fly   263 MKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVA-LIPLILHMMTDLDDDENWSTAD 326
            :|:.:..:..:..|.|.|||:|:|:|.|.:|:||..:  ||| .:|.:|.||.||::||.|:.||
Zfish   259 LKLCADTNLTNMQRQLALEVIVTLSETAAAMLRKHTN--IVAQSVPQMLTMMVDLEEDEEWAMAD 321

  Fly   327 VVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCH 391
            .::|||...|.|..||:|||:||||||||:||::...:..||.:.|||:|.|.|||:||||||||
Zfish   322 ELEDDDFDSNAVAGESALDRIACGLGGKIILPMIKQHIMQMLQNPDWKYRHAGLMALSAIGEGCH 386

  Fly   392 KQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVEN 456
            :||||||.|::|.||.|..|||||||||||||||||:||||.||:||||.:||..||..::|..|
Zfish   387 QQMEAILSEIVSFVLLFCQDPHPRVRYAACNAIGQMATDFAPTFQKKFHDKVISALLQTMEDQSN 451

  Fly   457 PRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVA 521
            |||||||.|||:||:|||||.:|..|||.::..|..|:.:|.:||::||.|||||||||:|||||
Zfish   452 PRVQAHAAAALINFTEDCPKTLLVPYLDSLVQHLHVIMVAKLQELIQKGTKLVLEQVVTSIASVA 516

  Fly   522 DTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLL 586
            ||.|.:||.|||..||.||.|::||...:||:||||||||:||||||||:|||:.||..||.:||
Zfish   517 DTAEEKFVPYYDLFMPSLKHIVENAIQKELRLLRGKTIECISLIGLAVGKEKFMPDASAVMQLLL 581

  Fly   587 VNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVED 651
            ...|:..:|.|||||.||:|:|||||||||||:|:||||:||||:|:||::|||||:||..::|:
Zfish   582 KTQTDFNDLEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMEN 646

  Fly   652 IDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYF 716
            :..|..|.|:|||:||:|.|:|||:::||:||:||||||:||||||.||.|.||:.|:|:|||||
Zfish   647 MSEDDGWEFVNLGDQQSFGIKTAGLEEKATACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYF 711

  Fly   717 HDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETL 781
            |||||.|||||:|.||:||:::||:||..||.|:|..|:|.|.|||:.||.||:::|.|||||.:
Zfish   712 HDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIELM 776

  Fly   782 GPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDI 846
            |..|||.:..:::..|:...:.|||:..:.|.|.|.:||||:.|||.|.::|:.|||||:|:.||
Zfish   777 GDGCLNNEHFEELGGILKAKLEEHFKNQEVRQAKRQDEDYDEQVEETLQDEDENDVYILTKVSDI 841

  Fly   847 THALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPAL 911
            .|::|.:.:.:.||.|||:....|.|:.|.||.||||||||:|||::|.|.|:...|.:.|...:
Zfish   842 LHSIFSSYREKVLPWFEQLLQLIVNLICPHRPWADRQWGLCIFDDVVEHCSPSSFKYAEYFLRPM 906

  Fly   912 VQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISA 976
            :|.:||.:||||||||||.||:.||.||.:.....:.:||||.||....:|..||::.|||.|||
Zfish   907 MQSLCDTSPEVRQAAAYGVGVMAQFGGENYRPAFTEAVPLLVGVIQSADSRAKENVNATENCISA 971

  Fly   977 FAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIV 1041
            .||::||....: ||.|::..|.||||::||.|||.|.:.|||||||.|:|::||.:|.|||:|.
Zfish   972 VAKVMKYRPECV-NVTEILPHWLSWLPLNEDKEEAVHTFNYLCDLIESNNPIVLGPDNTNLPKIF 1035

  Fly  1042 SIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103
            :|||:....:.|:.:.....|:..:::||:.:..:...|.|.|:..||:|:||    |.|.|
Zfish  1036 AIIADGVANESVKGEDGCSKRLANVIRQVQVSGGLWTQCVSALNETQQKAIQD----LLNTA 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	13/27 (48%)
		HEAT repeat	165..216	CDD:293787	19/50 (38%)
		HEAT repeat	235..261	CDD:293787	12/25 (48%)
		HEAT repeat	272..305	CDD:293787	15/33 (45%)
		HEAT repeat	357..385	CDD:293787	12/27 (44%)
		HEAT_2	364..467	CDD:290374	70/102 (69%)
		HEAT_EZ	373..427	CDD:290247	41/53 (77%)
		HEAT repeat	401..429	CDD:293787	21/27 (78%)
		ARM	405..503	CDD:237987	62/97 (64%)
		HEAT repeat	442..473	CDD:293787	18/30 (60%)
		HEAT repeat	485..519	CDD:293787	17/33 (52%)
		HEAT repeat	532..565	CDD:293787	20/32 (63%)
		HEAT repeat	867..894	CDD:293787	16/26 (62%)
		HEAT repeat	906..936	CDD:293787	16/29 (55%)
		HEAT repeat	947..979	CDD:293787	15/31 (48%)
kpnb3	XP_009303669.1	HEAT repeat	89..111	CDD:293787	5/21 (24%)
		HEAT repeat	128..156	CDD:293787	13/27 (48%)
		HEAT repeat	168..199	CDD:293787	12/32 (38%)
		HEAT repeat	212..238	CDD:293787	10/26 (38%)
		HEAT repeat	251..282	CDD:293787	9/30 (30%)
		HEAT repeat	319..341	CDD:293787	10/21 (48%)
		HEAT_2	355..463	CDD:290374	71/107 (66%)
		HEAT repeat	355..383	CDD:293787	13/27 (48%)
		HEAT_EZ	368..422	CDD:290247	41/53 (77%)
		HEAT repeat	395..425	CDD:293787	22/29 (76%)
		HEAT_EZ	409..465	CDD:290247	40/55 (73%)
		HEAT repeat	437..464	CDD:293787	16/26 (62%)
		HEAT repeat	478..515	CDD:293787	20/36 (56%)
		HEAT repeat	527..560	CDD:293787	20/32 (63%)
		HEAT_EZ	915..962	CDD:290247	24/46 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574252
Domainoid	1	1.000	410	1.000	Domainoid score	I656
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1710
Inparanoid	1	1.050	1168	1.000	Inparanoid score	I193
OMA	1	1.010	-	-		QHG53802
OrthoDB	1	1.010	-	-		D56573at33208
OrthoFinder	1	1.000	-	-		FOG0003156
OrthoInspector	1	1.000	-	-		oto38833
orthoMCL	1	0.900	-	-		OOG6_101397
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R602
SonicParanoid	1	1.000	-	-		X2119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800