DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and IPO5

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_005254109.1	Gene:	IPO5 / 3843	HGNCID:	6402	Length:	1115	Species:	Homo sapiens

Alignment Length:	1103	Identity:	578/1103 - (52%)
Similarity:	793/1103 - (71%)	Gaps:	11/1103 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRL 66
            ||:|..|..||.:|||.||.||:||||.|.|:..:.|:|.||..|:|...:||||||||||||||
Human    23 AAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRL 87

  Fly    67 FTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQ 131
            .::.|.:.|..||::.|..:..::|:.:|.|....:|:|:|::.||:||||||||.|||||:.|:
Human    88 LSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEGLK 152

  Fly   132 FLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGA 196
            |||...:|....|:|:||.||.:.|.|||||:..|:|:||:||.:.|.....|.:|..:.||..|
Human   153 FLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAA 217

  Fly   197 FILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEV 261
            |||.:  |:..|:.|||||:||..:....::. .|:|.|:||.|:|:.:..||:|||.||...::
Human   218 FILAN--EHNVALFKHFADLLPGFLQAVNDSC-YQNDDSVLKSLVEIADTVPKYLRPHLEATLQL 279

  Fly   262 CMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVA-LIPLILHMMTDLDDDENWSTA 325
            .:|:.......:..|.|.|||:|:|:|.|.:|:||..:  ||| .||.:|.||.||::||:|:.|
Human   280 SLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTN--IVAQTIPQMLAMMVDLEEDEDWANA 342

  Fly   326 DVVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC 390
            |.::|||...|.|..||:|||:|||||||:|||::...:..||.:.|||:|.|.|||:|||||||
Human   343 DELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGC 407

  Fly   391 HKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVE 455
            |:|||.||:|:::.||.||.|||||||||||||:|||:||||..|:||||.:||..||..::|..
Human   408 HQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQG 472

  Fly   456 NPRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASV 520
            |.||||||.|||:||:|||||::|..|||.::..|.:|:..|.:||::||.|||||||||:||||
Human   473 NQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASV 537

  Fly   521 ADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDML 585
            |||.|.:||.|||..||.||.|::||...:||:||||||||:||||||||:|||:.||.:||.:|
Human   538 ADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLL 602

  Fly   586 LVNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVE 650
            |...|:..::.|||||.||:|:|||||||||||:|:||||:||||:|:||::|||||:||..::|
Human   603 LKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDME 667

  Fly   651 DIDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFY 715
            ::..|..|.|:|||:||:|.|:|||:::|::||:||||||:||||||.||.|.||:.|:|:||||
Human   668 NMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFY 732

  Fly   716 FHDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIET 780
            ||||||.|||||:|.||:||:::||:||..||.|:|..|:|.|.|||:.||.||:::|.|||||.
Human   733 FHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEV 797

  Fly   781 LGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVD 845
            :|..|||.:..:::..|:...:.|||:..:.|...|.:||||:.|||.|.::||.|||||:|:.|
Human   798 MGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862

  Fly   846 ITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPA 910
            |.|::|.:.|.:.||.|||:.|..|.|:.|.||..|||||||:|||:||.|.||...|.:.|...
Human   863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRP 927

  Fly   911 LVQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAIS 975
            ::|||||.:||||||||||.||:.|:.|:.:...|.:.:||||:||....::..||::.|||.||
Human   928 MLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCIS 992

  Fly   976 AFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRI 1040
            |..||:|:....: ||:|::..|.||||:.||.|||...:.|||||||.|||::||.||.|||:|
Human   993 AVGKIMKFKPDCV-NVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKI 1056

  Fly  1041 VSIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103
            .|||||....:.::.:.....|:..:|:||:::..:...|.:.||||||.|:|    ||.|.|
Human  1057 FSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQ----ELLNSA 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	21/50 (42%)
		HEAT repeat	235..261	CDD:293787	12/25 (48%)
		HEAT repeat	272..305	CDD:293787	15/33 (45%)
		HEAT repeat	357..385	CDD:293787	12/27 (44%)
		HEAT_2	364..467	CDD:290374	66/102 (65%)
		HEAT_EZ	373..427	CDD:290247	39/53 (74%)
		HEAT repeat	401..429	CDD:293787	20/27 (74%)
		ARM	405..503	CDD:237987	60/97 (62%)
		HEAT repeat	442..473	CDD:293787	17/30 (57%)
		HEAT repeat	485..519	CDD:293787	17/33 (52%)
		HEAT repeat	532..565	CDD:293787	20/32 (63%)
		HEAT repeat	867..894	CDD:293787	16/26 (62%)
		HEAT repeat	906..936	CDD:293787	18/29 (62%)
		HEAT repeat	947..979	CDD:293787	14/31 (45%)
IPO5	XP_005254109.1	KAP95	31..>652	CDD:227540	336/625 (54%)
		HEAT repeat	111..133	CDD:293787	6/21 (29%)
		HEAT repeat	150..178	CDD:293787	11/27 (41%)
		HEAT repeat	195..217	CDD:293787	6/21 (29%)
		HEAT repeat	235..263	CDD:293787	9/28 (32%)
		HEAT repeat	275..316	CDD:293787	13/40 (33%)
		Importin_rep_4	286..375	CDD:408579	45/90 (50%)
		HEAT repeat	373..405	CDD:293787	16/31 (52%)
		HEAT repeat	417..447	CDD:293787	21/29 (72%)
		HEAT repeat	459..486	CDD:293787	15/26 (58%)
		HEAT repeat	500..537	CDD:293787	20/36 (56%)
		HEAT repeat	549..582	CDD:293787	20/32 (63%)
		Importin_rep_6	783..892	CDD:408599	48/108 (44%)
		HEAT repeat	883..908	CDD:293787	14/24 (58%)
		HEAT repeat	921..954	CDD:293787	19/32 (59%)
		HEAT_EZ	939..984	CDD:404407	20/44 (45%)
		HEAT repeat	964..1000	CDD:293787	16/35 (46%)
		HEAT repeat	1009..1033	CDD:293787	11/23 (48%)
		Importin_rep_5	1023..1069	CDD:408587	27/45 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141345
Domainoid	1	1.000	410	1.000	Domainoid score	I688
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1710
Inparanoid	1	1.050	1178	1.000	Inparanoid score	I196
Isobase	1	0.950	-	0	Normalized mean entropy	S1555
OMA	1	1.010	-	-		QHG53802
OrthoDB	1	1.010	-	-		D56573at33208
OrthoFinder	1	1.000	-	-		FOG0003156
OrthoInspector	1	1.000	-	-		otm42022
orthoMCL	1	0.900	-	-		OOG6_101397
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R602
SonicParanoid	1	1.000	-	-		X2119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750