DRSC/TRiP Functional Genomics Resources

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Protein Alignment Karybeta3 and imb-3

DIOPT Version :10

Sequence 1:NP_524226.1 Gene:Karybeta3 / 40581 FlyBaseID:FBgn0087013 Length:1105 Species:Drosophila melanogaster
Sequence 2:NP_490715.1 Gene:imb-3 / 3565440 WormBaseID:WBGene00002077 Length:1092 Species:Caenorhabditis elegans


Alignment Length:1090 Identity:388/1090 - (35%)
Similarity:631/1090 - (57%) Gaps:50/1090 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLFT 68
            |...|.:|:..|.|.|||:|:||||.|..:....||..|.....:...:.:||....|.|||:..
 Worm     2 DVNQFTELITKLQSADNDIRKQAEEVYEKIEGPTKVAALFEAYTHHTNNSDARSTVLVFLRRVLA 66

  Fly    69 TEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQFL 133
            .::...::.|..|::.::|.::|..:..|....:::||.::::|:|.||||:..:..|..:|:.:
 Worm    67 RDWDAIWETLNEENKQRILAKVLEMIVHETELSIKKKIADLISEIASNLIDDSGDMTWGGVLELM 131

  Fly   134 FQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAFI 198
            ..|..|........||.|....|.||||:.|.::..:|.:|.|.| |..|.:::..|||||.||.
 Worm   132 DHCLKSEDLTGNYIALLILRGCPIIFGNRLAHFLPTLKVVLEKCM-ATPDLQIKATAVRAVIAFA 195

  Fly   199 LYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCM 263
            :.:|:|.:  :.:....::|.::.:..||.:..|....|....|:..:.||.|...:..:.:|.:
 Worm   196 VDNDEEKD--VVRLMTSLVPNVLQVCNETSDEDDSDGPLGEFAELASSLPKCLNTHMSQVLQVTL 258

  Fly   264 KVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDLDDD--ENWSTAD 326
            .:..:::..:..|...:||:.|..|:||..::|.|...:..::..:|..||::|||  ..|.. :
 Worm   259 AIAGNKEKNEMVRQNAIEVICSYMESAPKGLKKYAPGALGPILETLLSCMTEMDDDVLNEWLN-E 322

  Fly   327 VVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCH 391
            :.:::|:.|..:||||::||:||.:.||::||:.:..:..:|...|||.:.|||.|.||:||||.
 Worm   323 IEEEEDYEDIPIIAESAIDRVACCINGKVMLPVFLPLVEKLLTSEDWKMKHAALRAFSAVGEGCQ 387

  Fly   392 KQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVEN 456
            :.||..::::|:.:.|:::|.||||:|||||||||||:|||.|.:||.|:.|||.||..||..:.
 Worm   388 RSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCHAAVIPALLESLDRTDV 452

  Fly   457 PRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVA 521
            |||.|||.:|||||:|:|||:|:.:||..|:.|||.:|::.|..|.:|..::|:|.:||.|||||
 Worm   453 PRVCAHAASALVNFAEECPKSIIGQYLPFILQKLENVLSAVFNRLGDKRYQVVVENIVTAIASVA 517

  Fly   522 DTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLL 586
            :..|..|..::.||:|.|..|:||..  :|:.||||||||:||||.|||:|:|...|.|::::| 
 Worm   518 EAAEELFKEHHARLIPNLVHILQNVG--ELKELRGKTIECISLIGYAVGKEQFHATAIEILNLL- 579

  Fly   587 VNHTEG-GELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVE 650
               .:| .:||.||||.||:|::|.|.|.|||..|..:||:||.||:|.|..:|:..:.:|::|.
 Worm   580 ---GDGMKDLAIDDPQYSYMISSWTRFCSILGADFAPFLPVVMDPVLRAARYRPDFNIFNNEDVH 641

  Fly   651 DIDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFY 715
            :.:..|::.  .:|.::...|||:|:::||:||:|||.:|:|:||.|..|..||....:..|.|.
 Worm   642 ENEEGVEYH--GIGGEKTVGIRTSGLEEKATACDMLVAFAKEMKEAFMPYVVDVYELAIKNLDFG 704

  Fly   716 FHDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVT--EPEPDVQ--SELLNSLAK 776
            .|||||||:||.:|.||.|.:.:|......:|   | |.||.:.|  |.|.||:  :..:.::..
 Worm   705 LHDGVRTASAEIMPCLLTCVEKQGLADKRRLW---C-EFLKALTTSMEEEDDVEILASFMTTIGS 765

  Fly   777 CIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQD---DTDVY 838
            |||.:....:.|:.::.::.::    |:..|...||::.|..||.||...|...|.|   :.:..
 Worm   766 CIEVMKTEGIAEEEVQLIISVL----LKQLENYGKRMSDRPVEDEDDDDAEAKEELDYFMELEAS 826

  Fly   839 ILSKIVDITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEF-CGPACAP 902
            .|..|.|:||:|.:..|.........|....::|:|.|:...:||||:|:.||.||| .|.....
 Worm   827 CLGAISDLTHSLMKEFKGTIFEGMINVFNCAIQLIEGSKQYFERQWGMCLLDDAIEFGVGHMPTR 891

  Fly   903 YQQIFTPALVQYVCDKAPEVRQAAAYGCGV-------LGQFAGEQFAHTCAQIIPLLVQVINDPK 960
            :.::. |.:.:.:.|:.|||||||:||.||       :..:..|..  :|.:.:..::| ..|.:
 Worm   892 FPKLI-PIMYKLLGDEYPEVRQAASYGFGVMAINYHQISDYRNEIL--SCLEPLAAMIQ-REDAR 952

  Fly   961 AREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGN 1025
            |.| |:...|||||||||||:...........:::.::.||||...|:||:.:||..|.:|.:..
 Worm   953 ATE-ESTVATENAISAFAKIIGNVPLPAEAYGKVVEMFLSWLPTYSDTEESPYIYTCLAELFDKQ 1016

  Fly  1026 HPVILGANNGNLPRI-----VSIIAESFCTKVVEAQSATGTRMLTIVKQV 1070
            ...:.|..|.|||||     :||..::|...  ::.:.|..|::||:||:
 Worm  1017 DAALFGPENQNLPRIFLVCLLSIANDAFNDD--DSGNQTKQRIVTILKQI 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Karybeta3NP_524226.1 KAP95 6..>625 CDD:227540 233/621 (38%)
HEAT repeat 129..157 CDD:293787 6/27 (22%)
HEAT repeat 165..216 CDD:293787 15/50 (30%)
HEAT repeat 235..261 CDD:293787 5/25 (20%)
Importin_rep_4 268..358 CDD:408579 28/91 (31%)
HEAT repeat 272..305 CDD:293787 9/32 (28%)
HEAT repeat 357..385 CDD:293787 10/27 (37%)
HEAT repeat 401..429 CDD:293787 17/27 (63%)
HEAT repeat 442..473 CDD:293787 18/30 (60%)
HEAT repeat 485..519 CDD:293787 13/33 (39%)
HEAT repeat 532..565 CDD:293787 17/32 (53%)
Importin_rep_6 766..875 CDD:465881 26/113 (23%)
HEAT repeat 867..894 CDD:293787 10/26 (38%)
HEAT repeat 906..936 CDD:293787 13/36 (36%)
HEAT repeat 947..979 CDD:293787 13/31 (42%)
Importin_rep_5 1007..1059 CDD:465877 17/56 (30%)
imb-3NP_490715.1 KAP95 <218..>486 CDD:227540 106/268 (40%)
HEAT repeat 249..283 CDD:293787 5/33 (15%)
Importin_rep_4 263..354 CDD:408579 28/91 (31%)
HEAT repeat 356..384 CDD:293787 10/27 (37%)
HEAT repeat 396..426 CDD:293787 18/29 (62%)
HEAT repeat 438..465 CDD:293787 15/26 (58%)
HEAT repeat 526..559 CDD:293787 17/34 (50%)
HEAT 895..922 CDD:460773 13/27 (48%)

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