DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and Fs(2)Ket

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	203/984 - (20%)
Similarity:	354/984 - (35%)	Gaps:	310/984 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAADQAHFQQLLA-----------SLLSTDNDVRQQAEEAYNNLSRELK-VTHLLGNIQNGQQSE 53
            |.:|.|  .||:|           .|||..|.:.|.|.   :||...|| ::.:|.|..|   |.
  Fly     1 MTSDIA--MQLIAILEKTVSPDKNELLSAKNFLEQAAA---SNLPEFLKALSEILVNTAN---SA 57

  Fly    54 EARQMAAVLLRRLFTT-------EFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKIC--EV 109
            .||..|.:.|:...|:       ::.|.:...|:|.:..:...||.|:..|.|    |..|  :.
  Fly    58 VARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENT----RPSCAAQC 118

  Fly   110 VAEVARNLIDEDCNNQWPDILQFLFQ--CANSPTPQLQESALRIFSSV--PSIFGNQEAQYIDLI 170
            ||.||   :.|...|:||.::|.|..  .:...:...:||||.....:  ...||..|.|..|::
  Fly   119 VAYVA---VIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVL 180

  Fly   171 KQMLAKSMDAGSDPEVRVQAVRAVGAFILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQ- 234
            ..::...........||:.|..|:...:.:.....|..:.::|      ::.:..|..:.||.|
  Fly   181 TAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNF------IMEVVCEATQCQDSQI 239

  Fly   235 --SLLKLLIEMTENCPKFLRPQL-EFIFEVCMKVFSSQDFE------DSWRHLVLEVMVSLA--- 287
              :.|:.|:::.....:::.|.: :.:|.:.:....|.:..      :.|.: |.:..:.||
  Fly   240 CVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSN-VCDEEIDLAIES 303

  Fly   288 ------ENAPSMIRKR-ADKYIVALIPLILHMMT---DLDDDENWSTADVVDDDDHSDNNVIAES 342
                  ..||..:.|. |...:..|.|:::..:|   :.||::.||.|..            |..
  Fly   304 QEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKA------------ASV 356

  Fly   343 SLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCH-KQMEAILDEVMSGVL 406
            .|..||.....:|| |.|:..:...:...:|:.|.||:|...::..|.. ..::.::::.|..::
  Fly   357 CLMVLATCCEDEIV-PHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLI 420

  Fly   407 NFLSDPHPRVRYA-------ACNAIGQ--MSTDFAQT----FEKKFHSQVIPGLLSLLDDVENPR 458
            ..:.|....||..       .|:.|.:  ::..:.||    |.|...|:              ||
  Fly   421 RLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSE--------------PR 471

  Fly   459 VQAHAGAALVNFSE-----------DCPKN---------ILTRYL------DGIMAKLETILNSK 497
            |.|:...|.:..|:           :.|:.         |:|:.|      ||..|.|.......
  Fly   472 VAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQA 536

  Fly   498 FKELVEKGNKLVLEQVV--TTIASVADTCESEFVAYYDRLMPCLKFIIQ-NANSD-----DLRML 554
            ..::: |.:.|....||  ||:..:            :||...::...| |.:||     ||:.|
  Fly   537 LMDMI-KNSPLDCYLVVQRTTLVIL------------ERLNQVMQMETQINNHSDRHQFNDLQSL 588

  Fly   555 RGKTIECVSLIGLAVGREKFIGDAGEVMDMLLV------NHTEG--GELADDDPQTSYLITAWAR 611
            ...|::       :|.|:....||.::.|.::.      |.:.|  |.:.::    ::|  |.:.
  Fly   589 LCATLQ-------SVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEE----AFL--AVST 640

  Fly   612 MCKILGKQFEQYLP-----LVMGPVMRTATMKPEVAMLDNDEVEDIDGDVDWSFINLGEQQNFAI 671
            :.::||.||.:|:|     ||||                                    .:||.
  Fly   641 LVELLGAQFAKYMPAFKDFLVMG------------------------------------LKNFQ- 668

  Fly   672 RTAGMDDKASACEMLVCYA---------RELKEGFAEYAEDVV-------------RQMLPMLKF 714
                        |..||.|         |.||:....|:.:::             |.:.|.:..
  Fly   669 ------------EYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLS 721

  Fly   715 YFHDGVRTAAAESLPYL---LDCAKIKGP-----------------------------QYLEGM- 746
            .|.|...:.....||||   ||..::...                             |.|:|:
  Fly   722 AFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVD 786

  Fly   747 ------WMFICPELLKVIV----TEPEPDVQSELLNSLAKCIETL----GPNC--LNEDAMKQVL 795
                  .|.:.|.|:.:|.    ...|.||...:|.|.|..|..|    ||..  |.:||
  Fly   787 QTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDA----- 846

  Fly   796 EIINKYVLE 804
             ||.:::.|
  Fly   847 -IITQFLAE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	6/31 (19%)
		HEAT repeat	165..216	CDD:293787	8/50 (16%)
		HEAT repeat	235..261	CDD:293787	4/26 (15%)
		HEAT repeat	272..305	CDD:293787	8/48 (17%)
		HEAT repeat	357..385	CDD:293787	7/27 (26%)
		HEAT_2	364..467	CDD:290374	21/116 (18%)
		HEAT_EZ	373..427	CDD:290247	12/63 (19%)
		HEAT repeat	401..429	CDD:293787	6/36 (17%)
		ARM	405..503	CDD:237987	24/136 (18%)
		HEAT repeat	442..473	CDD:293787	6/41 (15%)
		HEAT repeat	485..519	CDD:293787	9/35 (26%)
		HEAT repeat	532..565	CDD:293787	10/38 (26%)
		HEAT repeat	867..894	CDD:293787
		HEAT repeat	906..936	CDD:293787
		HEAT repeat	947..979	CDD:293787
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	197/966 (20%)
		IBN_N	27..107	CDD:281761	22/85 (26%)
		HEAT repeat	136..162	CDD:293787	6/25 (24%)
		HEAT repeat	179..209	CDD:293787	4/29 (14%)
		HEAT repeat	223..255	CDD:293787	7/37 (19%)
		HEAT repeat	264..291	CDD:293787	3/26 (12%)
		HEAT repeat	330..360	CDD:293787	9/41 (22%)
		HEAT repeat	373..401	CDD:293787	6/27 (22%)
		HEAT_EZ	386..441	CDD:290247	10/54 (19%)
		HEAT repeat	414..444	CDD:293787	5/29 (17%)
		HEAT repeat	457..482	CDD:293787	9/38 (24%)
		HEAT repeat	508..540	CDD:293787	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940