DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and Ranbp6

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001101054.1	Gene:	Ranbp6 / 309326	RGDID:	1305165	Length:	1105	Species:	Rattus norvegicus

Alignment Length:	1092	Identity:	527/1092 - (48%)
Similarity:	741/1092 - (67%)	Gaps:	5/1092 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLF 67
            :|:..|.|||.:|::....||:||||.|.|:....|.|.||..::|.:...|.|||||.|||||.
  Rat    14 SDKQEFYQLLKNLINPSCMVRRQAEEVYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLL 78

  Fly    68 TTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQF 132
            ::.|.:.|..||:|.|..:..:::|||:.|....:|:|:|::.|.:|||||||:..|.||:.|:|
  Rat    79 SSGFEEVYPNLPSEVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDENGTNHWPEGLKF 143

  Fly   133 LFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAF 197
            |....:|....|.|.||.:|...|.|||||:...:|:||::|.:.:.....|.:|..:.||..||
  Rat   144 LIDSIHSKNVVLWEVALHVFWHFPGIFGNQDRHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAF 208

  Fly   198 ILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVC 262
            :|.:  ||..|:.|.|||:||.::....::. .|||.|:|:.|:|:.:..||:|.|.||...::.
  Rat   209 VLAN--ENNIALFKDFADLLPGILQAVNDSC-YQDDDSVLESLVEIADTVPKYLGPYLEDTLQLS 270

  Fly   263 MKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTADV 327
            :|:.......:..|.|.|||:|:|:|.|..|::|..: .|...:|.||.||.||.||::|..||.
  Rat   271 LKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTN-IIAQAVPHILAMMVDLQDDDDWVNADE 334

  Fly   328 VDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCHK 392
            :::||...|.|.|||:|||||||||||:|||:....:..||...|||.|.|.|||:||||||||:
  Rat   335 MEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSHDWKCRHAGLMALSAIGEGCHQ 399

  Fly   393 QMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENP 457
            |||.||||.::.||.||.|||||||.|||..:|||:||||.:|:||||..||..||..:::..|.
  Rat   400 QMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPSFQKKFHEIVITALLRTMENQGNQ 464

  Fly   458 RVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVAD 522
            |||:.|.:|||.|.|||||::|..||:.::..|::||..|.:||:..|.||.|||:|||||||||
  Rat   465 RVQSQAASALVIFIEDCPKSLLILYLENMVKSLQSILVIKLQELIRNGTKLALEQLVTTIASVAD 529

  Fly   523 TCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLV 587
            ..|..|:.|||..||.||.:::.|...:|::||||||||:|.:|||||:|||:.||..||.:||.
  Rat   530 VIEENFIPYYDIFMPSLKHVVELAVQKELKLLRGKTIECISHVGLAVGKEKFMQDASNVMQILLK 594

  Fly   588 NHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVEDI 652
            ..::...:.:|||||||:::|||||||||||.||||||||:.|:::||:.||:||:||..:||::
  Rat   595 TQSDLNNMEEDDPQTSYMVSAWARMCKILGKDFEQYLPLVIEPLIKTASAKPDVALLDTQDVENM 659

  Fly   653 DGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYFH 717
            ..|..|.|:|||:||:|.|:|:|::.||:||:|||.||:||:|||.||.|.||:.|:|:||||||
  Rat   660 SDDEGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKMMVPLLKFYFH 724

  Fly   718 DGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETLG 782
            |.||.||||::|:||:||:|:|.:||..||.|||..|:|.|.|||:.||.||::||.||.||.:|
  Rat   725 DNVRMAAAEAMPFLLECARIRGSEYLSQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMG 789

  Fly   783 PNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDIT 847
            ..|||::.::::..|:...:..||:..:.|...|.||:||..||..|.::|:.|||||:|:.||.
  Rat   790 DGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDIL 854

  Fly   848 HALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPALV 912
            |:||.|.|.:.||.|||:.|..|.|:..|||..|||||||:|||:||.|.|....|.:.|...::
  Rat   855 HSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPML 919

  Fly   913 QYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISAF 977
            ..:.|..||||||||||.||:.||.|:.:...|::.:||||:||....::..:|:..|||.|||.
  Rat   920 LNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAI 984

  Fly   978 AKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIVS 1042
            .||:|:..:.: ||||::..|.||||:.||.|||.....:||||||.||||::|.||.|||:|:|
  Rat   985 GKIMKFKPNCV-NVDEVLPHWLSWLPLHEDKEEAIQTLNFLCDLIESNHPVVIGPNNSNLPKIIS 1048

  Fly  1043 IIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQD 1094
            ||||....:.:..:.....|:..:|:|::::.|:...|.|.|..|||:|||:
  Rat  1049 IIAEGKINETISLEDPCAKRLANVVRQIQTSEELWLECTSQLDDEQQEALQE 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	9/27 (33%)
		HEAT repeat	165..216	CDD:293787	17/50 (34%)
		HEAT repeat	235..261	CDD:293787	10/25 (40%)
		HEAT repeat	272..305	CDD:293787	12/32 (38%)
		HEAT repeat	357..385	CDD:293787	12/27 (44%)
		HEAT_2	364..467	CDD:290374	60/102 (59%)
		HEAT_EZ	373..427	CDD:290247	37/53 (70%)
		HEAT repeat	401..429	CDD:293787	17/27 (63%)
		ARM	405..503	CDD:237987	53/97 (55%)
		HEAT repeat	442..473	CDD:293787	13/30 (43%)
		HEAT repeat	485..519	CDD:293787	16/33 (48%)
		HEAT repeat	532..565	CDD:293787	17/32 (53%)
		HEAT repeat	867..894	CDD:293787	16/26 (62%)
		HEAT repeat	906..936	CDD:293787	14/29 (48%)
		HEAT repeat	947..979	CDD:293787	13/31 (42%)
Ranbp6	NP_001101054.1	HEAT repeat	330..353	CDD:293787	10/22 (45%)
		HEAT repeat	363..395	CDD:293787	16/31 (52%)
		HEAT_2	371..474	CDD:290374	60/102 (59%)
		HEAT_EZ	380..434	CDD:290247	37/53 (70%)
		HEAT repeat	407..437	CDD:293787	18/29 (62%)
		HEAT repeat	449..476	CDD:293787	11/26 (42%)
		HEAT repeat	502..526	CDD:293787	13/23 (57%)
		HEAT repeat	539..572	CDD:293787	17/32 (53%)
		HEAT repeat	873..898	CDD:293787	14/24 (58%)
		HEAT repeat	910..942	CDD:293787	15/31 (48%)
		HEAT_EZ	927..987	CDD:290247	29/59 (49%)
		HEAT repeat	954..990	CDD:293787	15/35 (43%)
		HEAT repeat	999..1023	CDD:293787	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335018
Domainoid	1	1.000	411	1.000	Domainoid score	I663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1186	1.000	Inparanoid score	I186
OMA	1	1.010	-	-		QHG53802
OrthoDB	1	1.010	-	-		D56573at33208
OrthoFinder	1	1.000	-	-		FOG0003156
OrthoInspector	1	1.000	-	-		otm46166
orthoMCL	1	0.900	-	-		OOG6_101397
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910