DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and Ipo5

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_006252540.1	Gene:	Ipo5 / 306182	RGDID:	1308715	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	1102	Identity:	578/1102 - (52%)
Similarity:	792/1102 - (71%)	Gaps:	9/1102 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRL 66
            ||:|..|..||.:|||.||.||:||||.|.|:....|:|.||..|:|...:||||||||||||||
  Rat     5 AAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGRSKITFLLQAIRNTTAAEEARQMAAVLLRRL 69

  Fly    67 FTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQ 131
            .::.|.:.|..||::.|..:..::|:.:|.|....:|:|||::.||:||||||||.|||||:.|:
  Rat    70 LSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKICDIAAELARNLIDEDGNNQWPEGLK 134

  Fly   132 FLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGA 196
            |||...:|....|:|:||.||.:.|.|||||:..|:|:||:||.:.|.....|.:|..:.||..|
  Rat   135 FLFDSVSSQNMGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAA 199

  Fly   197 FILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEV 261
            |||.:  |:..|:.|||||:||..:....::. .|:|.|:||.|:|:.:..||:|||.||...::
  Rat   200 FILAN--EHNVALFKHFADLLPGFLQAVNDSC-YQNDDSVLKSLVEIADTVPKYLRPHLEATLQL 261

  Fly   262 CMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTAD 326
            .:|:....:..:..|.|.|||:|:|:|.|.:|:||..: .|...||.:|.||.||::||:|:.||
  Rat   262 SLKLCGDTNLNNMQRQLALEVIVTLSETAAAMLRKHTN-IIAQTIPQMLAMMVDLEEDEDWANAD 325

  Fly   327 VVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCH 391
            .::|||...|.|..||:|||:|||||||:|||::...:..||.:||||:|.|.|||:||||||||
  Rat   326 ELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNADWKYRHAGLMALSAIGEGCH 390

  Fly   392 KQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVEN 456
            :|||.||:|:::.||.||.|||||||||||||:|||:||||..|:||||.:||..||..::|..|
  Rat   391 QQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGN 455

  Fly   457 PRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVA 521
            .||||||.|||:||:|||||::|..|||.::..|.:|:..|.:||::||.|||||||||:|||||
  Rat   456 QRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVA 520

  Fly   522 DTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLL 586
            ||.|.:||.|||..||.||.|::||...:||:||||||||:||||||||:|||:.||.:||.:||
  Rat   521 DTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLL 585

  Fly   587 VNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVED 651
            ...|:..::.|||||.||:|:|||||||||||:|:||||:||||:|:||::|||||:||..::|:
  Rat   586 KTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMEN 650

  Fly   652 IDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYF 716
            :..|..|.|:|||:||:|.|:|||:::|::||:||||||:||||||.||.|.||:.|:|:|||||
  Rat   651 MSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYF 715

  Fly   717 HDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETL 781
            |||||.|||||:|.||:||:::||:||..||.|:|..|:|.|.|||:.||.||:::|.|||||.:
  Rat   716 HDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM 780

  Fly   782 GPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDI 846
            |..|||.:..:::..|:...:.|||:..:.|...|.:||||:.|||.|.::||.|||||:|:.||
  Rat   781 GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDI 845

  Fly   847 THALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPAL 911
            .|::|.:.|.:.||.|||:.|..|.|:.|.||..|||||||:|||:||.|.||...|.:.|...:
  Rat   846 LHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDIIEHCSPASFKYAEYFLRPM 910

  Fly   912 VQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISA 976
            :|||||.:||||||||||.||:.|:.|:.:...|.:.:||||:||....::..||::.|||.|||
  Rat   911 LQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCISA 975

  Fly   977 FAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIV 1041
            ..||:|:....: ||:|::..|.||||:.||.|||...:.|||||||.|||::||.||.|||:|.
  Rat   976 VGKIMKFKPDCV-NVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNHPIVLGPNNTNLPKIF 1039

  Fly  1042 SIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103
            |||||....:.::.:.....|:..:|:||:::..:...|.:.||||||.|:|    ||.|.|
  Rat  1040 SIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQ----ELLNSA 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	11/27 (41%)
		HEAT repeat	165..216	CDD:293787	21/50 (42%)
		HEAT repeat	235..261	CDD:293787	12/25 (48%)
		HEAT repeat	272..305	CDD:293787	13/32 (41%)
		HEAT repeat	357..385	CDD:293787	13/27 (48%)
		HEAT_2	364..467	CDD:290374	67/102 (66%)
		HEAT_EZ	373..427	CDD:290247	39/53 (74%)
		HEAT repeat	401..429	CDD:293787	20/27 (74%)
		ARM	405..503	CDD:237987	60/97 (62%)
		HEAT repeat	442..473	CDD:293787	17/30 (57%)
		HEAT repeat	485..519	CDD:293787	17/33 (52%)
		HEAT repeat	532..565	CDD:293787	20/32 (63%)
		HEAT repeat	867..894	CDD:293787	16/26 (62%)
		HEAT repeat	906..936	CDD:293787	18/29 (62%)
		HEAT repeat	947..979	CDD:293787	14/31 (45%)
Ipo5	XP_006252540.1	KAP95	13..>634	CDD:227540	336/624 (54%)
		HEAT repeat	177..199	CDD:293787	6/21 (29%)
		HEAT repeat	217..245	CDD:293787	9/28 (32%)
		HEAT repeat	257..298	CDD:293787	13/40 (33%)
		Importin_rep_4	268..357	CDD:408579	43/89 (48%)
		HEAT repeat	355..387	CDD:293787	17/31 (55%)
		HEAT repeat	399..429	CDD:293787	21/29 (72%)
		HEAT repeat	441..468	CDD:293787	15/26 (58%)
		HEAT repeat	482..519	CDD:293787	20/36 (56%)
		HEAT repeat	531..564	CDD:293787	20/32 (63%)
		Importin_rep_6	765..874	CDD:408599	48/108 (44%)
		HEAT repeat	865..890	CDD:293787	14/24 (58%)
		HEAT repeat	903..936	CDD:293787	19/32 (59%)
		HEAT_EZ	921..966	CDD:404407	20/44 (45%)
		HEAT repeat	946..982	CDD:293787	16/35 (46%)
		HEAT repeat	991..1015	CDD:293787	11/23 (48%)
		Importin_rep_5	1005..1051	CDD:408587	27/45 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335017
Domainoid	1	1.000	411	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1710
Inparanoid	1	1.050	1186	1.000	Inparanoid score	I186
OMA	1	1.010	-	-		QHG53802
OrthoDB	1	1.010	-	-		D56573at33208
OrthoFinder	1	1.000	-	-		FOG0003156
OrthoInspector	1	1.000	-	-		otm46166
orthoMCL	1	0.900	-	-		OOG6_101397
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2119
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770