DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Karybeta3 and Ipo4

DIOPT Version :9

Sequence 1:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001099508.1	Gene:	Ipo4 / 290228	RGDID:	1305206	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	1125	Identity:	252/1125 - (22%)
Similarity:	465/1125 - (41%)	Gaps:	180/1125 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLFT 68
            :.|..:|:|..||..|.:..::|.|......|:......|.::.......:.||.||||.||..:
  Rat     2 EPAGLEQILKELLMPDTERIRRATEQLQTALRDPAALPALCDLLASATDPQIRQFAAVLTRRRLS 66

  Fly    69 TEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWP---DIL 130
            ..    ::.|..|.:..|...:|.|:|:|....:...:.::.|.:.|    ::....||   ::|
  Rat    67 NR----WRRLAPEQRESLKSLVLTALQKETEHYVSVSLAQLSATIFR----KEGLQGWPQFMNLL 123

  Fly   131 QFLFQCANSPTPQLQESALR-IFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAV 194
            |.....|:||..::....|. :.||.|..|...:.:.:    |:|.:::...|.|.|...::|.:
  Rat   124 QHSTHSAHSPEKEVGLLLLSVVVSSQPEAFHAHQQELL----QLLIETLSEVSFPGVLFYSLRTL 184

  Fly   195 GAFILYHDKENETAIHKHFADML-PRMIHITGETIEAQDDQS--LLKLLIEMTENCPKFLRPQLE 256
            .|...|...::.:     .|.|| |:::......|...:.::  .|:.|.||.|.....:.|.|.
  Rat   185 TALARYLRPDDVS-----LARMLVPKVVTALRTLIPLDEVKACEALEALDEMLETELPIITPHLS 244

  Fly   257 FIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAE-NAPSMIRKRADKYIVALIPLILHM-------- 312
            .:...|::|..:....::.|..:|..:..|.: .:.::::.|       |:|.:|:.
  Rat   245 EVLTFCLEVAKNVALGEAIRVRILCCLTFLVKVKSKALLKNR-------LLPPLLNALFPIMAAE 302

  Fly   313 --MTDLDDDENWSTADVVDDDDHSDNNVIAESS-------LDRLACGLGGKIVLPLVMNALPVML 368
              :..||.::..|      |||..:..::.|:.       :|.||..|..:.:.|.||..|...|
  Rat   303 PPLGQLDPEDQDS------DDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEAL 361

  Fly   369 GHADWKHRFAALMAISAIGEGCHKQM-EAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFA 432
            .......|.|..:.::.:.:|....: :.:|..::..|...|.||...||.||..|:||.|.:.
  Rat   362 RSEAPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQVVRNAALFALGQFSENL- 425

  Fly   433 QTFEKKFHSQVIPGLLSLLDDVE--NPRVQAHAGAALVNFSEDC-PKNILTRYLDGIM-AKLETI 493
            |.....:..:|:|.||:.|..|.  |....|.|..||.||.|:. ||  :..||..:| ..|:.:
  Rat   426 QPHISSYSEEVMPLLLTYLKSVPMGNTHHLAKACYALENFVENLGPK--VQPYLPELMECMLQPL 488

  Fly   494 LN---SKFKELVEKGNKLVLEQVVTTIASVADTCESEFVAYYDRLMPCLK-FIIQNANSDDLRML 554
            .|   ::.|||           .|:.|.::|...:...:.|:..:|..:: |::  ...|||.::
  Rat   489 KNPSKARTKEL-----------AVSAIGAIATAAQDSLLPYFPTVMEHIREFLL--TGHDDLHLV 540

  Fly   555 RGKTIECVSLIGLAVGRE-KFIGDAGEVMDMLLVNHTEGGELADDDP---QTSYLITAWARMCKI 615
            :.:::|.:.::..|:|.. |.:.:....:.:.|..|.       |||   :.:|  :.:|.:..:
  Rat   541 QIQSLETLGVLARALGESMKPLAEECCQLGLGLCIHV-------DDPDVRRCTY--SLFAALSGL 596

  Fly   616 LGKQFEQYLP----LVMGPVMRTATMKPE-------VAMLDNDEV--------EDIDGDVDWSFI 661
            :|:....|||    |::..:..|..:.|:       :...|:.|.        ||::.:.|.|
  Rat   597 MGESLGPYLPQITTLMLLSLRSTEGIVPQYDGISSFLLFEDDSEAEEEEELMDEDMEEEEDDS-- 659

  Fly   662 NLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYFHDGVRTAAAE 726
               |...:::..|..|:|...|..|...:......|..:.:.:..::..:|:.. |..||.||.|
  Rat   660 ---EISGYSVENAFFDEKEDTCTALGEISMNTSVAFLPFMDAIFDEVYKLLECP-HMNVRKAAYE 720

  Fly   727 SLPYLLDCAKIK----GPQ-----YLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETLG 782
            :|.... ||..|    ||.     .|:.......|..::.:..|.|..|...:|.:|...:.|.|
  Rat   721 ALGQFC-CALHKACQRGPSDPNNAALQSSLARAIPSYMQAVKVERERPVVMAVLEALTGVLRTCG 784

  Fly   783 ------PNCLNE--DAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYI 839
                  |..|:|  :.:|.||:              |:.|.::.|: ||..:::.||.|...:..
  Rat   785 ALTLQPPGRLSELCNVLKAVLQ--------------KKTACQDAEE-DDDEDDDQAEYDAMLLEH 834

  Fly   840 LSKIVDIT------HALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGP 898
            ..:.:.:.      ||        |.|.|....|..:...:.|..||::.:.:....:.|:..|.
  Rat   835 AGEAIPVLAAAAGGHA--------FAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGA 891

  Fly   899 ACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAG----EQFAHTCAQIIPLLVQVINDP 959
            |.|.:.....|.|:....:..||||..|.:|.|||.:..|    :.|......::|||.:..:|
  Rat   892 ASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHD- 955

  Fly   960 KAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEG 1024
            :.|        :|...|.|::|..:.:..:. .:::......||:.||.||...| |:|...:..
  Rat   956 RVR--------DNICGALARLLMASPAGKTE-PQVLATLLHALPLKEDMEEWVTI-GHLFSFLHQ 1010

  Fly  1025 NHPVILGANNGNLPRIVSII 1044
            |:|..:......|.||.|:|
  Rat  1011 NNPDQVVGVASELLRICSLI 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	8/28 (29%)
		HEAT repeat	165..216	CDD:293787	9/50 (18%)
		HEAT repeat	235..261	CDD:293787	7/27 (26%)
		HEAT repeat	272..305	CDD:293787	4/33 (12%)
		HEAT repeat	357..385	CDD:293787	7/27 (26%)
		HEAT_2	364..467	CDD:290374	28/105 (27%)
		HEAT_EZ	373..427	CDD:290247	14/54 (26%)
		HEAT repeat	401..429	CDD:293787	11/27 (41%)
		ARM	405..503	CDD:237987	37/104 (36%)
		HEAT repeat	442..473	CDD:293787	13/32 (41%)
		HEAT repeat	485..519	CDD:293787	8/37 (22%)
		HEAT repeat	532..565	CDD:293787	6/33 (18%)
		HEAT repeat	867..894	CDD:293787	4/26 (15%)
		HEAT repeat	906..936	CDD:293787	11/29 (38%)
		HEAT repeat	947..979	CDD:293787	7/31 (23%)
Ipo4	NP_001099508.1	KAP95	1..>620	CDD:227540	150/672 (22%)
		IBN_N	24..90	CDD:197981	17/69 (25%)
		HEAT repeat	353..381	CDD:293787	6/27 (22%)
		HEAT repeat	394..424	CDD:293787	12/29 (41%)
		HEAT	395..425	CDD:281045	12/29 (41%)
		HEAT repeat	435..464	CDD:293787	11/28 (39%)
		HEAT repeat	477..507	CDD:293787	9/40 (23%)
		HEAT repeat	666..688	CDD:293787	5/21 (24%)
		HEAT repeat	698..726	CDD:293787	8/28 (29%)
		HEAT repeat	900..928	CDD:293787	11/27 (41%)
		HEAT repeat	941..971	CDD:293787	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810