DRSC/TRiP Functional Genomics Resources

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Protein Alignment Karybeta3 and RANBP6

DIOPT Version :9

Sequence 1:NP_001262259.1 Gene:Karybeta3 / 40581 FlyBaseID:FBgn0087013 Length:1105 Species:Drosophila melanogaster
Sequence 2:NP_036548.1 Gene:RANBP6 / 26953 HGNCID:9851 Length:1105 Species:Homo sapiens


Alignment Length:1101 Identity:538/1101 - (48%)
Similarity:746/1101 - (67%) Gaps:9/1101 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRLF 67
            :::..|.|||.:|::....||:||||.|.|:....|.|.||..::|.:...|.|||||.|||||.
Human    14 SEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLL 78

  Fly    68 TTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQF 132
            ::.|.:.|..|||:.|..:..:::|||:.|....:|:|:|::.|.:||||||||..|.||:.|:|
Human    79 SSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPEGLKF 143

  Fly   133 LFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGAF 197
            |.....|....|.|.||.:|...|.|||.||...:|:||::|.:.:.....|.:|..:.||..||
Human   144 LIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAF 208

  Fly   198 ILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVC 262
            :|.:  ||..|:.|.|||:||.::....::. .|||.|:|:.|:|:.:..||:|.|.||...::.
Human   209 VLAN--ENNIALFKDFADLLPGILQAVNDSC-YQDDDSVLESLVEIADTVPKYLGPYLEDTLQLS 270

  Fly   263 MKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDLDDDENWSTADV 327
            :|:.......:..|.|.|||:|:|:|.|..|::|..: .|...:|.||.||.||.|||:|..||.
Human   271 LKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTN-IIAQAVPHILAMMVDLQDDEDWVNADE 334

  Fly   328 VDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGCHK 392
            :::||...|.|.|||:|||||||||||:|||:....:..||...|||:|.|.|||:||||||||:
Human   335 MEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQ 399

  Fly   393 QMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENP 457
            |||:||||.::.||.||.|||||||.|||..:|||:||||..|:||||..||..||..:::..|.
Human   400 QMESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQ 464

  Fly   458 RVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVAD 522
            |||:||.:||:.|.|||||::|..|:|.::..|.::|..|.:||:..|.||.|||:|||||||||
Human   465 RVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVAD 529

  Fly   523 TCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLV 587
            |.|.:||.|||..||.||.|::.|...:|::||||||||:|.||||||:|||:.||..||.:||.
Human   530 TIEEKFVPYYDIFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLK 594

  Fly   588 NHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVEDI 652
            ..::...:.||||||||:::|||||||||||.|:||||||:.|:::||:.||:||:||..:||::
Human   595 TQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENM 659

  Fly   653 DGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFYFH 717
            ..|..|.|:|||:||:|.|:|:|::.||:||:|||.||:||:|||.||.|.||:.|:|:||||||
Human   660 SDDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLKFYFH 724

  Fly   718 DGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIETLG 782
            |.||.|||||:|:||:||:|:||:||..||.|||..|:|.|.|||:.||.||::||.||.||.:|
Human   725 DNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMG 789

  Fly   783 PNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVDIT 847
            ..|||::.::::..|:...:..||:..:.|...|.||:||..||..|.::|:.|||||:|:.||.
Human   790 DGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDIL 854

  Fly   848 HALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPALV 912
            |:||.|.|.:.||.|||:.|..|.|:..|||..|||||||:|||:||.|.|....|.:.|...::
Human   855 HSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPML 919

  Fly   913 QYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAISAF 977
            ..:.|..||||||||||.||:.||.|:.:...|::.:||||:||....::..:|:..|||.|||.
Human   920 LNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAI 984

  Fly   978 AKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIVS 1042
            .||||:..:.: ||||::..|.||||:.||.|||.....:||||||.||||::|.||.|||:|:|
Human   985 GKILKFKPNCV-NVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIIS 1048

  Fly  1043 IIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103
            ||||....:.:..:.....|:..:|:||:::.::...|.|.|..|||:|||    ||.|.|
Human  1049 IIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLECVSQLDDEQQEALQ----ELLNFA 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Karybeta3NP_001262259.1 HEAT repeat 129..157 CDD:293787 9/27 (33%)
HEAT repeat 165..216 CDD:293787 17/50 (34%)
HEAT repeat 235..261 CDD:293787 10/25 (40%)
HEAT repeat 272..305 CDD:293787 12/32 (38%)
HEAT repeat 357..385 CDD:293787 12/27 (44%)
HEAT_2 364..467 CDD:290374 61/102 (60%)
HEAT_EZ 373..427 CDD:290247 37/53 (70%)
HEAT repeat 401..429 CDD:293787 17/27 (63%)
ARM 405..503 CDD:237987 52/97 (54%)
HEAT repeat 442..473 CDD:293787 13/30 (43%)
HEAT repeat 485..519 CDD:293787 15/33 (45%)
HEAT repeat 532..565 CDD:293787 18/32 (56%)
HEAT repeat 867..894 CDD:293787 16/26 (62%)
HEAT repeat 906..936 CDD:293787 14/29 (48%)
HEAT repeat 947..979 CDD:293787 13/31 (42%)
RANBP6NP_036548.1 HEAT 1 219..257 13/38 (34%)
KAP95 <309..>640 CDD:227540 192/330 (58%)
HEAT repeat 330..353 CDD:293787 10/22 (45%)
Ran-GTP binding. /evidence=ECO:0000250 333..383 27/49 (55%)
HEAT 2 361..399 21/37 (57%)
HEAT repeat 363..395 CDD:293787 16/31 (52%)
HEAT 3 402..440 25/37 (68%)
HEAT repeat 407..437 CDD:293787 18/29 (62%)
HEAT 4 444..483 20/38 (53%)
HEAT repeat 449..476 CDD:293787 12/26 (46%)
HEAT repeat 502..526 CDD:293787 13/23 (57%)
HEAT repeat 539..572 CDD:293787 18/32 (56%)
HEAT 5 866..905 24/38 (63%)
HEAT repeat 873..898 CDD:293787 14/24 (58%)
HEAT 6 908..946 17/37 (46%)
HEAT repeat 910..942 CDD:293787 15/31 (48%)
HEAT 7 949..987 14/37 (38%)
HEAT repeat 954..990 CDD:293787 16/35 (46%)
HEAT repeat 999..1023 CDD:293787 11/23 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141346
Domainoid 1 1.000 410 1.000 Domainoid score I688
eggNOG 1 0.900 - - E1_KOG2171
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1178 1.000 Inparanoid score I196
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53802
OrthoDB 1 1.010 - - D56573at33208
OrthoFinder 1 1.000 - - FOG0003156
OrthoInspector 1 1.000 - - otm42022
orthoMCL 1 0.900 - - OOG6_101397
Panther 1 1.100 - - O PTHR10527
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2119
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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