Protein Alignment Karybeta3 and sal3

DIOPT Version :10

• Sequence 1: NP_524226.1
• Gene: Karybeta3 / 40581
• FlyBaseID: FBgn0087013
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_588502.1
• Gene: sal3 / 2539387
• PomBaseID: SPCC1840.03
• Length: 1095
• Species: Schizosaccharomyces pombe
• Alignment Length: 1127
• Identity: 394/1127 - (34%)
• Similarity: 616/1127 - (54%)
• Gaps: 96/1127 - (8%)

  Fly    11 LLASLLSTDNDVRQQAEEAYNN--LSRELKVTHLLGNIQNG-----QQSEE--ARQMAAVLLRRL 66
            |:..|.|.||.||..||::.::  :|:...:      :.||     .|||:  .|....||.||:
pombe    16 LVQGLSSPDNTVRNDAEKSLSSDWISQRADL------LLNGLAILAYQSEDPAVRSFCLVLCRRI 74

  Fly    67 -FTT----EFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQW 126
             |.|    ...:.:..:..||:..|..|:|....:|..|.:|.|:|:.:||:||::.  ||..:|
pombe    75 SFRTLPGDSELEVFSSISNESKQSLQSQLLACFVKESVPTVRNKLCDTIAEIARSIY--DCQGEW 137

  Fly   127 PDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQ-- 189
            |:::..:|...|||....:||..|..:|:|.:...|::....|....||       ||.:||:
pombe   138 PELINVIFNAVNSPDESFRESVFRTITSLPRLLSGQDSAVTPLFTTGLA-------DPSIRVRIS 195

  Fly   190 AVRAVGAFILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSL---LKLLIEMTENCPKFL 251
            |.||..|.||    |::.:.......:||.:::|.....:.:|..:|   |..:.|:.|..||..
pombe   196 AARAYSAVIL----ESKQSTRDQVIPLLPSLMNILPPLQQDRDSDNLADCLMAITEIAEVFPKLF 256

  Fly   252 RPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVALIPLILHMMTDL 316
            :|..|.:....:.:...::.::|.|...||::|..:|.||:|.||.:| |...|:...|.:|||:
pombe   257 KPIFESVIAFGLGIIKDKELDNSARQAALELLVCFSEGAPAMCRKSSD-YTDQLVLQCLLLMTDV 320

  Fly   317 DDD--------ENWSTADVVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADW 373
            ..|        :.|...|.:|.|:...|:|:||.::|||:..||||.:||.....||.::....|
pombe   321 AGDPEDEAEELQEWLNTDDLDQDESDANHVVAEQAMDRLSRKLGGKTILPPSFTWLPRLIPSQKW 385

  Fly   374 KHRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKK 438
            ..|.|||||||:|.||..|.|:..|..|:..||..|:|||||||:|||||:||||||||...:.|
pombe   386 SERHAALMAISSIAEGAEKLMKKELSRVLDMVLPLLADPHPRVRWAACNAVGQMSTDFAPDMQVK 450

  Fly   439 FHSQVIPGLLSLLDDVENPRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVE 503
            :.|:::..|:.:|:..|: ||||||.||:|||||:....:|..|||.|:.:|.|:|.|.
pombe   451 YPSRILEALVPVLESPES-RVQAHAAAAMVNFSEEADNKVLEPYLDDILQRLLTLLQSP------ 508

  Fly   504 KGNKLVLEQVVTTIASVADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLA 568
              .:.|.||.|||||:|||....:|..|:|.:||.|..::|.|:..:.|.|||||:||.:||.||
pombe   509 --KRYVQEQAVTTIATVADAAAKKFEKYFDAIMPLLFNVLQQADGKEFRTLRGKTMECATLIALA 571

  Fly   569 VGREKFIGDAGEVMDMLLVNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMR 633
            ||:::|:..:.|::.:|  .:.:.|....||||.||||:||.|:|::||..|..:|..||.|::.
pombe   572 VGKQRFLPVSQELIQIL--GNIQMGITDSDDPQASYLISAWGRICRVLGSDFVPFLSSVMPPLLV 634

  Fly   634 TATMKPEVAMLDNDEVEDI-----DGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYAREL 693
            .||.||:..::| |||::.     ||   |.||.:..|| ..|||:.::||.:|.|||||||.||
pombe   635 AATSKPDFTIID-DEVDESKYSEQDG---WEFIPVHGQQ-VGIRTSTLEDKCTATEMLVCYAAEL 694

  Fly   694 KEGFAEYAEDVVRQ-MLPMLKFYFHDGVRTAAAESLPYLLDC---AKIKGPQYLEGMWMFICPEL 754
            |..|..|..:|:.. :||.|||:||||||:|..:.:|.||:.   |..:.|..:..:|..|..:|
pombe   695 KADFDPYVNEVLTSVVLPGLKFFFHDGVRSACCKCIPQLLNARILASNRDPAKVNELWEPILRKL 759

  Fly   755 LKVIVTEPEPDVQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEE 819
            |..|..||..::.::......:.:|..|.| |:..:|:.::..::..:.....|..:|.......
pombe   760 LDHIQNEPSVEMLADYFECFYQSLEISGLN-LSPSSMEALVAAVDLQLKGFISRVQQREEEAKNG 823

  Fly   820 DYDDGVEEELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQW 884
            |.|...:|::....:.|..:|::|......:.:.:|..|.|.:|::.|:....|..:..|| :||
pombe   824 DIDIEEDEDMILAVENDQNLLNEINKTFSVVLKIHKTAFCPFWERLLPYMDGFLSGNDTVA-KQW 887

  Fly   885 GLCVFDDLIEFCGPACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQII 949
            .||:.||||||.||....|:..|.|.|.:.:....||:||||:||.||..|..||.:|..|:..:
pombe   888 ALCMMDDLIEFTGPDSWNYKDHFLPYLAEGIQSSEPEIRQAASYGIGVAAQHGGELYAEICSSAL 952

  Fly   950 PLLVQVINDPKAREIENISPTENAISAFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHI 1014
            |.|.:::..|.||:.|.|..|||...|..||.::.:..:.::|:::..|.:.|||:.|.::|.:.
pombe   953 PALFKMLELPDARDEEQIYATENICVAICKICRFCSQRVQDLDKVVTYWINTLPVTHDEDDAPYA 1017

  Fly  1015 YGYLCDLIEGNHPVILGANNGNLPRIVSIIAESFCTKVVEAQSATGTRMLTIVK---------QV 1070
            |.:|.:|:|.||..:.    ..:|.|::|:||:|.:.|:..:  |.||::...|         ||
pombe  1018 YTFLAELMEQNHVAVA----SQMPTIITILAETFASGVLRGR--TLTRLMEASKVYLARFPADQV 1076

  Fly  1071 ESNPEVMAACASTLSPEQQQAL 1092
            .|   |:|    |||.:.|:||
pombe  1077 NS---VIA----TLSVDNQRAL 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Karybeta3	NP_524226.1	KAP95	6..>625	CDD:227540	232/640 (36%)
		HEAT repeat	129..157	CDD:293787	8/27 (30%)
		HEAT repeat	165..216	CDD:293787	14/52 (27%)
		HEAT repeat	235..261	CDD:293787	8/28 (29%)
		Importin_rep_4	268..358	CDD:408579	34/97 (35%)
		HEAT repeat	272..305	CDD:293787	13/32 (41%)
		HEAT repeat	357..385	CDD:293787	12/27 (44%)
		HEAT repeat	401..429	CDD:293787	19/27 (70%)
		HEAT repeat	442..473	CDD:293787	15/30 (50%)
		HEAT repeat	485..519	CDD:293787	12/33 (36%)
		HEAT repeat	532..565	CDD:293787	14/32 (44%)
		Importin_rep_6	766..875	CDD:465881	19/108 (18%)
		HEAT repeat	867..894	CDD:293787	11/26 (42%)
		HEAT repeat	906..936	CDD:293787	13/29 (45%)
		HEAT repeat	947..979	CDD:293787	11/31 (35%)
		Importin_rep_5	1007..1059	CDD:465877	15/51 (29%)
sal3	NP_588502.1	KAP95	22..>502	CDD:227540	174/500 (35%)
		Importin_rep_4	273..370	CDD:408579	34/97 (35%)
		HEAT repeat	376..397	CDD:293787	10/20 (50%)
		HEAT_EZ	385..439	CDD:463906	32/53 (60%)
		HEAT	388..>528	CDD:441023	76/148 (51%)
		HEAT repeat	413..441	CDD:293787	19/27 (70%)
		HEAT repeat	451..484	CDD:293787	16/33 (48%)
		KAP95	<490..640	CDD:227540	67/159 (42%)
		HEAT repeat	496..522	CDD:293787	12/33 (36%)
		Importin_rep_6	771..878	CDD:465881	18/107 (17%)
		Importin_rep_5	1010..1061	CDD:465877	18/56 (32%)