Protein Alignment rpk and ASIC3

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 101/485 - (20%)
• Similarity: 169/485 - (34%)
• Gaps: 149/485 - (30%)

  Fly   132 LYSQFSEDMRASRVFRPENVSALEMEEFRTLLH----VCN------TQIIEEDI-----PLIAGD 181
            || |.:|.:|..|.|..:  :||:..|...|:.    :||      :::...|:     .|:..|
Human    57 LY-QVAERVRYYREFHHQ--TALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD 118

  Fly   182 DLDYFDVLQRM-----------LPQFDRYFFY-------------CRWLSRFGEC-ETFFRKTLT 221
            ..::...|:.:           .|.||....|             ||:  |...| ...|....|
Human   119 PAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRF--RGQPCGPENFTTIFT 181

  Fly   222 EEGICYTFN-GLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLS 285
            ..|.||||| |....|:.                          |...|
Human   182 RMGKCYTFNSGADGAELL--------------------------TTTRG---------------- 204

  Fly   286 AGARSGIFLALQSFKQEVDYACRGPV------QGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGK 344
             |..:|:.:.|.  .|:.:|.   ||      ..|:||  ..|.:|:.::.|.:.:..:.:..|.
Human   205 -GMGNGLDIMLD--VQQEEYL---PVWRDNEETPFEVG--IRVQIHSQEEPPIIDQLGLGVSPGY 261

  Fly   345 EVLIAVKPNMITM----------SSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFT 399
            :..::.:...::.          :|....|.|.......|...|..  ..||...|:|.|...:.
Human   262 QTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPS--PPYTLMGCRLACETRYV 324

  Fly   400 LTKCGCVKFSMPRNVDMPVCGEDKI-HCYDRAERELLVREFKRVKALNAGRENSRSVESACNCMP 463
            ..||||....||.  |:|||...:. :|...|...:|.::                   :|.|..
Human   325 ARKCGCRMVYMPG--DVPVCSPQQYKNCAHPAIDAMLRKD-------------------SCACPN 368

  Fly   464 ACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFITSKRSE 521
            .|.|..|..|:|...      :.:.....||       :.|....:..|.|:|:...:.|.::.:
Human   369 PCASTRYAKELSMVR------IPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKK 427

  Fly   522 LYGMTEFLANCGGIFGLFMGFSILSLVEMI 551
            .|.|:|.|.:.||..|||:|.|:|:::|::
Human   428 AYEMSELLGDIGGQMGLFIGASLLTILEIL 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	101/485 (21%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	101/485 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		5/21 (24%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)