Protein Alignment rpk and SCNN1D

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 58/299 - (19%)
• Similarity: 102/299 - (34%)
• Gaps: 106/299 - (35%)

  Fly   152 SRAILETHYFPDEDLIAHLNPLQRMSHS---------LHK-IREKQSW--------------SP- 191
            ||::|||.|    .|:.:|..|...:|:         ||: :.::::|              ||
Human  3255 SRSVLETRY----TLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPV 3315

  Fly   192 ---------EFFEHVKFYKMFQWWEVQMRDTATWLMHSDEFRRLPSHEKIAIFKIVWAVWRRFER 247
                     .:|...::|..::  .|.:..|..|.........:..|.:....    ..|:....
Human  3316 LEPNARKVEAYFPRARWYDYYK--GVDINATGEWKTLEAPLEYINLHIRGGYI----LPWQEPAM 3374

  Fly   248 YT-MSAQMF--------------GQKCYDEKIHVHNHQ-FAARFGNYHIDYSNVSDHGFERFNNV 296
            .| :|.|.|              |...:|:...::..| :.|||.   ::.:.:..|  |:|||.
Human  3375 NTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRINTDQYYLARFS---VNQTTLLTH--EKFNNY 3434

  Fly   297 FGGKMIRYFDIIVKPYLEL-NLSETEVTYILCQIVWNYAGRRLQGQTQAAGERFLEEISNNLHSY 360
            ..|....|..     |::: .||.:.:|.:  .|.||                     :||
Human  3435 LTGTAPLYLG-----YIDIWGLSSSSITNV--SISWN---------------------TNN---- 3467

  Fly   361 YEEAARKEENPKNYASRLTKMMQIVNEMLSIQLKRENTM 399
                   ||...||.| .||::.:......|.|...|::
Human  3468 -------EEVFANYNS-TTKILSVNMTDKKISLHTFNSL 3498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	58/299 (19%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777