Protein Alignment rpk and SCNN1B

DIOPT Version :9

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 144/636 - (22%)
• Similarity: 212/636 - (33%)
• Gaps: 199/636 - (31%)

  Fly    35 TYHE----YCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGC---STLIQSAYTKWTETPVI 92
            ||.|    ||.||:.||.:.: ..|.|.::.:::|...|.:...|   ...|:: |..| |..|.
Human    40 TYKELLVWYCDNTNTHGPKRI-ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRT-YLSW-EVSVS 101

  Fly    93 VSFAEKSTPVWNIPFPAVTVC-------SETKRVLKQKGKETTYADLYSQFSEDMRA--SRVFRP 148
            :|...|:     :.|||||:|       |:.|.:||         ||    .|.|.|  .|:..|
Human   102 LSVGFKT-----MDFPAVTICNASPFKYSKIKHLLK---------DL----DELMEAVLERILAP 148

  Fly   149 ENVSALEMEEFRTLLHVCNTQIIEEDI----PLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRF 209
            |            |.|...|:.:...|    ||:..|               :|...:...|..|
Human   149 E------------LSHANATRNLNFSIWNHTPLVLID---------------ERNPHHPMVLDLF 186

  Fly   210 GECETFFRKTLTEEGIC------------------YTFNG-------------LRATEIY----R 239
            |:.......:...|.||                  .||..             |:||.|:    :
Human   187 GDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQ 251

  Fly   240 DDTYQYQHSG-----------EPLEMENISS---QHTA------WTLETGYALDSDVETFPARVL 284
            .:..:..:.|           ||....|.:|   .|..      |.: |..||.|         .
Human   252 QELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGM-TEKALPS---------A 306

  Fly   285 SAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIA 349
            :.|...|:.|.| ...|| ||.   |......|  ..::||.....|.:..:.:....|.|..|.
Human   307 NPGTEFGLKLIL-DIGQE-DYV---PFLASTAG--VRLMLHEQRSYPFIRDEGIYAMSGTETSIG 364

  Fly   350 VKPNMITMSSGIAE-YHP-------VRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGC- 405
            |   ::.....:.| |.|       |..|.|.|.     :...|:...|...|..:..:..|.|
Human   365 V---LVDKLQRMGEPYSPCTVNGSEVPVQNFYSD-----YNTTYSIQACLRSCFQDHMIRNCNCG 421

  Fly   406 -VKFSMPR------NVDMPVCGEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESAC--NC 461
             ..:.:||      |.|.|    |..|||...:..:..||                   .|  .|
Human   422 HYLYPLPRGEKYCNNRDFP----DWAHCYSDLQMSVAQRE-------------------TCIGMC 463

  Fly   462 MPACTSLVYNTEISQANFDLE-------EMLVAEGDTEFLKEYPGSQMSRLSIYFKQSQFITSKR 519
            ..:|....|...||.|::..|       .:|..|.|...........:.:|:|||::..:.|.:.
Human   464 KESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEE 528

  Fly   520 SELYGMTEFLANCGGIFGLFMGFSILSLV---EMIYHFTLRLFTNLKRLVK 567
            |....:...|:|.||.||.:||.|:|.|:   |:|..|.......|..|.|
Human   529 SAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	136/611 (22%)
SCNN1B	XP_016879014.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720